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Sökning: WFRF:(Gavhed D)

  • Resultat 1-10 av 44
  • [1]2345Nästa
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2.
  • Lourda, M., et al. (författare)
  • Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients
  • 2014
  • Ingår i: Clinical Immunology. - 1521-6616 .- 1521-7035. ; 153:1, s. 112-122
  • Tidskriftsartikel (refereegranskat)abstract
    • Langerhans cell histiocytosis (LCH) is a rare disease of unknown cause with manifestations ranging from isolated granulomatous lesions to life-threatening multi-system organ involvement. This disorder is further characterized by infiltration of immune cells in affected tissues and an association with interleukin (IL)-17A has been reported. Here, we investigated the presence of IL-17A-producing cells among peripheral blood mononuclear cells isolated from LCH patients and observed a high percentage of IL-17A(+) monocytes in peripheral blood of LCH patients compared to controls. The IL-17A(+) monocytes were also positive for the transcription factor retinoic acid orphan receptor (ROR) gamma t and showed increased mRNA levels for both IL-17A and ROR gamma t. Notably, IL-17A was produced by all monocyte subsets and the expression level was positively associated with LCH disease activity. These data support a role for monocytes in the pathogenesis of LCH. Future therapeutic approaches may consider identification of patients who may benefit from IL-17A-targeted interventions. (C) 2014 Elsevier Inc. All rights reserved.
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3.
  • Akefeldt, Selma O, et al. (författare)
  • Langerhans cell histiocytosis in children born 1982-2005 after in vitro fertilization
  • 2012
  • Ingår i: Acta Paediatrica. - : Wiley-Blackwell. - 0803-5253 .- 1651-2227. ; 101:11, s. 1151-1155
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: In a recent Swedish study, comparing data from the Swedish Cancer Register with the Medical Birth Register including data on IVF, an increased risk of Langerhans cell histiocytosis (LCH) was found in children born 19822005 after IVF. Here, we aimed to verify the LCH diagnoses and examine whether any special forms of the disease were overrepresented in this population. Methods: Medical records for all children with LCH conceived by IVF were acquired and the diagnosis confirmed or discarded. Disease characteristics were compared with data from children diagnosed with LCH 19922001 in the Stockholm County. Results: We verified LCH in seven children born after IVF, all born prior to 2002. These children did not have milder disease forms. The odds ratio (OR) to develop LCH for the whole group born after IVF was 3.2 [95% confidence interval (CI), 1.47.3] and for children born before 2002, 5.2 [95% CI, 2.311.9], compared with children in Stockholm County 19922001. Conclusion: LCH was overrepresented in children born after IVF prior to 2002. Affected children did not have milder disease forms. These findings may be valuable to understand LCH aetiology. Additional studies on a putative correlation between IVF and LCH in the offspring are encouraged.
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  • Gavhed, Desiree, et al. (författare)
  • Biomarkers in the Cerebrospinal Fluid and Neurodegeneration in Langerhans Cell Histiocytosis
  • 2009
  • Ingår i: Pediatric Blood & Cancer. - : John Wiley and Sons. - 1545-5017. ; 53:7, s. 1264-1270
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Progressive neurodegeneration may result in potentially severe cognitive and motor dysfunctions as a complication of Langerhans cell histiocytosis (LCH), a suggested IL-17A-associated inflammatory condition. To detect this complication (CNS-LCH) early and to evaluate the potential efficacy of therapeutic interventions, biomarkers detecting and measuring ongoing neurodegeneration Would be valuable. We evaluated cerebrospinal fluid (CSF) biomarkers of ongoing neurodegeneration in CNS-LCH patients. Procedure. Nine patients with endocrine, neuromotor, cognitive or/and behavioral abnormalities as well as neuroradiological evidence of CNS-LCH were evaluated 4-12 years after LCH diagnosis for CSF levels of neurofilament protein light chain (NF-L), glial fibrillary acid protein (GFAp), and total tau protein (TAU). Two patients were analyzed longitudinally. One hundred ten children with newly diagnosed acute lymphoblastic leukemia (ALL) served as controls. Results. NF-L, TAU, and GFAp levels were elevated in four, six, and eight of nine patients studied, respectively. NF-L (P < 0.001) and GFAp (P < 0.001) were higher in patients than in controls (TAU not analyzed in controls). The patient with most severe clinical and neuroradiological CNS-LCH displayed the highest levels of NF-L and GFAp whereas three patients without signs of systemic disease had low TAU levels and normal/slightly elevated NF-L. NF-L tended to be higher at radiological progression of neurodegeneration than at Status quo (P = 0.07). Notably, we experienced frequent lumbar puncture complications in these patients. Conclusions. CSF levels of NF-L, TAU, and GFAp appear to be elevated in CNS-LCH. It would be valuable if these markers were validated in order to serve as markers for early CNS-LCH, to monitor disease progression and to evaluate various treatment attempts for CNS-LCH. Pediatr Blood Cancer 2009;53:1264-1270. (C) 2009 Wiley-Liss, Inc.
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6.
  • Giedraityte, Lina, et al. (författare)
  • Validation of methods for determination of metabolic rate in the Edholm scale and ISO 8996
  • 2001
  • Ingår i: International Journal of Occupational Safety and Ergonomics. - 1080-3548 .- 2376-9130. ; 7:2, s. 135-48
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to validate the Edholm scale (Edholm, 1966) and the ISO 8996 standard (International Organization for Standardization [ISO], 1990) by comparing the metabolic rates estimated for both methods with the actual measured metabolic rate (MMeas) in 6 manual material handling tasks simulated under laboratory conditions. The metabolic rate was calculated from oxygen consumption VO2 (19 participants) according to Standard No. ISO 8996 (ISO, 1990). Additionally, the participants estimated perceived exertion using the Borg scale. The metabolic rates derived from the Edholm scale (MEdh) overestimated 5 of 6 activities by 34-50% (alpha = .05). The metabolic rates derived from ISO 8996 (MISO) overestimated all activities by 7-38% (alpha = .05).
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  • Holmér, Ingvar, et al. (författare)
  • Classification of metabolic and respiratory demands in fire fighting activity with extreme workloads
  • 2007
  • Ingår i: Applied Ergonomics. - : Elsevier. - 1872-9126 .- 0003-6870. ; 38:1, s. 45-52
  • Tidskriftsartikel (refereegranskat)abstract
    • Fire fighting work comprises work tasks requiring an energy yield at maximal or close to maximal levels of the individual. Due to the very nature of fire fighting more complex physiological variables are difficult to measure. We measured metabolic and respiratory responses in 15 male.. professional fire fighters during simulated work tasks on a test ground. Work time was on the average 22 min with individual components of work tasks lasting 2-4 min. The mean oxygen consumption for the whole exercise (22 min) was 2.75 +/- 0.291/min. The most demanding work task demanded an oxygen uptake of 3.55 +/- 0.271/min. Corresponding values for respiratory minute volumes were 82 +/- 14 and 102 +/- 141/min, respectively. Heart rates averaged 168 +/- 12 for the whole test and 179 +/- 13 beats/min for the heaviest work task. Two new classes for classification of intensive and exhausting, short term physical work are proposed for inclusion in ISO8996 and values for relevant parameters are proposed. (c) 2006 Elsevier Ltd. All rights reserved.
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9.
  • Kuklane, Kalev, et al. (författare)
  • A field study in dairy farms : thermal condition of feet
  • 2001
  • Ingår i: International Journal of Industrial Ergonomics. - 0169-8141 .- 1872-8219. ; 27:1, s. 367-373
  • Tidskriftsartikel (refereegranskat)abstract
    • The study aimed to find out the problems connected with feet during work in cold loose housing barns in wintertime. Thirteen dairy farms and 20 workers were studied. Skin temperatures and subjective responses were collected, and at the end of a work period the subjects filled in a questionnaire about the workday. The foot skin temperatures were measured on dorsal foot and second toe. Most of the workers used rubber boots. The ambient temperature outdoors varied from +5 to -11°C. Indoor temperatures could be the same as outdoors (cold barns and fodder storage) but also close to +30°C (milk room). The lowest mean foot and toe skin temperatures were 24.1±2.6°C and 16.0±1.4°C. The lowest measured values were 20.1°C and 12.8°C, respectively. The toe temperatures were on average 7.3°C colder than foot temperatures (mean 28.8°C). The low foot skin temperature was well related to cold sensation. Low toe temperatures fitted well with wetness sensation. On average the thermal sensation of feet over the work period was neutral. The lowest ratings were cold (-2). The combination of various environmental factors in farms complicates finding of perfect footwear for work. Recommendations on the choice of footwear and their care are given.
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  • Resultat 1-10 av 44
  • [1]2345Nästa

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