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Träfflista för sökning "WFRF:(Geha RS) "

Sökning: WFRF:(Geha RS)

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  • Gerasimcik, Natalija, et al. (författare)
  • The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells
  • 2015
  • Ingår i: Journal of Immunology. - 0022-1767 .- 1550-6606. ; 194:10, s. 4750-4758
  • Tidskriftsartikel (refereegranskat)abstract
    • The Rho GTPase Cdc42 coordinates regulation of the actin and the microtubule cytoskeleton by binding and activating the Wiskott-Aldrich syndrome protein. We sought to define the role of intrinsic expression of Cdc42 by mature B cells in their activation and function. Mice with inducible deletion of Cdc42 in mature B cells formed smaller germinal centers and had a reduced Ab response, mostly of low affinity to T cell-dependent Ag, compared with wild-type (WT) controls. Spreading formation of long protrusions that contain F-actin, microtubules, and Cdc42-interacting protein 4, and assumption of a dendritic cell morphology in response to anti-CD40 plus IL-4 were impaired in Cdc42-deficient B cells compared with WT B cells. Cdc42-deficient B cells had an intact migratory response to chemokine in vitro, but their homing to the B cell follicles in the spleen in vivo was significantly impaired. Cdc42-deficient B cells induced a skewed cytokine response in CD4(+) T cells, compared with WT B cells. Our results demonstrate a critical role for Cdc42 in the motility of mature B cells, their cognate interaction with T cells, and their differentiation into Ab-producing cells.
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  • Brodeur, SR, et al. (författare)
  • C4b-binding protein (C4BP) activates B cells through the CD40 receptor
  • 2003
  • Ingår i: Immunity. - : Cell Press. - 1074-7613. ; 18:6, s. 837-848
  • Tidskriftsartikel (refereegranskat)abstract
    • We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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