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- Brodeur, SR, et al.
(författare)
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C4b-binding protein (C4BP) activates B cells through the CD40 receptor
- 2003
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Ingår i: Immunity. - 1074-7613. ; 18:6, s. 837-848
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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