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Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

Merino, Jordi (author)
Broad Institute,Massachusetts General Hospital
Dashti, Hassan S. (author)
Broad Institute,Massachusetts General Hospital
Li, Sherly X. (author)
University of Cambridge
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Sarnowski, Chloé (author)
Boston University
Justice, Anne E. (author)
Sigfried and Janet Weis Center for Research,University of North Carolina
Graff, Misa (author)
University of North Carolina
Papoutsakis, Constantina (author)
Smith, Caren E. (author)
Dedoussis, George V. (author)
Harokopio University
Lemaitre, Rozenn N. (author)
University of Washington
Wojczynski, Mary K. (author)
Washington University in St. Louis
Männistö, Satu (author)
Finnish National Institute for Health and Welfare
Ngwa, Julius S. (author)
Boston University,Johns Hopkins Bloomberg School of Public Health
Kho, Minjung (author)
University of Michigan
Ahluwalia, Tarunveer S. (author)
University of Copenhagen
Pervjakova, Natalia (author)
University of Tartu,Finnish National Institute for Health and Welfare,Imperial College London
Houston, Denise K. (author)
Wake Forest University
Bouchard, Claude (author)
Pennington Biomedical Research Center
Huang, Tao (author)
Peking University
Orho-Melander, Marju (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
Frazier-Wood, Alexis C. (author)
Mook-Kanamori, Dennis O. (author)
Leiden University Medical Centre
Pérusse, Louis (author)
Institute of Nutrition and Functional Foods, Canada,Laval University
Pennell, Craig E. (author)
de Vries, Paul S. (author)
University of Texas
Voortman, Trudy (author)
Erasmus University Medical Center
Li, Olivia (author)
Kanoni, Stavroula (author)
Queen Mary University
Rose, Lynda M. (author)
Brigham and Women's Hospital / Harvard Medical School
Lehtimäki, Terho (author)
University of Tampere
Zhao, Jing Hua (author)
University of Cambridge
Feitosa, Mary F. (author)
Washington University in St. Louis
Luan, Jian’an (author)
University of Cambridge
McKeown, Nicola M. (author)
Smith, Jennifer A. (author)
University of Michigan
Hansen, Torben (author)
University of Copenhagen
Eklund, Niina (author)
Finnish National Institute for Health and Welfare
Nalls, Mike A. (author)
Data Tecnica International,National Institute on Aging, United States
Rankinen, Tuomo (author)
Pennington Biomedical Research Center
Huang, Jinyan (author)
Hernandez, Dena G. (author)
National Institute on Aging, United States
Schulz, Christina Alexandra (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
Manichaikul, Ani (author)
University of Virginia
Li-Gao, Ruifang (author)
Leiden University Medical Centre
Vohl, Marie Claude (author)
Institute of Nutrition and Functional Foods, Canada,Laval University
Wang, Carol A. (author)
van Rooij, Frank J.A. (author)
Erasmus University Medical Center
Shin, Jean (author)
Hospital for Sick Children, Toronto
Ericson, Ulrika (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
Perola, Markus (author)
Finnish National Institute for Health and Welfare
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 (creator_code:org_t)
2018-07-09
2019
English 13 s.
In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 24:12, s. 1920-1932
Related links:
http://dx.doi.org/10...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the genetic landscape of macronutrient intake, identifying 12 suggestively significant loci (P < 1 × 10−6) associated with intake of any macronutrient in 91,114 European ancestry participants. Four loci replicated and reached genome-wide significance in a combined meta-analysis including 123,659 European descent participants, unraveling two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings. In additional analysis of 144,770 participants from the UK Biobank, all identified associations from the two-stage analysis were confirmed except for DRAM1. Identified loci might have implications in brain and adipose tissue biology and have clinical impact in obesity-related phenotypes. Our findings provide new insight into biological functions related to macronutrient intake.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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