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- Berglund, Kristina, 1969, et al.
(författare)
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Childhood Maltreatment Affects the Serotonergic System in Male Alcohol-Dependent Individuals
- 2013
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Ingår i: Alcoholism. - : Wiley. - 0145-6008 .- 1530-0277. ; 37:5, s. 757-762
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Tidskriftsartikel (refereegranskat)abstract
- Background: Reduced central serotonergic neurotransmission has been demonstrated in individuals with excessive alcohol consumption and/or alcohol dependence. Childhood maltreatment has also been found to have a negative impact on central serotonergic neurotransmission. The aim of this study was to evaluate the impact of childhood maltreatment on central serotonergic dysfunction in alcohol-dependent individuals.Methods: Adult men with a diagnosis of alcohol dependence (n=18) were recruited from outpatient treatment units for alcoholism. Central serotonergic neurotransmission was assessed by a neuroendocrine method, that is, the prolactin (PRL) response to the selective 5-HT reuptake inhibitor citalopram. Childhood maltreatment was assessed retrospectively by the Childhood Trauma Questionnaire.Results: Alcohol-dependent individuals with childhood experience of emotional abuse had significantly lower PRL response compared with those without such abuse (3 +/- 5 and 64 +/- 24mU/l, respectively; t=6.51, p<0.001). Among those who reported childhood emotional abuse, 4 of 7 individuals had flat PRL responses in comparison with none in those with no report of such abuse (p<0.01).Conclusions: This is the first study to show that self-reported childhood maltreatment, in particular emotional abuse, in male alcohol-dependent individuals is associated with a quite dramatic (more than 90%) reduction in central serotonergic neurotransmission. It should, however, be noted that the number of individuals is relatively small, and the results should therefore be considered as preliminary.
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| 4. |
- Abrahamsson, Agneta, et al.
(författare)
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Sense of coherence of reindeer herders and other Samis in comparison to other Swedish citizens
- 2013
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Ingår i: International Journal of Circumpolar Health. - : Informa UK Limited. - 1239-9736 .- 2242-3982. ; 72:1, s. Art. no. 20633-
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Tidskriftsartikel (refereegranskat)abstract
- Background. Samis are indigenous people in north Europe. In the territory called Sapmi (Lapland), reindeer herding is the traditional base for the Sami economy. The relation between living conditions and positive health of the Swedish Samis has been sparsely studied. As health is closely linked to sense of coherence (SOC), an understanding of the background factors to SOC may contribute knowledge that might be useful in promoting living conditions and health. Methods. The study examines relations between the level of SOC and background factors from surveys in a Sami population (n = 613) in comparison to a non-Sami population (n = 525) in Sweden, and in comparison between 2 subsamples of Samis, that is, herders and non-herders. Results. There are more similarities than differences between the Sami and non-Sami populations. However, dividing the Sami population, reindeer herders had significantly lower SOC, and in specific the subcomponent manageability, that is, less ability to use available resources to meet different demands in life, compared to non-herders. Conclusions. In addition to age and health, predictors of SOC are related to the life form of reindeer husbandry and the belonging to the herding community.
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| 5. |
- Gerdner, Arne, et al.
(författare)
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Alkoholism som sjukdom
- 1993
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Ingår i: Nordisk Alkoholtidskrift. - 0789-6069. ; 10:3, s. 133-144
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Tidskriftsartikel (refereegranskat)
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| 6. |
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| 7. |
- Gerdner, Arne
(författare)
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Diagnosinstrument för beroende och missbruk – Granskning av ADDIS validitet och interna konsistens gällande alkoholproblem
- 2009
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Ingår i: Nordic Studies on Alcohol and Drugs. - : Sage Publications. - 1455-0725 .- 1458-6126. ; 26:3, s. 265-276
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Tidskriftsartikel (refereegranskat)abstract
- The Swedish National Board on Health and Welfare recommends that structured assessment instruments should be used in medical as well as in social treatment of substance misusers. These should be validated in a Swedish context. Instruments for diagnoses of dependence/abuse (DSM-IV) and dependence/harmful use (ICD-10) have been used in Sweden for many years, although not yet validated in Swedish. ADDIS, Swedish version of the American SUDDS, is used in four Nordic countries and the most often used diagnostic instrument in Sweden. This article investigates the psychometric properties of ADDIS alcohol module, including discriminant and construct validity and internal consistency. The two main constructs in DSM – dependence and abuse – as well as the seven criteria for dependence and the four criteria for abuse are studied. Further, the value of each of the 44 specific items in ADDIS for capturing these criteria is studied.Two samples are explored: 1) a clinical sample (n = 349; incl. 129 women) and 2) a sample of 400 men convicted for driving while intoxicated. Mean age was the same (41 ys.). Using discriminant analyses on lifetime prevalence, the items correctly classify 94 % of the cases in the two samples. Using one-factor principal component analysis to explore homogeneity of the combined samples, all 28 items on dependence and 15 of 18 items on abuse have loadings above 0,40 (R2 dependence = 0,46; abuse = 0,40). Separate analyses of the two samples, as well as on women, show similar results. Cronbach’s alpha is excellent for dependence and satisfactory for abuse in all analyses. Analyses of specific criteria show satisfactory results on dependence and acceptable on abuse. Minor revisions are proposed to make ADDIS more user-friendly and to improve some specific items. In conclusion: ADDIS has acceptable to excellent discriminant and construct validity as well as internal consistency and captures the specific criteria of DSM-IV. It has the preconditions for sensitive assessment of alcohol use disorders in men and women.
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| 9. |
- Gerdner, Arne, et al.
(författare)
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Factors affecting motivation to treatment in severely dependent alcoholics
- 2000
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Ingår i: Journal of Studies on Alcohol. - 0096-882X .- 1934-2683. ; 61:4, s. 548-560
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The paper explores environmental, developmental and personality related factors as predictors of motivation to treatment for alcoholism using concepts such as social situation on admission, treatment career, age, education and adventurous patterns of behavior. Method: The original population consists of 603 severely dependent alcoholic patients (mean age 40 years, 24% women, 42% compulsorily committed). In a structural equation model estimation, 85% of the original cases were used, compulsorily as well as voluntarily admitted patients. A reduced model was tried on voluntary patients alone. Results: In the main model, pattern of behavior and age were not related to the motivation to treatment, while treatment career had some negative impact. Social problems were related to less motivation to treatment. In turn, a worse social situation was related to more treatment experience. The reduced model on voluntary patients alone confirmed the main findings, although more previous treatment tended to be related to more motivation. Conclusion: Motivation was mostly related to a better social situation, having �more to lose�. A collapse in the social situation was more an obstacle than a promoter of motivation. There was no support for statements that �maturing out� would result in more motivation and inconclusive findings concerning the impact on motivation from having many previous treatment experiences. The pattern of behavior was not directly related to the level of motivation. Based on these findings, the relevance of social work for motivation to treatment is discussed.
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