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Sökning: WFRF:(Geskin G)

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  • Moore, MR, et al. (författare)
  • Automated digital TIL analysis (ADTA) adds prognostic value to standard assessment of depth and ulceration in primary melanoma
  • 2021
  • Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 2809-
  • Tidskriftsartikel (refereegranskat)abstract
    • Accurate prognostic biomarkers in early-stage melanoma are urgently needed to stratify patients for clinical trials of adjuvant therapy. We applied a previously developed open source deep learning algorithm to detect tumor-infiltrating lymphocytes (TILs) in hematoxylin and eosin (H&E) images of early-stage melanomas. We tested whether automated digital (TIL) analysis (ADTA) improved accuracy of prediction of disease specific survival (DSS) based on current pathology standards. ADTA was applied to a training cohort (n = 80) and a cutoff value was defined based on a Receiver Operating Curve. ADTA was then applied to a validation cohort (n = 145) and the previously determined cutoff value was used to stratify high and low risk patients, as demonstrated by Kaplan–Meier analysis (p ≤ 0.001). Multivariable Cox proportional hazards analysis was performed using ADTA, depth, and ulceration as co-variables and showed that ADTA contributed to DSS prediction (HR: 4.18, CI 1.51–11.58, p = 0.006). ADTA provides an effective and attainable assessment of TILs and should be further evaluated in larger studies for inclusion in staging algorithms.
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3.
  • Vonau, F, et al. (författare)
  • Branched Substituents Generate Improved Supramolecular Ordering in Physisorbed Molecular Assemblies
  • 2009
  • Ingår i: JOURNAL OF PHYSICAL CHEMISTRY C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 113:12, s. 4955-4959
  • Tidskriftsartikel (refereegranskat)abstract
    • We present an experimental study supported by molecular simulations of the influence of the shape of alkyl side groups on the interactions and self-organization of supramolecular assemblies, built from bis-ureasubstituted toluene molecules deposited on Au(111) surfaces. In particular, we demonstrate the crucial importance of the presence of branched alkyl groups (i.e., ethylhexyl) that allow two adjacent supramolecular polymers to arrange closer to each other, leading to the formation of molecular "zippers". Thus, steric constraints at the level of individual molecules can generate improved Ordering between neighboring supramolecular polymers interacting with a planar substrate.
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