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Profiling of the plasma proteome across different stages of human heart failure
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- Egerstedt, Anna (author)
- Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Berntsson, John (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Smith, Maya Landenhed (author)
- Lund University,Lunds universitet,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Skåne University Hospital
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- Sinha, S (author)
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- (creator_code:org_t)
- 2019-12-20
- 2019
- English.
- In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 5830-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Egerstedt, Anna
- Berntsson, John
- Smith, Maya Land ...
- Gidlöf, Olof
- Nilsson, R
- Benson, M
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- Wells, QS
- Celik, Selvi
- Lejonberg, Carl
- Farrell, L
- Sinha, S
- Shen, DX
- Lundgren, Jakob
- Rådegran, Göran
- Ngo, D
- Engström, Gunnar
- Yang, Q
- Wang, TJ
- Gerszten, RE
- Smith, J. Gustav
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- Karolinska Institutet
- Lund University
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