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Melphalan and predn...
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
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- Waage, Anders (författare)
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway,NTNU
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- Gimsing, Peter (författare)
- Department of Hematology, Rigshospitalet and University of Copenhagen
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- Fayers, Peter (författare)
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
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- Abildgaard, Niels (författare)
- Department of Hematology, Odense University Hospital, Odense, Denmark
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- Ahlberg, Lucia (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US
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- Björkstrand, Bo (författare)
- Hematology Centre, Karolinska University Hospital/Huddinge, Stockholm, Sweden
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- Carlson, Kristina (författare)
- Uppsala universitet,Medicin,Hematologi,Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
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- Forsberg, Karin (författare)
- Umeå universitet,Onkologi,Norrland University Hospital
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- Dahl, Inger Marie (författare)
- Department of Medicine, University Hospital Tromsø, Tromsø, Norway
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- Gulbrandsen, Nina (författare)
- Department of Hematology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
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- Haukas, Einar (författare)
- Department of Medicine, Stavanger University Hospital, Stavanger, Norway
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- Hjertner, Öyvind (författare)
- Department of Hematology, St Olavs Hospital and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
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- Hjorth, Martin (författare)
- Department of Hematology, Lidköping Hospital, Lidköping, Sweden
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- Karlsson, Torbjörn (författare)
- Uppsala universitet,Medicin,Hematologi,Department of Internal Medicine, Capio Sankt Görans Hospital, Stockholm, Sweden
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- Knudsen, Lene Meldgaard (författare)
- Department of Hematology, Herlev Hospital, Copenhagen, Denmark
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- Nielsen, Johan Lanng (författare)
- Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
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- Linder, Olle (författare)
- Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Mellqvist, Ulf-Henrik (författare)
- Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Nesthus, Ingerid (författare)
- Department of Medicine, Haukeland University Hospital, Bergen, Norway
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- Rolke, Jurgen (författare)
- Department of Medicine, Kristiansand Hospital, Kristiansand, Norway
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- Strandberg, Maria (författare)
- Department of Medicine, Sundsvalls Hospital, Sundsvall, Sweden
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- Sörbo, Jon Hjalmar (författare)
- Department of Medicine, Levanger Hospital, Levanger, Norway
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- Wislöff, Finn (författare)
- Department of Hematology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
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- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Hospital, Lund, Sweden
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- Turesson, Ingemar (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Medicine, Malmö University Hospital, Malmö, Sweden
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(creator_code:org_t)
- American Society of Hematology, 2010
- 2010
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 116:9, s. 1405-1412
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- In this double-blind, placebo-controlled study, 363 patients with untreated multiple myeloma were randomized to receive either melphalan-prednisone and thalidomide (MPT) or melphalan-prednisone and placebo (MP). The dose of melphalan was 0.25 mg/kg and prednisone was 100 mg given daily for 4 days every 6 weeks until plateau phase. The dose of thalidomide/placebo was escalated to 400 mg daily until plateau phase and thereafter reduced to 200 mg daily until progression. A total of 357 patients were analyzed. Partial response was 34% and 33%, and very good partial response or better was 23% and 7% in the MPT and MP arms, respectively (P < .001). There was no significant difference in progression-free or overall survival, with median survival being 29 months in the MPT arm and 32 months in the MP arm. Most quality of life outcomes improved equally in both arms, apart from constipation, which was markedly increased in the MPT arm. Constipation, neuropathy, non-neuropathy neurologic toxicity, and skin reactions were significantly more frequent in the MPT arm. The number of thromboembolic events was equal in the 2 treatment arms. In conclusion, MPT had a significant antimyeloma effect, but this did not translate into improved survival. This trial was registered at www.clinicaltrials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
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Blood
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Waage, Anders
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Gimsing, Peter
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Fayers, Peter
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Abildgaard, Niel ...
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Ahlberg, Lucia
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Björkstrand, Bo
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Carlson, Kristin ...
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Forsberg, Karin
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Dahl, Inger Mari ...
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Gulbrandsen, Nin ...
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Haukas, Einar
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Hjertner, Öyvind
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Hjorth, Martin
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Karlsson, Torbjö ...
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Knudsen, Lene Me ...
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Nielsen, Johan L ...
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Linder, Olle
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Mellqvist, Ulf-H ...
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Nesthus, Ingerid
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Rolke, Jurgen
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Strandberg, Mari ...
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Sörbo, Jon Hjalm ...
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Wislöff, Finn
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Juliusson, Gunna ...
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Turesson, Ingema ...
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