↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Gocheva N) "

Search: WFRF:(Gocheva N)

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Bonaca, MP, et al. (author) Long-term use of ticagrelor in patients with prior myocardial infarction 2015 In: The New England journal of medicine. - 1533-4406. ; 372:19, s. 1791-1800 Journal article (peer-reviewed)
2.	Lau, Allison N., et al. (author) Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma 2020 In: eLife. - 2050-084X. ; 9, s. 1-35 Journal article (peer-reviewed)abstract Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time needed to isolate cells. To overcome this challenge, we traced isotope-labeled nutrients into macromolecules that turn over more slowly than metabolites. This approach was used to assess differences between cancer cell and fibroblast metabolism in murine pancreatic cancer organoid-fibroblast co-cultures and tumors. Pancreatic cancer cells exhibited increased pyruvate carboxylation relative to fibroblasts, and this flux depended on both pyruvate carboxylase and malic enzyme 1 activity. Consequently, expression of both enzymes in cancer cells was necessary for organoid and tumor growth, demonstrating that dissecting the metabolism of specific cell populations within heterogeneous systems can identify dependencies that may not be evident from studying isolated cells in culture or bulk tissue.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Chen, L (1); Berger, N. (1); Chen, Y. (1); Cole, B. (1); Garcia, C. (1); Hu, D. (1); show more...; Johansson, P. (1); Lee, H. (1); Li, S. (1); Li, Y. (1); Liu, Y. (1); Schmidt, E. (1); White, A. (1); Yamamoto, K. (1); Zhang, Z. (1); Zhu, J. (1); Zimmermann, S. (1); Berglund, E. (1); Okada, S. (1); Gupta, A. (1); Hill, D. (1); Sasaki, T. (1); Wright, D. (1); Nelson, S. (1); Omland, T. (1); Park, J (1); Taylor, D (1); Choi, S. (1); Johnson, M. (1); Schmidt, A. (1); Savage, C. (1); Bose, S. (1); Diaz, R. (1); Russo, G. (1); Yoon, J. (1); Da Silva, R. (1); Mazzoni, A. (1); Black, M (1); Aggarwal, R. (1); Costa, M. (1); Lee, A. (1); Medina, J (1); Zhou, H. (1); Griffin, S. (1); Dellborg, M (1); Gullestad, L (1); Hall, C (1); Alexander, J (1); Edwards, M. (1); Weiss, R. (1); show less...

University: Chalmers University of Technology (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view