| 1. |
- Bernal, Ximena E., et al.
(författare)
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Empowering Latina scientists
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 363:6429, s. 825-826
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Acharya, B. S., et al.
(författare)
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Introducing the CTA concept
- 2013
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Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
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| 3. |
- Agustin, Sanchez-Arcilla, et al.
(författare)
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Introduction
- 2008
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Ingår i: Journal of Hydraulic Research. - 0022-1686. ; 46:2, s. 179-182
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
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| 5. |
- Hefzi, Hooman, et al.
(författare)
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Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells
- 2024
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production via knockout have failed in mammalian bioprocessing since lactate dehydrogenase has proven essential. However, here we eliminated the Warburg effect in Chinese hamster ovary (CHO) and HEK293 cells by simultaneously knocking out lactate dehydrogenase and regulators involved in a negative feedback loop that typically inhibits pyruvate conversion to acetyl-CoA. In contrast to long-standing assumptions about the role of aerobic glycolysis, Warburg-null cells maintain wildtype growth rate while producing negligible lactate. Further characterization of Warburg-null CHO cells showed a compensatory increase in oxygen consumption, a near total reliance on oxidative metabolism, and higher cell densities in fed-batch cell culture. These cells remained amenable for production of diverse biotherapeutic proteins, reaching industrially relevant titers and maintaining product glycosylation. Thus, the ability to eliminate the Warburg effect is an important development for biotherapeutic production and provides a tool for investigating a near-universal metabolic phenomenon.
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| 6. |
- Huertas-Hernando, Daniel, et al.
(författare)
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Hydropower Flexibility for Power Systems with Variable Renewable Energy Sources: An IEA Task 25 Collaboration
- 2019
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Ingår i: Advances in Energy Systems. - : Wiley. ; , s. 385-405
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In order to effectively utilize hydro production flexibility, a sufficient amount of transmission capacity has to be available between the hydro-dominated part of the system and the part that requires operational flexibility. This chapter starts with a rough categorization of “base” hydropower flexibility, investigating the types of hydropower plants installed in power systems today. The “effective” hydropower flexibility available to support the integration of variable generation is a far more complex and case-specific aspect. It is discussed through national experiences. The chapter presents potential developments that would increase the participation of hydropower and discuss the ensuing challenges. Modeling a flow-based hydro system is a complex exercise, as is modeling the power system. Especially important is the correct assessment of hydropower flexibility to support power systems with a large share of variable generation (VG) and its value for storage. With increasing uncertainty and variability, a stochastic scheduling approach should yield lower costs.
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