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  • Kehoe, Laura, et al. (creator_code:aut_t)
  • Make EU trade with Brazil sustainable
  • 2019
  • record:In_t: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • swepub:Mat_article_t (swepub:level_scientificother_t)
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3.
  • Hudson, Thomas J., et al. (creator_code:aut_t)
  • International network of cancer genome projects
  • 2010
  • record:In_t: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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  • Lu, Dasheng, et al. (creator_code:aut_t)
  • Exploring Single-Nanoparticle Dynamics at High Temperature by Optical Tweezers
  • 2020
  • record:In_t: Nano letters (Print). - : American Chemical Society (ACS). - 1530-6984 .- 1530-6992. ; 20:11, s. 8024-8031
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • The experimental determination of the velocity of a colloidal nanoparticle (v(Np)) has recently became a hot topic. The thermal dependence of v(Np) is still left to be explored although it is a valuable source of information allowing, for instance, the discernment between ballistic and diffusive regimes. Optical tweezers (OTs) constitute a tool especially useful for the experimental determination of v m , although they have only been capable of determining it at room temperature. In this work, we demonstrate that it is possible to determine the temperature dependence of the diffusive velocity of a single colloidal nanoparticle by analyzing the temperature dependence of optical forces. The comparison between experimental results and theoretical predictions allowed us to discover the impact that the anomalous temperature dependence of water properties has on the dynamics of colloidal nanoparticles in this temperature range.
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  • Salas, Emir, et al. (creator_code:aut_t)
  • A heterogeneous enzymatic assay for quantification of Plasmepsin II activity and the evaluation of its inhibitors
  • 2004
  • record:In_t: Journal of Pharmaceutical and Biomedical Analysis. - 0731-7085 .- 1873-264X. ; 34:4, s. 833-840
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • The emergence and worldwide spreading of Plasmodium falciparum strains that shown to be resistant to traditional drugs is considered a very serious health problem, given the high mortality and morbidity rate of Malaria. In the search for new drugs against this parasite, Hb hydrolyzing enzymes, such as Plasmepsin II (Plm II), have been classified as very promising targets for therapeutic attacks. In this work, it is developed a cheap and high-throughput heterogeneous enzymatic assay for measuring Plasmepsin II activity in order to use it as a tool in the discovery of new inhibitors of this enzyme. In this assay, Plasmepsin II acts upon a solid-phase bound synthetic peptide (DU2) whose sequence comprises the cleavage site F(33)-L(34) present in Hb alpha-chain. The peptide surface density is quantified by means of a classical ELISA-based procedure. In order to estimate the kinetic constants of the system and to quantify both, enzymatic and inhibitory activity, it was used a model for the kinetics of enzyme quasi-saturable systems previously developed by our group, that fitted very well to the experimental data. It was used Pepstatin as a model inhibitor of Plasmepsin II and the resulting dose-response relation agreed with the expected behavior for the Pepstatin-Plasmepsin II pair under the employed experimental conditions.
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8.
  • Aparicio, Francisco J., et al. (creator_code:aut_t)
  • Transparent Nanometric Organic Luminescent Films as UV-Active Components in Photonic Structures
  • 2011
  • record:In_t: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 23:6, s. 761-765
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • A new kind of visible-blind organic thin-film material, consisting of a polymeric matrix with a high concentration of embedded 3-hydroxyflavone (3HF) dye molecules, that absorbs UV light and emits green light is presented. The thin films can be grown on sensitive substrates, including flexible polymers and paper. Their suitability as photonic active components in photonic devices is demonstrated.
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9.
  • Boschetti, P. J., et al. (creator_code:aut_t)
  • Nonlinear Aerodynamic Model in Dynamic Ground Effect at High Angles of Attack
  • 2022
  • record:In_t: Journal of Aircraft. - : AIAA International. - 0021-8669 .- 1533-3868. ; 59:6, s. 1500-1513
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • This paper focuses on the development of a model to represent the longitudinal aerodynamics of a wing and/or flight vehicle in ground effect when height is a function of time including high angles of attack. A general aerodynamic model of a wing and/or airplane in ground effect that includes high angles of attack was created. The aerodynamic coefficients of wings studied herein were obtained by the unsteady vortex-lattice method with Kirchhoff-based correction (UVLM-K). The wind-tunnel measurements presented in the literature were used to validate the UVLM-K. Then, a rectangular wing was simulated at high angles of attack in takeoff and flare, and the aerodynamic characteristics at different heights above ground were obtained along with the h derivatives during these maneuvers. The mathematical model presented herein is capable of modeling unsteady aerodynamic phenomena in ground effect at high angles of attack. When this model was used in the static ground effect, values of R2 equal to or greater than 0.999, 0.981, and 0.993 were obtained for lift, induced drag, and pitching moment coefficients, respectively. In the dynamic ground effect, the model can adjust the aerodynamic coefficient during the maneuvers. 
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