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Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
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- Melin, Beatrice S. (author)
- Umeå universitet,Institutionen för strålningsvetenskaper
- Barnholtz-Sloan, Jill S. (author)
- Wrensch, Margaret R. (author)
- show more...
- Johansen, Christoffer (author)
- Il'yasova, Dora (author)
- Kinnersley, Ben (author)
- Ostrom, Quinn T. (author)
- Labreche, Karim (author)
- Chen, Yanwen (author)
- Armstrong, Georgina (author)
- Liu, Yanhong (author)
- Eckel-Passow, Jeanette E. (author)
- Decker, Paul A. (author)
- Labussiere, Marianne (author)
- Idbaih, Ahmed (author)
- Hoang-Xuan, Khe (author)
- Di Stefano, Anna-Luisa (author)
- Mokhtari, Karima (author)
- Delattre, Jean-Yves (author)
- Broderick, Peter (author)
- Galan, Pilar (author)
- Gousias, Konstantinos (author)
- Schramm, Johannes (author)
- Schoemaker, Minouk J. (author)
- Fleming, Sarah J. (author)
- Herms, Stefan (author)
- Heilmann, Stefanie (author)
- Noethen, Markus M. (author)
- Wichmann, Heinz-Erich (author)
- Schreiber, Stefan (author)
- Swerdlow, Anthony (author)
- Lathrop, Mark (author)
- Simon, Matthias (author)
- Sanson, Marc (author)
- Rajaraman, Preetha (author)
- Chanock, Stephen (author)
- Linet, Martha (author)
- Wang, Zhaoming (author)
- Yeager, Meredith (author)
- Wiencke, John K. (author)
- Hansen, Helen (author)
- Mccoy, Lucie (author)
- Rice, Terri (author)
- Kosel, Matthew L. (author)
- Sicotte, Hugues (author)
- Amos, Christopher I. (author)
- Bernstein, Jonine L. (author)
- Davis, Faith (author)
- Lachance, Dan (author)
- Lau, Ching (author)
- Merrell, Ryan T. (author)
- Shildkraut, Joellen (author)
- Ali-Osman, Francis (author)
- Sadetzki, Siegal (author)
- Scheurer, Michael (author)
- Shete, Sanjay (author)
- Lai, Rose K. (author)
- Claus, Elizabeth B. (author)
- Olson, Sara H. (author)
- Jenkins, Robert B. (author)
- Houlston, Richard S. (author)
- Bondy, Melissa L. (author)
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- (creator_code:org_t)
- 2017-03-27
- 2017
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:5, s. 789-794
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- Melin, Beatrice ...
- Barnholtz-Sloan, ...
- Wrensch, Margare ...
- Johansen, Christ ...
- Il'yasova, Dora
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- show more...
- Ostrom, Quinn T.
- Labreche, Karim
- Chen, Yanwen
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- Chanock, Stephen
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- Lachance, Dan
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