Sökning: WFRF:(Graf Wilhelm)
> (2015-2019)
> (2016)
> Glimelius Bengt >
Cytoreductive surge...
Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases : A randomised trial
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- Cashin, Peter H. (författare)
- Uppsala universitet,Kolorektalkirurgi
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- Mahteme, Haile (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Canc Clin, Uppsala, Sweden.
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- Spang, N. (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Syk, Ingvar (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Frodin, J. E. (författare)
- Karolinska Institutet
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- Torkzad, Michael (författare)
- Uppsala universitet,Radiologi
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- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Pathol & Oncol, S-17176 Stockholm, Sweden.
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- Graf, Wilhelm (författare)
- Uppsala universitet,Kolorektalkirurgi
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 53, s. 155-162
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: First-line treatment of isolated resectable colorectal peritoneal metastases remains unclear. This study (the Swedish peritoneal study) compares cytoreductive surgery and intraperitoneal chemotherapy (surgery arm) with systemic chemotherapy (chemotherapy arm). Methods: Patients deemed resectable preoperatively were randomised to surgery and intraperitoneal 5-fluorouracil 550 mg/m(2) /d for 6 d with repeated courses every month or to systemic oxaliplatin and 5-fluorouracil regimen every second week. Both treatments continued for 6 months. Primary end-point was overall survival (OS) and secondary end-points were progression-free survival (PFS), and morbidity. Results: The study terminated prematurely when 48 eligible patients (24/arm) were included due to recruitment difficulties. Two-year OS was 54% in the surgery arm and 38% in the chemotherapy arm (p = 0.04). After 5 years, 8 versus 1 patient were alive, respectively (p = 0.02). Median OS was 25 months versus 18 months, respectively, hazard ratio 0.51 (95% confidence interval: 0.27-0.96, p = 0.04). PFS in the surgery arm was 12 months versus 11 months in the chemotherapy arm (p = 0.16) with 17% versus 0% 5-year PFS. Grade III-IV morbidity was seen in 42% and 50% of the patients, respectively. No mortalities. Conclusions: Cytoreductive surgery with intraperitoneal chemotherapy may be superior to systemic oxaliplatin-based treatment of colorectal cancer with resectable isolated peritoneal metastases.(ClinicalTrials. gov nr: NCT01524094).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cytoreductive surgery
- Intraperitoneal chemotherapy
- Colorectal cancer
- Systemic chemotherapy
- Peritoneal metastases
- Peritoneal carcinomatosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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