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> (2010-2014)
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Quality of life in ...
Quality of life in peritoneal carcinomatosis after cytoreductive surgery and intraperitoneal chemotherapy
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- Hansson, Johan, 1964- (författare)
- Uppsala universitet,Kolorektalkirurgi,PC-gruppen
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- Graf, Wilhelm (författare)
- Uppsala universitet,Kolorektalkirurgi
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- Nygren, Peter (författare)
- Uppsala universitet,Enheten för onkologi,Nygren
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visa fler...
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- Ring, Lena (författare)
- Uppsala universitet,Institutionen för farmaci
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- Glimelius, Bengt (författare)
- Uppsala universitet,Enheten för onkologi
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visa färre...
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background:Cytoreductive surgery (CRS) plus intraperitoneal chemotherapy (IPC) is considered the most optimal treatment for peritoneal carcinomatosis (PC). Health-related quality of life (HRQL) after treatment is largely unknown. The aims were to assess HRQL in patients with PC treated with CRS and IPC and to analyse the influence of clinical variables on HRQL.Methods:HRQL was assessed prospectively between November 2001 and March 2005 in 64 consecutive patients with PC through two different self-administered instruments, EORTC QLQ-C30 v3.0 (QLQ-C30) and the SF-36 Health Survey (SF-36), preoperatively, and after 3 and 8 months. Results:For QLQ-C30, 44 (69%) and for SF-36, 42 (66%) out of 64 patients had a complete follow-up. Most scales were worsened at baseline compared to reference in both instruments. HRQL was reduced at 3-months in QLQ-C30 (physical, role and emotional functioning) and in SF-36 (physical summary score). At 8-months, all scales returned to baseline in QLQ-C30, except physical functioning which was still reduced and dyspnoea that was worsened. In SF-36, all values returned to baseline levels. At 8-months, presence of a stoma worsened social functioning and a high peritoneal cancer index decreased social functioning and global QoL, the use of hyperthermic intraperitoneal chemotherapy and 30-days postoperative morbidity had no impact on HRQL. Conclusion: CRS with IPC results in reasonable short-term HRQL despite high initial morbidity and an initial decrease in HRQL parameters. The study adds to the notion that this treatment appears beneficial in light of probable life prolongation, despite considerable toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Health Related Quality of Life
- Cytoreductive surgery
- Intraperitoneal Chemotherapy
- Peritoneal Carcinomatosis
- Stoma
- PCI
- and Adverse Events
- Surgery
- Kirurgi
- Surgery
- Kirurgi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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