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Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

Lindgren, Cecilia M (author)
Heid, Iris M (author)
Randall, Joshua C (author)
show more...
Lamina, Claudia (author)
Steinthorsdottir, Valgerdur (author)
Qi, Lu (author)
Speliotes, Elizabeth K (author)
Thorleifsson, Gudmar (author)
Willer, Cristen J (author)
Herrera, Blanca M (author)
Jackson, Anne U (author)
Lim, Noha (author)
Scheet, Paul (author)
Soranzo, Nicole (author)
Amin, Najaf (author)
Aulchenko, Yurii S (author)
Chambers, John C (author)
Drong, Alexander (author)
Luan, Jian'an (author)
Lyon, Helen N (author)
Rivadeneira, Fernando (author)
Sanna, Serena (author)
Timpson, Nicholas J (author)
Zillikens, M Carola (author)
Zhao, Jing Hua (author)
Almgren, Peter (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Bandinelli, Stefania (author)
Bennett, Amanda J (author)
Bergman, Richard N (author)
Bonnycastle, Lori L (author)
Bumpstead, Suzannah J (author)
Chanock, Stephen J (author)
Cherkas, Lynn (author)
Chines, Peter (author)
Coin, Lachlan (author)
Cooper, Cyrus (author)
Crawford, Gabriel (author)
Doering, Angela (author)
Dominiczak, Anna (author)
Doney, Alex S F (author)
Ebrahim, Shah (author)
Elliott, Paul (author)
Erdos, Michael R (author)
Estrada, Karol (author)
Ferrucci, Luigi (author)
Fischer, Guido (author)
Forouhi, Nita G (author)
Gieger, Christian (author)
Grallert, Harald (author)
Groves, Christopher J (author)
Grundy, Scott (author)
Guiducci, Candace (author)
Hadley, David (author)
Hamsten, Anders (author)
Karolinska Institutet
Havulinna, Aki S (author)
Hofman, Albert (author)
Holle, Rolf (author)
Holloway, John W (author)
Illig, Thomas (author)
Isomaa, Bo (author)
Jacobs, Leonie C (author)
Jameson, Karen (author)
Jousilahti, Pekka (author)
Karpe, Fredrik (author)
Kuusisto, Johanna (author)
Laitinen, Jaana (author)
Lathrop, G Mark (author)
Lawlor, Debbie A (author)
Mangino, Massimo (author)
McArdle, Wendy L (author)
Meitinger, Thomas (author)
Morken, Mario A (author)
Morris, Andrew P (author)
Munroe, Patricia (author)
Narisu, Narisu (author)
Nordström, Anna (author)
Umeå universitet,Idrottsmedicin,Geriatrik
Nordström, Peter (author)
Umeå universitet,Idrottsmedicin,Geriatrik
Oostra, Ben A (author)
Palmer, Colin N A (author)
Payne, Felicity (author)
Peden, John F (author)
Prokopenko, Inga (author)
Renström, Frida (author)
Umeå universitet,Medicin
Ruokonen, Aimo (author)
Salomaa, Veikko (author)
Sandhu, Manjinder S (author)
Scott, Laura J (author)
Scuteri, Angelo (author)
Silander, Kaisa (author)
Song, Kijoung (author)
Yuan, Xin (author)
Stringham, Heather M (author)
Swift, Amy J (author)
Tuomi, Tiinamaija (author)
Uda, Manuela (author)
Vollenweider, Peter (author)
Waeber, Gerard (author)
Wallace, Chris (author)
Walters, G Bragi (author)
Weedon, Michael N (author)
Witteman, Jacqueline C M (author)
Zhang, Cuilin (author)
Zhang, Weihua (author)
Caulfield, Mark J (author)
Collins, Francis S (author)
Davey Smith, George (author)
Day, Ian N M (author)
Franks, Paul W (author)
Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Hattersley, Andrew T (author)
Hu, Frank B (author)
Jarvelin, Marjo-Riitta (author)
Kong, Augustine (author)
Kooner, Jaspal S (author)
Laakso, Markku (author)
Lakatta, Edward (author)
Mooser, Vincent (author)
Morris, Andrew D (author)
Peltonen, Leena (author)
Samani, Nilesh J (author)
Spector, Timothy D (author)
Strachan, David P (author)
Tanaka, Toshiko (author)
Tuomilehto, Jaakko (author)
Uitterlinden, André G (author)
van Duijn, Cornelia M (author)
Wareham, Nicholas J (author)
Waterworth, Dawn M (author)
Boehnke, Michael (author)
Deloukas, Panos (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Hunter, David J (author)
Thorsteinsdottir, Unnur (author)
Schlessinger, David (author)
Wichmann, H-Erich (author)
Frayling, Timothy M (author)
Abecasis, Gonçalo R (author)
Hirschhorn, Joel N (author)
Loos, Ruth J F (author)
Stefansson, Kari (author)
Mohlke, Karen L (author)
Barroso, Inês (author)
McCarthy, Mark I (author)
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 (creator_code:org_t)
2009-06-26
2009
English.
In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 5:6, s. e1000508-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Lindgren, Cecili ...
Heid, Iris M
Randall, Joshua ...
Lamina, Claudia
Steinthorsdottir ...
Qi, Lu
show more...
Speliotes, Eliza ...
Thorleifsson, Gu ...
Willer, Cristen ...
Herrera, Blanca ...
Jackson, Anne U
Lim, Noha
Scheet, Paul
Soranzo, Nicole
Amin, Najaf
Aulchenko, Yurii ...
Chambers, John C
Drong, Alexander
Luan, Jian'an
Lyon, Helen N
Rivadeneira, Fer ...
Sanna, Serena
Timpson, Nichola ...
Zillikens, M Car ...
Zhao, Jing Hua
Almgren, Peter
Bandinelli, Stef ...
Bennett, Amanda ...
Bergman, Richard ...
Bonnycastle, Lor ...
Bumpstead, Suzan ...
Chanock, Stephen ...
Cherkas, Lynn
Chines, Peter
Coin, Lachlan
Cooper, Cyrus
Crawford, Gabrie ...
Doering, Angela
Dominiczak, Anna
Doney, Alex S F
Ebrahim, Shah
Elliott, Paul
Erdos, Michael R
Estrada, Karol
Ferrucci, Luigi
Fischer, Guido
Forouhi, Nita G
Gieger, Christia ...
Grallert, Harald
Groves, Christop ...
Grundy, Scott
Guiducci, Candac ...
Hadley, David
Hamsten, Anders
Havulinna, Aki S
Hofman, Albert
Holle, Rolf
Holloway, John W
Illig, Thomas
Isomaa, Bo
Jacobs, Leonie C
Jameson, Karen
Jousilahti, Pekk ...
Karpe, Fredrik
Kuusisto, Johann ...
Laitinen, Jaana
Lathrop, G Mark
Lawlor, Debbie A
Mangino, Massimo
McArdle, Wendy L
Meitinger, Thoma ...
Morken, Mario A
Morris, Andrew P
Munroe, Patricia
Narisu, Narisu
Nordström, Anna
Nordström, Peter
Oostra, Ben A
Palmer, Colin N ...
Payne, Felicity
Peden, John F
Prokopenko, Inga
Renström, Frida
Ruokonen, Aimo
Salomaa, Veikko
Sandhu, Manjinde ...
Scott, Laura J
Scuteri, Angelo
Silander, Kaisa
Song, Kijoung
Yuan, Xin
Stringham, Heath ...
Swift, Amy J
Tuomi, Tiinamaij ...
Uda, Manuela
Vollenweider, Pe ...
Waeber, Gerard
Wallace, Chris
Walters, G Bragi
Weedon, Michael ...
Witteman, Jacque ...
Zhang, Cuilin
Zhang, Weihua
Caulfield, Mark ...
Collins, Francis ...
Davey Smith, Geo ...
Day, Ian N M
Franks, Paul W
Hattersley, Andr ...
Hu, Frank B
Jarvelin, Marjo- ...
Kong, Augustine
Kooner, Jaspal S
Laakso, Markku
Lakatta, Edward
Mooser, Vincent
Morris, Andrew D
Peltonen, Leena
Samani, Nilesh J
Spector, Timothy ...
Strachan, David ...
Tanaka, Toshiko
Tuomilehto, Jaak ...
Uitterlinden, An ...
van Duijn, Corne ...
Wareham, Nichola ...
Waterworth, Dawn ...
Boehnke, Michael
Deloukas, Panos
Groop, Leif
Hunter, David J
Thorsteinsdottir ...
Schlessinger, Da ...
Wichmann, H-Eric ...
Frayling, Timoth ...
Abecasis, Gonçal ...
Hirschhorn, Joel ...
Loos, Ruth J F
Stefansson, Kari
Mohlke, Karen L
Barroso, Inês
McCarthy, Mark I
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
Articles in the publication
PLoS genetics
By the university
Umeå University
Karolinska Institutet
Lund University

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