| 1. |
- Lorefält, Birgitta, 1944-, et al.
(författare)
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Bone mass in elderly patients with Parkinson's disease
- 2007
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 116:4, s. 248-254
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Tidskriftsartikel (refereegranskat)abstract
- Objective - The objective of the present study was to find risk factors for low bone mineral density (BMD) in patients with Parkinson's disease (PD). Material and methods - Twenty-six PD patients and 26 age-and sex-matched healthy controls were assessed twice within a 1-year period. PD symptoms, body weight, body fat mass, BMD, physical activity, smoking and serum concentrations of several laboratory analyses were investigated. Results - BMD in different locations was lower in PD patients compared with their controls and decreased during the investigated year. BMD was lower in PD patients with low body weight. BMD Z-score of trochanter in the PD group was directly correlated to the degree of physical activity and indirectly to the length of recumbent rest. Total body BMD Z-score in the PD group was directly correlated to the degree of rigidity. Serum 25-hydroxy-vitamin D was slightly lower in PD patients. Conclusion - Low body weight and low physical activity were risk factors for low BMD in PD, while rigidity seemed to be protective. © 2007 The Authors.
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| 2. |
- Lorefält, Birgitta, et al.
(författare)
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Factors of importance for weight loss in elderly patients with Parkinson's disease
- 2004
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 110:3, s. 180-187
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Tidskriftsartikel (refereegranskat)abstract
- Objective – Weight loss is reported frequently in patients with Parkinson's disease (PD). The objective of this study was to find the underlying factors of this phenomenon.Participants and methods – Twenty-six l-dopa-treated patients with PD and 26 age- and sex-matched healthy controls were assessed twice within a 1-year interval. Body weight, body fat mass, resting energy expenditure, physical activity, energy intake, thyroid hormones and cognitive function were investigated.Results – Nineteen (73%) of the PD patients lost body weight, although energy intake and the time for rest increased. Weight loss was most marked in patients with more severe PD symptoms and in whom cognitive function had decreased. Multiple regression analyses showed that determinants for weight loss were female gender, age and low physical activity.Conclusion – Weight loss was common in PD patients, in spite of the increased energy intake and was most obvious in patients with increased PD symptoms and decreased cognitive function.
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| 3. |
- Lorefält, Birgitta, et al.
(författare)
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Weight Loss, Body Fat Mass, and Leptin in Parkinsons Disease
- 2009
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Ingår i: MOVEMENT DISORDERS. - : Wiley. - 0885-3185 .- 1531-8257. ; 24:6, s. 885-890
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Tidskriftsartikel (refereegranskat)abstract
- Weight loss is a common problem in Parkinsons disease (PD), but the causative mechanisms behind this weight loss are unclear. We compared 2( PD patients with sex and age matched healthy controls. Examinations were repeated at baseline, after one and after two years. Body fat mass was measured by Dual X-ray Absorptiometry (DXA). Seventy three per cent of the PD patients lost body weight. Loss of body fat mass constituted a considerable part of the loss of body weight. In the patients who lost weight, serum leptin levels were lower than in those who did not lose weight. The relationship between low body fat mass and low leptin levels seems to be relevant, at least for female PD patients. It is reasonable to believe that low leptin levels in these patients could be secondary to the decreased body fat mass.
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| 4. |
- Pålhagen, Sven, 1943-, et al.
(författare)
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Does l-dopa treatment contribute to reduction in body weight in elderly patients with Parkinson's disease?
- 2005
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 111:1, s. 12-20
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Tidskriftsartikel (refereegranskat)abstract
- Objective – Many patients with Parkinson's disease (PD) lose weight also early during the disease. The objective of the study was to investigate possible causative factors for this loss.Materials and methods – In this report, 28 PD patients and 28 age- and sex-matched controls were repeatedly assessed with the focus on body weight, body fat mass, dysphagia, olfaction, physical activity, PD symptomatology and drug treatment.Results – Weight loss was seen in PD patients both before and during l-dopa treatment.Conclusion – The underlying disease could play a role, but our results also suggest that l-dopa per se could contribute to the weight loss.
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