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Genome of the marsu...
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
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Mikkelsen, Tarjei S (author)
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Wakefield, Matthew J (author)
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Aken, Bronwen (author)
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Amemiya, Chris T (author)
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Chang, Jean L (author)
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Duke, Shannon (author)
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Garber, Manuel (author)
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Gentles, Andrew J (author)
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Goodstadt, Leo (author)
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Heger, Andreas (author)
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Jurka, Jerzy (author)
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Kamal, Michael (author)
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Mauceli, Evan (author)
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Searle, Stephen M J (author)
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Sharpe, Ted (author)
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Baker, Michelle L (author)
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Batzer, Mark A (author)
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Benos, Panayiotis V (author)
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Belov, Katherine (author)
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Clamp, Michele (author)
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Cook, April (author)
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Cuff, James (author)
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Das, Radhika (author)
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Davidow, Lance (author)
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Deakin, Janine E (author)
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Fazzari, Melissa J (author)
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Glass, Jacob L (author)
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Grabherr, Manfred (author)
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Greally, John M (author)
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Gu, Wanjun (author)
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Hore, Timothy A (author)
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Huttley, Gavin A (author)
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Kleber, Michael (author)
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Jirtle, Randy L (author)
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Koina, Edda (author)
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Lee, Jeannie T (author)
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Mahony, Shaun (author)
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Marra, Marco A (author)
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Miller, Robert D (author)
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Nicholls, Robert D (author)
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Oda, Mayumi (author)
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Papenfuss, Anthony T (author)
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Parra, Zuly E (author)
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Pollock, David D (author)
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Ray, David A (author)
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Schein, Jacqueline E (author)
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Speed, Terence P (author)
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Thompson, Katherine (author)
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VandeBerg, John L (author)
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Wade, Claire M (author)
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Walker, Jerilyn A (author)
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Waters, Paul D (author)
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Webber, Caleb (author)
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Weidman, Jennifer R (author)
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Xie, Xiaohui (author)
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Zody, Michael C (author)
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Graves, Jennifer A Marshall (author)
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Ponting, Chris P (author)
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Breen, Matthew (author)
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Samollow, Paul B (author)
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Lander, Eric S (author)
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2007
- 2007
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7141, s. 167-177
- Related links:
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http://www.ncbi.nlm....
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.
Keyword
- Animals
- Base Composition
- Conserved Sequence/genetics
- DNA Transposable Elements/genetics
- Evolution; Molecular
- Genome/*genetics
- Genomics
- Humans
- Opossums/*genetics
- Polymorphism; Single Nucleotide/genetics
- Protein Biosynthesis
- Synteny/genetics
- X Chromosome Inactivation/genetics
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Mikkelsen, Tarje ...
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Wakefield, Matth ...
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Aken, Bronwen
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Amemiya, Chris T
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Chang, Jean L
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Duke, Shannon
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show more...
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Garber, Manuel
-
Gentles, Andrew ...
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Goodstadt, Leo
-
Heger, Andreas
-
Jurka, Jerzy
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Kamal, Michael
-
Mauceli, Evan
-
Searle, Stephen ...
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Sharpe, Ted
-
Baker, Michelle ...
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Batzer, Mark A
-
Benos, Panayioti ...
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Belov, Katherine
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Clamp, Michele
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Cook, April
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Cuff, James
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Das, Radhika
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Davidow, Lance
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Deakin, Janine E
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Fazzari, Melissa ...
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Glass, Jacob L
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Grabherr, Manfre ...
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Greally, John M
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Gu, Wanjun
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Hore, Timothy A
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Huttley, Gavin A
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Kleber, Michael
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Jirtle, Randy L
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Koina, Edda
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Lee, Jeannie T
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Mahony, Shaun
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Marra, Marco A
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Miller, Robert D
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Nicholls, Robert ...
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Oda, Mayumi
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Papenfuss, Antho ...
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Parra, Zuly E
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Pollock, David D
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Ray, David A
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Schein, Jacqueli ...
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Speed, Terence P
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Thompson, Kather ...
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VandeBerg, John ...
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Wade, Claire M
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Walker, Jerilyn ...
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Waters, Paul D
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Webber, Caleb
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Weidman, Jennife ...
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Xie, Xiaohui
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Zody, Michael C
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Graves, Jennifer ...
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Ponting, Chris P
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Breen, Matthew
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Samollow, Paul B
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Lander, Eric S
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Lindblad-Toh, Ke ...
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- Articles in the publication
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Nature
- By the university
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Uppsala University