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Sökning: WFRF:(Grigorenko E.L.)

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1.
  • Ruchkin, Vladislav V, et al. (författare)
  • Platelet MAO-B, personality, and psychopathology
  • 2005
  • Ingår i: Journal of Abnormal Psychology. - 0021-843X .- 1939-1846. ; 114:3, s. 477-482
  • Tidskriftsartikel (refereegranskat)abstract
    • The article investigates the relationships between platelet monoamine oxidase-B (MAO-B) activity, personality, and psychopathology (Diagnostic and Statistical Manual of Mental Disorders [4th ed.; American Psychiatric Association, 1994] diagnoses. These relationships were assessed in 178 incarcerated male juvenile delinquents. Even after controlling for smoking, the authors found that both Internalizing and Externalizing Psychopathology were negatively related to MAO-B activity. In the final reduced model, novelty seeking fully mediated the relationships between MAO-B and Externalizing Psychopathology but not between MAO-B and Internalizing Psychopathology. It was hypothesized that low platelet MAO-B activity does not directly predispose individuals to psychopathology but is related to specific personality traits, which in turn represent a vulnerability factor for psychopathology. Future studies should help clarify the nature of the relationships between personality, biological markers, and psychopathology.
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2.
  • DeYoung, C.G, et al. (författare)
  • Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
  • 2010
  • Ingår i: Psychiatric Genetics. - 0955-8829 .- 1473-5873. ; 20:1, s. 20-24
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method: This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results: The Val allele of the Val¹⁵⁸ Met polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion: The Val¹⁵⁸ Met polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.
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3.
  • Thompson, T.M, et al. (författare)
  • Genetic variation in DRD4, criminality and conduct disorder
  • 2011
  • Ingår i: Personality and individual differences. - New York : Nova Science Publishers Inc.. - 9781611225884
  • Bokkapitel (refereegranskat)abstract
    • Personality and individual differences research is relevant to practically every facet of human existence. For instance, since theories of persons either explicitly or implicitly guide clinical work, the field contributes to discussions of understanding abnormal psychology and provides a guide for conceptualising best treatment. Additionally, the field is relevant to understanding human development across the lifespan, and our understanding of personality and individual differences impacts upon our views of socialisation and interpersonal relations. This book presents research which draws attention to the rich scientific literature that continues to emerge with respect to personality and individual differences psychology.
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