| 1. |
- Pettersson, E., et al.
(författare)
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Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
- 2019
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Ingår i: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 49:7, s. 1166-1173
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.METHODS: We assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.RESULTS: Heritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.CONCLUSIONS: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.
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| 2. |
- Meyfroid, P., et al.
(författare)
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Middle-range theories of land system change
- 2018
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Ingår i: Global Environmental Change. - : Elsevier BV. - 0959-3780 .- 1872-9495. ; 53, s. 52-67
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Tidskriftsartikel (refereegranskat)abstract
- Changes in land systems generate many sustainability challenges. Identifying more sustainable land-use alternatives requires solid theoretical foundations on the causes of land-use/cover changes. Land system science is a maturing field that has produced a wealth of methodological innovations and empirical observations on land cover and land-use change, from patterns and processes to causes. We take stock of this knowledge by reviewing and synthesizing the theories that explain the causal mechanisms of land-use change, including systemic linkages between distant land-use changes, with a focus on agriculture and forestry processes. We first review theories explaining changes in land-use extent, such as agricultural expansion, deforestation, frontier development, and land abandonment, and changes in land-use intensity, such as agricultural intensification and disintensification. We then synthesize theories of higher-level land system change processes, focusing on: (i) land-use spillovers, including land sparing and rebound effects with intensification, leakage, indirect land-use change, and land-use displacement, and (ii) land-use transitions, defined as structural non-linear changes in land systems, including forest transitions. Theories focusing on the causes of land system changes span theoretically and epistemologically disparate knowledge domains and build from deductive, abductive, and inductive approaches. A grand, integrated theory of land system change remains elusive. Yet, we show that middle-range theories - defined here as contextual generalizations that describe chains of causal mechanisms explaining a well-bounded range of phenomena, as well as the conditions that trigger, enable, or prevent these causal chains -, provide a path towards generalized knowledge of land systems. This knowledge can support progress towards sustainable social-ecological systems.
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| 3. |
- Zhou, Weiqi, et al.
(författare)
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Urban tree canopy has greater cooling effects in socially vulnerable communities in the US
- 2021
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Ingår i: One Earth. - : Elsevier BV. - 2590-3330 .- 2590-3322. ; 4:12, s. 1764-1775
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Tidskriftsartikel (refereegranskat)abstract
- Cities are home to around half of the global population but face intensified and unevenly distributed heat stresses. Trees are utilized to adapt to urban heat; however, most tree planting is prioritized by either biophysical or social metrics, rather than an integration of the two. It therefore remains unclear how to maximize ecological and social benefits of tree planting in the context of environmental justice. Here, we analyze social vulnerability to heat and the cooling capacity of trees across 38 of the largest cities in the United States. We find that socially vulnerable people tend to live in hotter neighborhoods with less tree canopy. Furthermore, tree planting in such neighborhoods can achieve greater cooling benefits per unit increase in canopy. Increasing tree cover in these neighborhoods will meet the greatest need for cooling and achieve greater cooling capacity, creating social and ecological co-benefits. Adaptation measures must address both the distributional injustices of urban heat and procedural justice in planning and managing nature-based cooling approaches.
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| 4. |
- Metson, Genevieve, 1988-, et al.
(författare)
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Urban phosphorus sustainability: Systemically incorporating social, ecological, and technological factors into phosphorus flow analysis
- 2015
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Ingår i: Environmental Science and Policy. - : Elsevier. - 1462-9011 .- 1873-6416. ; 47, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Phosphorus (P) is an essential fertilizer for agricultural production but is also a potent aquatic pollutant. Current P management fails to adequately address both the issue of food security due to P scarcity and P pollution threats to water bodies. As centers of food consumption and waste production, cities transport and store much P and thus provide important opportunities to improve P management. Substance flow analysis (SFA) is often used to understand urban P cycling and to identify inefficiencies that may be improved on. However, SFAs typically do not examine the factors that drive observed P dynamics. Understanding the social, ecological, and technological context of P stocks and flows is necessary to link urban P management to existing urban priorities and to select local management options that minimize tradeoffs and maximize synergies across priorities. Here, we review P SFA studies in 18 cities, focusing on gaps in the knowledge required to implement P management solutions. We develop a framework to systemically explore the full suite of factors that drive P dynamics in urban systems. By using this framework, scientists and managers can build a better understanding of the drivers of P cycling and improve our ability to address unsustainable P use and waste.
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