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- Grubb, Anders, et al.
(författare)
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Använd ekvationer utan »ras«- termer för att bestämma GFR
- 2022
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Ingår i: Läkartidningen. - 0023-7205. ; 119:21212
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Forskningsöversikt (refereegranskat)abstract
- Glomerular filtration rate (GFR) is estimated by creatinine or cystatin C-based GFR-estimating equations. Those based upon creatinine, but not those based upon cystatin C, use ”race” terms due to that different populations differ in average muscular mass, influencing the creatinine, but not the cystatin C, level. “Race” is not a biological, but a sociological term, determined by self-assesment. New international studies therefore strongly recommend use of cystatin C-based GFR- estimating equations.
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| 2. |
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| 3. |
- Jonsson, M, et al.
(författare)
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Plasmaproteiner, inflammation och amyloidos
- 2018. - 10
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Ingår i: Laurells klinisk kemi i praktisk medicin.. - Lund : Studentlitteratur AB. - 9789144119748 ; , s. 87-130
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Bokkapitel (refereegranskat)
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| 4. |
- Nyman, Ulf, et al.
(författare)
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Så kan formel för vuxna skatta glomerulär filtration hos barn
- 2021
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Ingår i: Lakartidningen. - 0023-7205. ; 118
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Tidskriftsartikel (refereegranskat)abstract
- Age-adjustment of creatinine, i.e. recalculation of childhood levels of creatinine to corresponding levels at 18 years of age and applied in the adult revised Lund-Malmö GFR equation led to markedly improved accuracy in Swedish children (n=1 718) at measured GFR <75 mL/min/1.73 m2 (n=318) and preserved high accuracy at ≥75 mL/min/1.73 m2 (n=1 400). The adjusted LMR equation performed as well as dedicated paediatric equations based on height. The proposed adjustment strategy has four strengths: (i) the original coefficients of the adult GFR equation can be used, (ii) the same equation can be used across the entire lifespan without artificial changes in estimated GFR when switching from paediatric to adult care, (iii) the lack of height factor makes it easier to automatically report estimated GFR by the laboratories and (iv) age-adjusted creatinine values imply that well-established creatinine reference intervals for adults can also be used for children.
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| 5. |
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| 6. |
- Grubb, Anders
(författare)
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Krympt por-syndrom – ett nyupptäckt syndrom med hög prevalens och mortalitet
- 2019
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Ingår i: Läkartidningen. - 0023-7205. ; 116
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Forskningsöversikt (refereegranskat)abstract
- Shrunken Pore Syndrome was defined in 2015 and is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The diagnose is based upon identification of a decreased eGFRcystatin C/eGFRcreatinine ratio, and ratios -< 0.6 or 0.7 have most often been used to identify the diagnose. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The prevalence of the syndrome varies with the eGFRcystatin C/eGFRcreatinine ratio used for diagnosis, but when a ratio of 0.6 is used, the prevalence has varied between 2 and 8%. The pathophysiology might be the accumulation of atherosclerosis-promoting proteins occurring in patients with the syndrome. The syndrome might explain the superiority of eGFRcystatin C over eGFRcreatinine in identifying high-risk kidney patients.
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