Search: WFRF:(Gruenblatt E)
> Hampel H. >
Consensus Paper of ...
Consensus Paper of the WFSBP Task Force on Biological Markers of Dementia : The role of CSF and blood analysis in the early and differential diagnosis of dementia
-
Wiltfang, J. (author)
-
Lewczuk, P. (author)
-
Riederer, P. (author)
-
show more...
-
Gruenblatt, E. (author)
-
Hock, C. (author)
-
Scheltens, P. (author)
-
Hampel, H. (author)
-
Vanderstichele, H. (author)
-
Iqbal, K. (author)
-
Galasko, D. (author)
-
- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
-
Otto, M. (author)
-
Esselman, H. (author)
-
Henkel, A. W. (author)
-
Kornhuber, J. (author)
-
Blennow, K. (author)
-
show less...
-
(creator_code:org_t)
- 2009
- 2009
- English.
-
In: Revista de Psiquiatria Clinica. - 0101-6083. ; 36, s. 1-16
- Related links:
-
https://urn.kb.se/re...
Abstract
Subject headings
Close
- Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous system (e.g, neuroinflammation), or a disease currently considered irreversible (e.g, Alzheimer's disease, AD). In the latter case, several potentially successful treatment approaches are being tested now, demanding reasonable standards of pre-mortem diagnosis. Cerebrospinal fluid and serum analysis (CSF/serum analysis), whereas routinely performed in neuroinflammatory diseases, still requires standardization to be used as an aid to the clinically based diagnosis of AD. Several AD-related CSF parameters (total tau, phosphorylated forms of tau, A beta peptides, ApoE genotype, p97, etc.) tested separately or in a combination provide sensitivity and specificity in the range of 85%, the figure commonly expected from a good diagnostic tool. In this review, recently published reports regarding progress in neurochemical pre-mortem diagnosis of dementias are discussed with a focus on an early and differential diagnosis of AD. Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Dementia
- Alzheimer's disease
- neuroinflammation
- cerebrospinal fluid
- Psychiatry
- Psykiatri
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database
- By the author/editor
-
Wiltfang, J.
-
Lewczuk, P.
-
Riederer, P.
-
Gruenblatt, E.
-
Hock, C.
-
Scheltens, P.
-
show more...
-
Hampel, H.
-
Vanderstichele, ...
-
Iqbal, K.
-
Galasko, D.
-
Lannfelt, Lars
-
Otto, M.
-
Esselman, H.
-
Henkel, A. W.
-
Kornhuber, J.
-
Blennow, K.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Revista de Psiqu ...
- By the university
-
Uppsala University