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Träfflista för sökning "WFRF:(Gusev Alexander) "

Sökning: WFRF:(Gusev Alexander)

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1.
  • Gusev, Alexander, et al. (författare)
  • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
  • 2016
  • Ingår i: Nature communications. - 2041-1723. ; 7, s. 10979
  • Tidskriftsartikel (refereegranskat)abstract
    • Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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3.
  • Litvinov, D. A., et al. (författare)
  • RadioAstron gravitational redshift experiment: Status update
  • 2018
  • Ingår i: 14th Marcel Grossman Meeting On Recent Developments in Theoretical and Experimental General Relativity, Astrophysics and Relativistic Field Theories, Proceedings. - 978-981322659-3 ; s. 3569-3575
  • Konferensbidrag (refereegranskat)abstract
    • A test of a cornerstone of general relativity, the gravitational redshift effect, is currently being conducted with the RadioAstron spacecraft, which is on a highly eccentric orbit around Earth. Using ground radio telescopes to record the spacecraft signal, synchronized to its ultra-stable on-board H-maser, we can probe the varying flow of time on board with unprecedented accuracy. The observations performed so far, currently being analyzed, have already allowed us to measure the effect with a relative accuracy of 4 × 10−4. We expect to reach 2.5 × 10−5 with additional observations in 2016, an improvement of almost a magnitude over the 40-year old result of the GP-A mission.
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4.
  • Litvinov, Dmitry, et al. (författare)
  • Probing the gravitational redshift with an Earth-orbiting satellite
  • 2018
  • Ingår i: Physics Letters, Section A: General, Atomic and Solid State Physics. - 0375-9601. ; 382:33, s. 2192-2198
  • Tidskriftsartikel (refereegranskat)abstract
    • We present an approach to testing the gravitational redshift effect using the RadioAstron satellite. The experiment is based on a modification of the Gravity Probe A scheme of nonrelativistic Doppler compensation and benefits from the highly eccentric orbit and ultra-stable atomic hydrogen maser frequency standard of the RadioAstron satellite. Using the presented techniques we expect to reach an accuracy of the gravitational redshift test of order 10−5, a magnitude better than that of Gravity Probe A. Data processing is ongoing, our preliminary results agree with the validity of the Einstein Equivalence Principle.
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5.
  • Rutter, Nick, et al. (författare)
  • Evaluation of forest snow processes models (SnowMIP2)
  • 2009
  • Ingår i: Journal of Geophysical Research. - 0148-0227. ; 114:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Thirty-three snowpack models of varying complexity and purpose were evaluated across a wide range of hydrometeorological and forest canopy conditions at five Northern Hemisphere locations, for up to two winter snow seasons. Modeled estimates of snow water equivalent (SWE) or depth were compared to observations at forest and open sites at each location. Precipitation phase and duration of above-freezing air temperatures are shown to be major influences on divergence and convergence of modeled estimates of the subcanopy snowpack. When models are considered collectively at all locations, comparisons with observations show that it is harder to model SWE at forested sites than open sites. There is no universal "best'' model for all sites or locations, but comparison of the consistency of individual model performances relative to one another at different sites shows that there is less consistency at forest sites than open sites, and even less consistency between forest and open sites in the same year. A good performance by a model at a forest site is therefore unlikely to mean a good model performance by the same model at an open site (and vice versa). Calibration of models at forest sites provides lower errors than uncalibrated models at three out of four locations. However, benefits of calibration do not translate to subsequent years, and benefits gained by models calibrated for forest snow processes are not translated to open conditions.
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