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Träfflista för sökning "WFRF:(Gustafson Lars) ;pers:(Hultberg Björn)"

Sökning: WFRF:(Gustafson Lars) > Hultberg Björn

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  • Hultberg, Björn, et al. (författare)
  • Homocystein--markör för kärlsjukdom hos aldre med psykisk sjukdom.
  • 2008
  • Ingår i: Läkartidningen. - 0023-7205. ; 105:38, s. 2576-2578
  • Forskningsöversikt (refereegranskat)abstract
    • Many studies have reported higher total plasma homocysteine (tHcy) in elderly patients with mental illness than in control subjects. There are many different determinants of plasma tHcy concentration, including age, cobalamin/folate status, renal function and the presence of vascular disease. The presence of vascular disease may contribute to cognitive impairment. We have investigated elderly patients with regard to plasma tHcy and the presence of vascular disease. Clarification of the role of vascular risk factors in mental illness is important because most are modifiable, in contrast to other risk factors such as age and genetics. The main findings in our studies imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis. Furthermore, it seems possible that the control of conventional vascular risk factors could be guided by the level of plasma tHcy, serum cystatin C, and serum N-terminal pro-brain natriuretic peptide. Patients with an elevation of any of these parameters could be selected for a lower target level of vascular risk factors such as blood pressure cholesterol etc. than conventional target levels.
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  • Hultberg, Björn, et al. (författare)
  • Markers for the functional availability of cobalamin/folate and their association with neuropsychiatric symptoms in the elderly
  • 2001
  • Ingår i: International Journal of Geriatric Psychiatry. - : Wiley. - 1099-1166 .- 0885-6230. ; 16:9, s. 873-878
  • Tidskriftsartikel (refereegranskat)abstract
    • Cobalamin/folate deficiency is common in elderly subjects and may lead to psychiatric symptoms, but even more often it increases the severity of other organic and non-organic mental diseases. This paper reviews the literature relevant for markers of cobalamin/folate status and their relation to neuropsychiatric symptoms in the elderly. Plasma homocysteine, a marker of cobalamin/folate status, is frequently increased in psychogeriatric patients. Among markers of cobalamin/folate status, plasma homocysteine shows the best association with neuropsychiatric dysfunction.
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  • Nilsson, Anna-Karin, et al. (författare)
  • C-reactive protein: vascular risk marker in elderly patients with mental illness.
  • 2008
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 26:3, s. 251-256
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics. METHODS: In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease. RESULTS: Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment. CONCLUSION: The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP.
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6.
  • Nilsson, Karin, et al. (författare)
  • Association between plasma homocysteine levels and mortality in elderly patients with mental illness.
  • 2009
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 27:6, s. 579-583
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND/METHOD: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown to predict mortality in human subjects. Epidemiological data on this topic in elderly patients with mental illness are missing. We therefore investigated the association between plasma tHcy levels and mortality in these patients. RESULTS: The group of deceased patients showed higher age, higher plasma tHcy, lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. CONCLUSION: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy determinants age and presence of vascular disease. The determination of plasma tHcy in elderly patients with mental illness may help to identify patients in need of more intensive treatment.
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7.
  • Nilsson, Karin, et al. (författare)
  • C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time.
  • 2011
  • Ingår i: Clinical Biochemistry. - : Elsevier BV. - 1873-2933 .- 0009-9120. ; 44, s. 1205-1208
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness. METHODS: We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time. RESULTS: Patients with AD showed overall lower CRP levels than other patients with mental illness, but elevated CRP levels in these patients were associated with lower cognitive function and shorter survival time. CONCLUSION: The reason for an overall low CRP level is not obvious. Elevated CRP level in patients with AD suggests the presence of inflammatory activity in this subgroup of patients that may benefit from anti-inflammatory administration.
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  • Nilsson, Karin, et al. (författare)
  • Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis
  • 2007
  • Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 24:3, s. 162-168
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Plasma total homocysteine (tHcy) is often elevated in patients with mental illness. Since patients with mental illness and vascular disease exhibit a higher plasma tHcy concentration than patients without vascular disease, it is possible that elevated plasma tHcy in mental illness is mainly due to concomitant vascular disease. Methods: We have investigated plasma tHcy, cobalamin/folate status, renal function and the presence of vascular disease in patients with vascular dementia (VaD, n = 501), Alzheimer's disease ( AD, n = 300), depression ( n = 259) and in healthy subjects ( n = 144) stratified according to age ( below and above 75 years). Results: Plasma tHcy concentration showed the highest increase in patients with VaD compared to patients with AD or depression. After the exclusion of patients with cobalamin/ folate deficiencies and increased serum creatinine, patients with AD or depression above 75 years with vascular disease showed a similar elevation of plasma tHcy concentration as patients with VaD. Furthermore, patients with AD and depression without vascular disease showed a similar plasma tHcy concentration to healthy subjects. Conclusion: The findings imply that elevated plasma tHcy concentration in elderly patients with mental illness is mainly associated with the presence of vascular disease and is not related to the specific psychogeriatric diagnosis.
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