| 1. |
- Ulaszewska, Marynka M., et al.
(författare)
-
Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
- 2019
-
Ingår i: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 63:1
-
Forskningsöversikt (refereegranskat)abstract
- The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful “tips and tricks” along the analytical workflow.
|
|
| 2. |
|
|
| 3. |
- Bergström, Anders, et al.
(författare)
-
Origins and genetic legacy of prehistoric dogs
- 2020
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 370:6516, s. 557-563
-
Tidskriftsartikel (refereegranskat)abstract
- Dogs were the first domestic animal, but little is known about their population history and to what extent it was linked to humans. We sequenced 27 ancient dog genomes and found that all dogs share a common ancestry distinct from present-day wolves, with limited gene flow from wolves since domestication but substantial dog-to-wolf gene flow. By 11,000 years ago, at least five major ancestry lineages had diversified, demonstrating a deep genetic history of dogs during the Paleolithic. Coanalysis with human genomes reveals aspects of dog population history that mirror humans, including Levant-related ancestry in Africa and early agricultural Europe. Other aspects differ, including the impacts of steppe pastoralist expansions in West and East Eurasia and a near-complete turnover of Neolithic European dog ancestry.
|
|
| 4. |
- Madison, Guy, et al.
(författare)
-
Feltänkt om akademisk frihet
- 2014
-
Ingår i: Uppsala Nya Tidning. - 1104-0173.
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 5. |
- Racine, Eric, et al.
(författare)
-
Can Neuroscience contribute to practical ethics? : A critical review and discussion of the methodological and translational challenges of the neuroscience of ethics
- 2017
-
Ingår i: Bioethics. - : Wiley. - 0269-9702 .- 1467-8519. ; 2017:31, s. 328-337
-
Tidskriftsartikel (refereegranskat)abstract
- Neuroethics is an interdisciplinary field that arose in response to novel ethical challenges posed by advances in neuroscience. Historically, neuroethics has provided an opportunity to synergize different disciplines, notably proposing a two-way dialogue between an "ethics of neuroscience" and a "neuroscience of ethics". However, questions surface as to whether a "neuroscience of ethics" is a useful and unified branch of research and whether it can actually inform or lead to theoretical insights and transferable practical knowledge to help resolve ethical questions. In this article, we examine why the neuroscience of ethics is a promising area of research and summarize what we have learned so far regarding its most promising goals and contributions. We then review some of the key methodological challenges which may have hindered the use of results generated thus far by the neuroscience of ethics. Strategies are suggested to address these challenges and improve the quality of research and increase neuroscience's usefulness for applied ethics and society at large. Finally, we reflect on potential outcomes of a neuroscience of ethics and discuss the different strategies that could be used to support knowledge transfer to help different stakeholders integrate knowledge from the neuroscience of ethics.
|
|
| 6. |
|
|
| 7. |
- Lansing, J. Stephen, et al.
(författare)
-
Kinship structures create persistent channels for language transmission
- 2017
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 114:49, s. 12910-12915
-
Tidskriftsartikel (refereegranskat)abstract
- Languages are transmitted through channels created by kinship systems. Given sufficient time, these kinship channels can change the genetic and linguistic structure of populations. In traditional societies of eastern Indonesia, finely resolved cophylogenies of languages and genes reveal persistent movements between stable speech communities facilitated by kinship rules. When multiple languages are present in a region and post-marital residence rules encourage sustained directional movement between speech communities, then languages should be channeled along uniparental lines. We find strong evidence for this pattern in 982 individuals from 25 villages on two adjacent islands, where different kinship rules have been followed. Core groups of close relatives have stayed together for generations, while remaining in contact with, and marrying into, surrounding groups. Over time, these kinship systems shaped their gene and language phylogenies: Consistently following a postmarital residence rule turned social communities into speech communities.
|
|
| 8. |
- Madison, Guy, et al.
(författare)
-
Akademin är alls inte fri
- 2014
-
Ingår i: Uppsala Nya Tidning. - 1104-0173.
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 9. |
|
|
| 10. |
|
|
