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- Sun, Chengjun, et al.
(författare)
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CRYAB-650 C>G (rs2234702) affects susceptibility to type 1 diabetes and IAA-positivity in Swedish population
- 2012
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Ingår i: Human Immunology. - : Elsevier. - 0198-8859 .- 1879-1166. ; 73:7, s. 759-766
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabetes (T1D).METHODS: Genotyping of SNPs in the promoter region of CRYAB gene was performed in a Swedish cohort containing 444 T1D patients and 350 healthy controls. Three SNPs were included in this study: CRYAB-652 A>G (rs762550), -650 C>G (rs2234702) and -249 C > G (rs14133). Two SNPs (CRYAB-652 and -650) were not included in previous genome wide association studies.RESULTS: CRYAB-650 (rs2234702)*C allele was significantly more frequent in patients than in controls (OR = 1.48, Pc = 0.03). CRYAB-650*C allele was associated with IAA positivity (OR = 8.17, Pc < 0.0001) and IA-2A positivity (OR = 2.14, Pc = 0.005) in T1D patients. This association with IAA was amplified by high-risk HLA carrier state (OR = 10.6, P < 0.0001). No association was found between CRYAB-650 and other autoantibody positivity (GADA and ICA). CRYAB haplotypes were also associated with IAA and IA-2A positivity (highest OR = 2.07 and 2.11, respectively), these associations remain in high HLA-risk T1D patients.CONCLUSIONS: CRYAB-650 was associated with T1D in the Swedish cohort we studied. CRYAB-650*C allele might confers susceptibility to the development of T1D. CRYAB-650 was also associated with the development of IAA-positivity in T1D patients, especially in those carrying T1D high-risk HLA haplotypes.
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| 2. |
- Lindblom, Cecilia, 1979-, et al.
(författare)
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Interdisciplinary work regarding nutrition and health in Swedish compulsory school : a survey study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The Swedish National Agency for Education state that implementation of education should involve possibilities for pupils to work interdisciplinary and experience knowledge in different ways. The aim of the study was to explore the presence of interdisciplinary work related to the content of nutrition and health in Swedish compulsory school, and factors influencing interdisciplinary work. To investigate this, two web-based nationwide questionnaires were sent out in 2014 to compulsory schools in Sweden. One questionnaire was aimed at teachers in five subjects: Home and Consumer Studies, Physical Education and Health, Biology, Chemistry, and Physics. The second questionnaire was aimed at head teachers. A total of 388 teachers and 216 head teachers answered the respective questionnaires. The study showed that 40% of the teachers and 59% of the head teachers reported that their school worked interdisciplinary regarding nutrition and health. Lack of time for planning and scheduling problems were seen as the main barriers by both teachers and head teachers. A pre-requisite for interdisciplinary work to be successful is that teachers have a chance to meet and plan, and the study indicate that frame factors have a critical impact on what is possible to perform regarding interdisciplinary work in Swedish schools. Improving the interdisciplinary work regarding nutrition and health might increase the potential for schools to achieve the overall goal of pupils gaining knowledge and understanding of the importance of their lifestyle for health, the environment and society.
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