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Träfflista för sökning "WFRF:(H. Olsson) ;lar1:(uu)"

Search: WFRF:(H. Olsson) > Uppsala University

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  • Jiang, X., et al. (author)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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  • Result 1-10 of 349
Type of publication
journal article (283)
conference paper (44)
other publication (6)
research review (5)
reports (3)
review (3)
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book (2)
doctoral thesis (2)
book chapter (1)
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Type of content
peer-reviewed (292)
other academic/artistic (55)
pop. science, debate, etc. (2)
Author/Editor
Olsson, N (55)
Blomgren, J (50)
Nilsson, L. (38)
Olsson, Håkan (31)
Olsson, H. (29)
Wolk, Alicja (29)
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Renberg, P-U (29)
Jonsson, O. (28)
Tibell, G. (25)
Chang-Claude, J (24)
Zorro, R. (22)
Zheng, W. (20)
Giles, GG (20)
Hopper, JL (20)
Southey, MC (20)
Fasching, PA (20)
Couch, FJ (20)
Haiman, CA (20)
Dork, T (20)
Pharoah, PDP (20)
Dennis, J (19)
Czene, K (19)
Anton-Culver, H (19)
Milne, RL (19)
Hamann, U (19)
Lambrechts, D (19)
Garcia-Closas, M (19)
Nevanlinna, H (19)
Easton, DF (19)
Bolla, MK (18)
Dunning, AM (18)
Beckmann, MW (18)
Chenevix-Trench, G (18)
Khusnutdinova, E (18)
Kraft, P (18)
Stone, J (18)
Rennert, G. (18)
Wang, Q. (17)
Wolk, A (17)
Olsson, Y (17)
Schmidt, MK (17)
Bojesen, SE (17)
Mannermaa, A (17)
Simard, J (17)
Devilee, P (17)
Chanock, SJ (17)
Jakubowska, A (17)
Schmutzler, RK (17)
John, EM (17)
Gago-Dominguez, M. (17)
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University
Karolinska Institutet (143)
Lund University (68)
University of Gothenburg (33)
Umeå University (23)
Linköping University (23)
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Swedish University of Agricultural Sciences (11)
Örebro University (10)
Royal Institute of Technology (7)
Stockholm University (5)
Linnaeus University (3)
Luleå University of Technology (2)
Jönköping University (2)
Södertörn University (2)
Chalmers University of Technology (2)
Swedish Museum of Natural History (2)
Kristianstad University College (1)
Mälardalen University (1)
University of Borås (1)
Högskolan Dalarna (1)
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Language
English (340)
Swedish (7)
Undefined language (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (150)
Natural sciences (41)
Engineering and Technology (10)
Agricultural Sciences (8)
Social Sciences (5)
Humanities (3)

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