| 1. |
- Craig, Marina, 1978, et al.
(författare)
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Polypeptide Multilayer Self-Assembly Studied by Ellipsometry
- 2014
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Ingår i: Journal of Drug Delivery. - : Hindawi Limited. - 2090-3014 .- 2090-3022. ; 2014, s. (article ID) 424697-
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Tidskriftsartikel (refereegranskat)abstract
- A polypeptide nanofilm made by layer-by-layer (LbL) self-assembly was built on a surface that mimics nonwoven, a material commonly used in wound dressings. Poly-L-lysine (PLL) and poly-L-glutamic acid (PLGA) are the building blocks of the nanofilm, which is intended as an enzymatically degradable lid for release of bactericides to chronic wounds. Chronic wounds often carry infection originating from bacteria such as Staphylococcus aureus and a release system triggered by the degree of infection is of interest. The dry nanofilm was studied with ellipsometry. The thickness of the nanofilm was 60% less in its dry state than in its wet state. The measurements showed that a primer was not necessary to build a stable nanofilm, which is practically important in our case because a nondegradable primer is highly unwanted in a wound care dressing. Added V8 (glutamyl endopeptidase) enzymes only showed adsorption on the nanofilm at room temperature, indicating that the PLL/PLGA “lid” may remain intact until the dressing has been filled with wound exudate at the elevated temperature typical of that of the wound.
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| 2. |
- Jain, T., et al.
(författare)
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Anisotropic growth of gold nanoparticles using cationic gemini surfactants: effects of structure variations in head and tail groups
- 2014
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Ingår i: Journal of Materials Chemistry C. - : Royal Society of Chemistry (RSC). - 2050-7534 .- 2050-7526. ; 2:6, s. 994-1003
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Tidskriftsartikel (refereegranskat)abstract
- A library of gemini surfactants is employed to study surfactant directed anisotropic growth of gold nanoparticles. The surfactants are modified with respect to the length and type of the tails, as well as of the spacer group. By analyzing the structure of the anisotropic nanoparticles, it is possible to extract information on how the structure of the surfactants influences the anisotropic gold nanocrystal growth. We find that the tail length of the surfactants has a greater influence on the resulting nanoparticle aspect ratio compared to the chemical nature of the spacer group. While clear trends between the aspect ratio and the tail as well as spacer length remain elusive, we observe that surfactants with a critical micelle concentration of similar to 1 mM produce particles with the highest aspect ratio. A crystallographic analysis of nanorods obtained using gemini surfactants reveals that they grow along and are bound by {310} facets. This observation, which is specific for gemini surfactants, is explained by taking into account the preferential alignment of gemini surfactants with surface steps as suggested by electronic structure calculations.
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| 3. |
- Mellström, Dan, 1945, et al.
(författare)
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Older men with low serum estradiol and high serum SHBG have an increased risk of fractures
- 2008
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Ingår i: J Bone Miner Res. - : Wiley. - 1523-4681 .- 0884-0431. ; 23:10, s. 1552-60
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Tidskriftsartikel (refereegranskat)abstract
- Osteoporosis-related fractures constitute a major health concern not only in women but also in men. To study the predictive role of serum sex steroids for fracture risk in men, serum sex steroids were analyzed by the specific gas chromatography-mass spectrometry technique at baseline in older men (n = 2639; mean, 75 yr of age) of the prospective population-based MrOS Sweden cohort. Fractures occurring after baseline were validated (average follow-up of 3.3 yr). The incidence for having at least one validated fracture after baseline was 20.9/1000 person-years. Estradiol (E2; hazard ratio [HR] per SD decrease, 1.34; 95% CI, 1.22-1.49), free estradiol (fE2; HR per SD decrease, 1.41; 95% CI, 1.28-1.55), testosterone (T; HR per SD decrease, 1.27; 95% CI, 1.16-1.39), and free testosterone (fT; HR per SD decrease, 1.32; 95% CI, 1.21-1.44) were all inversely, whereas sex hormone-binding globulin (SHBG; HR per SD increase, 1.41; 95% CI, 1.22-1.63) was directly related to fracture risk. Multivariable proportional hazards regression models, adjusted for age, suggested that fE2 and SHBG (p
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| 4. |
- Uhr, Christian, et al.
(författare)
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Once upon a time in Västmanland : the power of narratives or how the “truth” unfolds
- 2016
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Ingår i: ISCRAM 2016 Conference Proceedings. - : ISCRAM. - 2411-3387. - 9788460879848
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Konferensbidrag (refereegranskat)abstract
- In 2014 a small fire started in a forest in central Sweden. Within a few days it developed into the largest wildfire in Sweden in the last 50 years. As the scale of the fire increased, so did the need for direction and coordination of the resources engaged in the response operation. Both official investigators and the research community have studied the challenges and come up with recommendations for improvements of the Swedish crisis management system. All authors of this paper have been involved in such efforts. This paper is a result of us trying to formulate lessons learnt based on several written reports and official discussions. The development of the narratives constructed by individuals involved in the response, investigators and researchers is analyzed. We conclude that researchers need to pay attention to their own role in this development. Maybe there is a need for a game changer on the methodological side?
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