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Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy : an international study of 264 real-world patients

Jakobsen, Lasse H. (author)
Aalborg University,Aalborg University Hospital,Aalborg Univ Hosp, Dept Hematol, Sdr Skovvej 15, DK-9000 Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway.
Ellin, Fredrik (author)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden.
Smeland, Knut B. (author)
Oslo university hospital,Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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Wästerlid, Tove (author)
Karolinska Institutet
Christensen, Jacob H. (author)
Odense University Hospital,Odense Univ Hosp, Dept Hematol, Odense, Denmark.
Jørgensen, Judit M. (author)
Aarhus University Hospital,Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark.,Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
Josefsson, Pär L. (author)
Herlev Hospital,Herlev Hosp, Dept Hematol, Herlev, Denmark.
Øvlisen, Andreas K. (author)
Aalborg University Hospital,Aalborg University,Aalborg Univ Hosp, Dept Hematol, Sdr Skovvej 15, DK-9000 Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
Holte, Harald (author)
Oslo university hospital,Roskilde Sygehus, Dept Hematol, Roskilde, Denmark.
Blaker, Yngvild N. (author)
Oslo university hospital,Oslo Univ Hosp, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway.;Oslo Univ Hosp, Inst Canc Res, Dept Canc Immunol, Oslo, Norway.
Grauslund, Jacob H. (author)
Zealand University Hospital
Bjørn, Jon (author)
Copenhagen University Hospital,Rigshosp, Dept Hematol, Copenhagen, Denmark.
Molin, Daniel, 1969- (author)
Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Uppsala Univ, Sweden
Lagerlöf, Ingemar (author)
Linköpings universitet,Linköping University,Linköping Univ, Dept Med & Hlth Sci, Div Drug Res, Linköping, Sweden.,Avdelningen för läkemedelsforskning,Medicinska fakulteten
Smedby, Karin E. (author)
Karolinska Institutet
Colvin, Katherine (author)
Sir Charles Gairdner Hospital,Sir Charles Gairdner Hosp, Dept Haematol, Nedlands, WA, Australia.
Thanarajasingam, Gita (author)
Mayo Clinic Minnesota,Mayo Clin, Div Hematol, Rochester, MN USA.
Maurer, Matthew J. (author)
Mayo Clinic Minnesota
Habermann, Thomas M. (author)
Mayo Clinic Minnesota,Mayo Clin, Div Hematol, Rochester, MN USA.
Song, Kevin W. (author)
BC Canc, Ctr Lymphoid Canc, Leukemia BMT Program BC, Vancouver, BC, Canada.
Zhu, Katie Y. (author)
BC Canc, Ctr Lymphoid Canc, Leukemia BMT Program BC, Vancouver, BC, Canada.
Gerrie, Alina S. (author)
BC Canc, Ctr Lymphoid Canc, Leukemia BMT Program BC, Vancouver, BC, Canada.
Cheah, Chan Y. (author)
University of Western Australia, Crawley,Sir Charles Gairdner Hospital,Sir Charles Gairdner Hosp, Dept Hematol, Nedlands, WA, Australia.;Pathwest Lab Med WA, Dept Hematol, Nedlands, WA, Australia.;Univ Western Australia, Med Sch, Crawley, Australia.
El-Galaly, Tarec C. (author)
Aalborg University,Aalborg University Hospital,Aalborg Univ Hosp, Dept Hematol, Sdr Skovvej 15, DK-9000 Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
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 (creator_code:org_t)
2020-02-04
2020
English 11 s.
In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 189:4, s. 661-671
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic-based and population-based lymphoma registries from six countries were used to identify 264 real-world patients. The median age was 47 years and the majority had advanced-stage disease and elevated LDH. Treatment protocols were R-CODOX-M/IVAC (47%), R-hyper-CVAD (16%), DA-EPOCH-R (11%), R-BFM/GMALL (25%) and other (2%) leading to an overall response rate of 89%. The two-year overall survival and event-free survival were 84% and 80% respectively. For patients in complete remission/unconfirmed, the two-year relapse risk was 6% but diminished to 0·6% for patients reaching 12 months of post-remission event-free survival (pEFS12). The loss of lifetime for pEFS12 patients was 0·4 (95% CI: −0·7 to 2) months. In conclusion, real-world outcomes of adult BL are excellent following intensive immunochemotherapy. For pEFS12 patients, the relapse risk was low and life expectancy similar to that of a general population, which is important information for developing meaningful follow-up strategies with increased focus on survivorship and less focus on routine disease surveillance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Keyword

Burkitt lymphoma
immunochemotherapy
prognosis
real-world patients
survival
Burkitt lymphoma

Publication and Content Type

art (subject category)
ref (subject category)

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