| 1. |
- Ameur, Adam, et al.
(författare)
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SweGen : a whole-genome data resource of genetic variability in a cross-section of the Swedish population
- 2017
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Ingår i: European Journal of Human Genetics. - : NATURE PUBLISHING GROUP. - 1018-4813 .- 1476-5438. ; 25:11, s. 1253-1260
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the SweGen data set, a comprehensive map of genetic variation in the Swedish population. These data represent a basic resource for clinical genetics laboratories as well as for sequencing-based association studies by providing information on genetic variant frequencies in a cohort that is well matched to national patient cohorts. To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide cohort of over 10 000 Swedish-born individuals included in the Swedish Twin Registry. A total of 1000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole-genome sequencing. Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a genome-wide collection of aggregated variant frequencies in the Swedish population that we have made available to the scientific community through the website https://swefreq.nbis.se. A total of 29.2 million single-nucleotide variants and 3.8 million indels were detected in the 1000 samples, with 9.9 million of these variants not present in current databases. Each sample contributed with an average of 7199 individual-specific variants. In addition, an average of 8645 larger structural variants (SVs) were detected per individual, and we demonstrate that the population frequencies of these SVs can be used for efficient filtering analyses. Finally, our results show that the genetic diversity within Sweden is substantial compared with the diversity among continental European populations, underscoring the relevance of establishing a local reference data set.
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| 2. |
- Axell, Cecilia
(författare)
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Barnlitteraturens tekniklandskap : En didaktisk vandring från Nils Holgersson till Pettson och Findus
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Syftet med denna studie är att utifrån ett didaktiskt perspektiv undersöka budskap om teknik i ett urval svenska skönlitterära barnböcker samt undersöka hur berättelsernas tekniksyner förhåller sig till deras natur- respektive framtidssyn. Analyserna grundar sig på sex svenska författares skönlitterära barnböcker: Selma Lagerlöf, Otto Witt, Elsa Beskow, Karl-Aage Schwartzkopf, Sven Wernström och Sven Nordqvist. Dessa böcker innehåller frågeställningar och problematiker som i dag anses betydelsefulla och relevanta inom teknikens didaktik. Studien har tre analytiska perspektiv: att identifiera tekniken som finns representerad i barnböckerna, att undersöka barnböckernas tekniksyner i förhållande till natur och framtid samt att finna gemensamma och särskiljande teman berättelserna emellan. Analyserna visar att de olika tekniksynerna i barnböckerna är mångfacetterade. Hur tekniken gestaltas kan delas in i sex övergripande teman: tekniken som metafor eller liknelse, som antropomorf, som autonom, som resultat av kreativ drivkraft, männens teknik samt som icke tidsbunden. Det förekommer också olika syn på teknik och dess inverkan på såväl individ som samhälle. Natursynen som dominerar kan beskrivas som svagt antropocentrisk och en majoritet av berättelserna förmedlar bilden av det effektiva framtidssamhället där tekniken löser människans problem. En slutsats är att barnlitteraturens tekniklandskap kan bidra till att både vidga och fördjupa det teknikdidaktiska perspektivet. Det ambivalenta budskapet i böckerna gör att teknikens mångskiftande natur lyfts fram samt problematiseras på ett sätt som läroböcker sällan gör. Skönlitterära barnböcker skulle därför kunna fungera som utgångspunkter för didaktiska diskussioner om teknikens natur samt dess inverkan på människa, samhälle och natur i såväl nutid som dåtid.
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| 3. |
- Axell, Cecilia, 1965-, et al.
(författare)
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Images of Technology and Sustainable Development in Swedish Children’s Literature
- 2014
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Ingår i: Australasian Journal of Technology Education. - : University of Waikato. ; 1:1, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this article is to investigate images of technology and how technology is linked to sustainable development in Swedish children’s literature. Our perspective is that such images represent values that are conveyed to the young generation. We have chosen to study books by four Swedish authors, Elsa Beskow, Inger Sandberg, Jan Lööf and Sven Nordqvist, all of them still read by many children, parents and teachers, both in and out of school. In the examined books, technology is portrayed in several modes: as a servant to man, as a deterministic force, as a loyal and equal companion to man, and as a natural phenomenon in a nostalgic world. Technologies that have a leading role in the stories examined are placed in different kind of contexts, more or less social, more or less utopian or idyllic. In all four authors’ writings there is an optimistic faith in children’s ability.
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| 4. |
- Axell, Cecilia, 1965-, et al.
(författare)
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Technology for a Sustainable Life. Images in Swedish Children’s Literature
- 2013
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Ingår i: PATT 27 Technology Education for the Future: A Playon Sustainability. - Hamilton, New Zealand. - 9780992249724 ; , s. 27-24
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Konferensbidrag (refereegranskat)abstract
- In the United Nations report Our common future sustainable development is defined as “development that meets the needs of the present without compromising the ability of future generations to meet their own needs”. Technology is seen as a kind of enabling force in that endeavour; new technologies are to be the solution to conflicts between growing economic activities and reductions in the use of natural resources. Sustainable development can, however, also be expressed as a set of traditional values that, in a country like Sweden, have been a part of everyday life for many generations. Education for sustainable development has been a goal in the Swedish national curriculum since 1994, not the least in the subject Technology. The teaching can evidently be inspired by both the international discussion on the future world and by the long tradition of how to live locally. The aim of this paper is to investigate images of technology and how technology is linked to sustainable development in children’s literature. Our perspective is that such images represent values that are conveyed to the young generation. We have chosen to study books by four Swedish authors, Elsa Beskow, Inger Sandberg, Jan Lööf and Sven Nordqvist, all of them still read by many children, parents and teachers alike, both in and out of school. Technology is in the examined books portrayed in several modes: as a servant to man, as a deterministic force, as a loyal and “equal” companion to man and as a natural phenomenon in a nostalgic world. Technologies that have a leading role in the examined stories are placed in different kind of contexts, more or less social, more or less utopian or idyllic. In all four author’s writings there is an optimistic faith in children’s ability to choose the right path. Children are the ones who must take responsibility for the future and overcome the problems the current adult generation have created. From a gender perspective, the message in the majority of the stories is clear: men are the source of technological development.
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| 5. |
- Bergman, Jonas, et al.
(författare)
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When the River Began—The Formation of River Motala Ström and Human Presence in the Early Holocene, Sweden
- 2020
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Ingår i: Quaternary. - : MDPI AG. - 2571-550X. ; 3:3
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Tidskriftsartikel (refereegranskat)abstract
- In conjunction with the extensive archaeological projects conducted at the current outlet of Sweden’s second largest lake, Lake Vättern, macrofossil, pollen and diatom records have been studied from 14C-dated lake and river sediments from River Motala Ström in Motala and Lake Boren. These investigations have revealed sedimentary evidence of the Yoldia Sea regression, the Ancient Lake Vättern transgression, and the following stepwise river formation process. Around 9000 cal BC, two small kettlehole basins at Strandvägen and Kanaljorden became isolated from the Baltic basin. As the ice sheet retreated further north, the isostatic uplift isolated the Vättern basin from the Baltic basin. Due to the uneven isostatic uplift, the basin tilted toward the south, and the Ancient Lake Vättern transgression started in Motala. The threshold in Motala at 92.5 m a.s.l. was reached around 7200 cal BC, and River Motala Ström was formed. 14C-dated diatom records from Lake Boren, and shoreline deposits in Motala, confirm this event. The water level in Lake Vättern initially fell around 1.5 m, and around 5800 cal BC, a second erosional event cut down the threshold to modern day level. At this time, the Late Mesolithic settlements in Motala were established and expanded.
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| 6. |
- Bergström, Göran, et al.
(författare)
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Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis : The Swedish CardioPulmonary BioImage Study
- 2024
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Ingår i: Journal of the American Heart Association. - : American Heart Association. - 2047-9980. ; 13:14
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis. METHODS AND RESULTS: We used data from the population-based SCAPIS (Swedish CardioPulmonary BioImage Study) in individuals with coronary computed tomography angiography (n=25 182) and coronary artery calcification score (n=28 701), aged 50 to 64 years without previous ischemic heart disease. We developed a risk prediction tool using variables that could be assessed from home (self-report tool). For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self-report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. The self-report tool (n=14 variables) and the clinical tool (n=23 variables) showed high-to-excellent discriminative ability to identify a segment involvement score ≥4 (area under the curve 0.79 and 0.80, respectively) and significantly better than the pooled cohort equation (area under the curve 0.76, P<0.001). The tools showed a larger net benefit in clinical decision-making at relevant threshold probabilities. The self-report tool identified 65% of all individuals with a segment involvement score ≥4 in the top 30% of the highest-risk individuals. Tools developed for coronary artery calcification score ≥100 performed similarly. CONCLUSIONS: We have developed a self-report tool that effectively identifies individuals with moderate to severe coronary atherosclerosis. The self-report tool may serve as prescreening tool toward a cost-effective computed tomography-based screening program for high-risk individuals.
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| 7. |
- Beskow, Jonas, et al.
(författare)
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Expressive robot performance based on facial motion capture
- 2021
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Ingår i: Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH. - : International Speech Communication Association. ; , s. 2165-2166, s. 2343-2344
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Konferensbidrag (refereegranskat)abstract
- The Furhat robot is a social robot that uses facial projection technology to achieve a high degree of expressivity and flexibility. In this demonstration, we will present new features that takes this facial expressiveness further. A new face engine for the robot is presented which not only drastically improves the visual fidelity of the face and the eyes, it also adds increased flexibility when it comes to designing new robotic characters as well as modifying existing ones. Most importantly, we will present a new toolset and a workflow that allows users to record their own face motion and incorporate them into skills (i.e. custom robot applications) as gestures, prompts or entire canned performances.
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| 8. |
- Elmqvist, Niklas, 1977, et al.
(författare)
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3DVN: A Mixed Reality Platform for Mobile Navigation Assistance
- 2006
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We present 3DVN, a Mixed Reality platform for navigation assistance in indoor environments. Built on top of a PC-based wearable computer running the Windows operating system, the platform provides a multimodal user interface for navigating in existing physical buildings, including wireless networking, data glove gestural input, voice communication, head-mounted display, and a 3DOF head tracker. Local positioning is performed using a software-only positioning engine making use of WLAN features for accurately pinpointing the mobile device in three dimensions. The 3DVN system has been implemented as a proof-of-concept of a navigation guidance support device for visitors, and has been field-tested with human subjects in the student center of our university. Informal evaluation of subject ratings indicate a strong interest for the new system, both for guests as well as people familiar with the campus and the building.
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| 9. |
- Elmqvist, Niklas, 1977, et al.
(författare)
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3DVN: A Mixed Reality Platform for Mobile Navigation Assistance
- 2007
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Ingår i: ACM CHI2007 Workshop on Mobile Spatial Interaction. ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- We present 3DVN, a Mixed Reality platform for navigation assistance in indoor environments. Built on top of a PC-based wearable computer running the Windows operating system, the platform provides a multimodal user interface to navigate existing physical buildings, including wireless networking, data glove gestural input, voice communication, head-mounted display, and a 3DOF head tracker. Local positioning is performed using a software-only WLAN-based engine to accurately pinpoint the mobile device in three dimensions. We use this system as a platform for a simple theoretical framework for classifying interaction for mobile navigation assistance. Informal qualitative evaluation of our system seems to conform to predictions derived from our framework and shows the need for a rich set of interaction components for successful mobile navigation.
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| 10. |
- Enger, Jonas, 1966, et al.
(författare)
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Optical tweezers applied to a microfluidic system
- 2004
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Ingår i: Lab on a Chip. - : Royal Society of Chemistry (RSC). - 1473-0197 .- 1473-0189. ; 4, s. 196-200
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Tidskriftsartikel (refereegranskat)abstract
- We will demonstrate how optical tweezers can be combined with a microfluidic system to create a versatile microlaboratory. Cells are moved between reservoirs filled with different media by means of optical tweezers. We show that the cells, on a timescale of a few seconds, can be moved from one reservoir to another without the media being dragged along with them. The system is demonstrated with an experiment where we expose E. coli bacteria to different fluorescent markers. We will also discuss how the system can be used as an advanced cell sorter. It can favorably be used to sort out a small fraction of cells from a large population, in particular when advanced microscopic techniques are required to distinguish various cells. Patterns of channels and reservoirs were generated in a computer and transferred to a mask using either a sophisticated electron beam technique or a standard laser printer. Lithographic methods were applied to create microchannels in rubber silicon (PDMS). Media were transported in the channels using electroosmotic flow. The optical system consisted of a combined confocal and epi-fluorescence microscope, dual optical tweezers and a laser scalpel.
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