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Search: WFRF:(Hakeberg Magnus 1954 ) > (2005) > Journal article > Bratel John 1953 > The effect of Longo...

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The effect of LongoVital on recurrent aphthous stomatitis in a controlled clinical trial.

Bratel, John, 1953 (author)
Gothenburg University,Göteborgs universitet,Odontologiska institutionen,Institute of Odontology
Hakeberg, Magnus, 1954 (author)
Jönköping University,Gothenburg University,Göteborgs universitet,Odontologiska institutionen,Institute of Odontology,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Centrum för oral hälsa
Jontell, Mats, 1951 (author)
Gothenburg University,Göteborgs universitet,Odontologiska institutionen,Institute of Odontology
 (creator_code:org_t)
2005
2005
English.
In: Oral health & preventive dentistry. - 1602-1622. ; 3:1, s. 3-8
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • PURPOSE: The aim of this study was to evaluate the effect of daily intake of LongoVital (LV) (herbal vitamin tablets) in the prevention of RAS. MATERIALS AND METHODS: A group of 78 consecutively referred patients was enrolled to a three-months pretreatment period. Fifty subjects were then randomly allocated to an LV-group (n = 25) or a placebo group (N = 25). A double blind, stratified-randomised clinical case-control study was performed during six months. Number and size of the ulcers were registered by the patients using a standardized chart. The degree of discomfort was recorded on a 100 mm horizontal visual analogue scale (VAS-scale). RESULTS: The three-months pretreatment period revealed that the most dominant symptoms were pain (78%) followed by burning sensation (18%). No significant differences between the two groups were found during this period when a comparison was made at the end of the study. After the intervention period the number of aphthous ulcers/month decreased significantly in the LV-group (p = 0.02). The number of days in pain/month were also reduced (p < 0.001). If a 50% reduction of number of aphthous ulcers and days in pain were considered as clinically relevant, no statistical significant differences were found between the groups. CONCLUSION: Thus, no strong evidence was found that justified a recommendation of LV as a general drug for treatment of RAS.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Keyword

Adult
Aged
Double-Blind Method
Drug Combinations
Female
Humans
Male
Middle Aged
Phytotherapy
Plant Components
Plant Preparations
therapeutic use
Plants
Medicinal
Recurrence
prevention & control
Statistics
Nonparametric
Stomatitis
Aphthous
prevention & control
Tablets
Vitamins
therapeutic use
Adult

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ref (subject category)
art (subject category)

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Bratel, John, 19 ...
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Oral health & pr ...
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University of Gothenburg
Jönköping University

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