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1.
  • Beecham, Ashley H., et al. (författare)
  • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
  • 2013
  • Ingår i: Nature Genetics. - NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA. - 1061-4036. ; 45:11, s. 1353-
  • Tidskriftsartikel (refereegranskat)abstract
    • Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P andlt; 1.0 x 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P andlt; 5.0 x 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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2.
  • Locke, Adam E, et al. (författare)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 518:7538, s. 197-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
3.
  • Wood, Andrew R, et al. (författare)
  • Defining the role of common variation in the genomic and biological architecture of adult human height
  • 2014
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 46:11, s. 1173-1186
  • Tidskriftsartikel (refereegranskat)abstract
    • Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
4.
  • Abazov, V. M., et al. (författare)
  • A combined search for the standard model Higgs boson at root S=1.96 TeV
  • 2008
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 663:1-2, s. 26-36
  • Tidskriftsartikel (refereegranskat)abstract
    • We present new results of the search for WH --&gt; lvb (b) over bar production in p (p) over bar collisions at a center-of-mass energy of root S = 1.96 TeV, based on a dataset with integrated luminosity of 0.44 fb(-1). We combine these new results with previously published searches by the DO collaboration, for WH and ZH production analyzed in the E(T)b (b) over bar final state, for ZH (--&gt; l(+)l(-)b (b) over bar) production, for WH (--&gt;. WWW) production, and for H (--&gt; W W) direct production. No signal-like excess is observed either in the W H analysis or in the combination of all D0 Higgs boson analyses. We set 95% C.L. (expected) upper limits on sigma(p (p) over bar --&gt; WH) x B(H --&gt; b (b) over bar) ranging from 1.6 (2.2) ph to 1.9 (3.3) pb for Higgs boson masses between 105 and 145 GeV, to be compared to the theoretical prediction of 0.13 pb for a Standard Model (SM) Higgs boson with mass in m(H) = 115 GeV. After combination with the other DO Higgs boson searches, we obtain for in H = 115 GeV an observed (expected) limit 8.5 (12.1) times higher than the SM predicted Higgs boson production cross section. For m(H) = 160 GeV, the corresponding observed (expected) ratio is 10.2 (9.0).
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5.
  • Abazov, V. M., et al. (författare)
  • Combined D0 measurements constraining the CP-violating phase and width difference in the B-s(0) system
  • 2007
  • Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 76:5, s. 057101
  • Tidskriftsartikel (refereegranskat)abstract
    • We combine the D0 measurement of the width difference between the light and heavy B-s(0) mass eigenstates and of the CP-violating mixing phase determined from the time-dependent angular distributions in the B-s(0)-&gt; J/psi phi decays along with the charge asymmetry in semileptonic decays also measured with the D0 detector. With the additional constraint from the world average of the flavor-specific B-s(0) lifetime, we obtain Delta Gamma(s)equivalent to(Gamma(L)-Gamma(H))=0.13 +/- 0.09 ps(-1) and vertical bar phi(s)vertical bar=0.70(-0.47)(+0.39) or Delta Gamma(s)=-0.13 +/- 0.09 ps(-1) and vertical bar phi(s)vertical bar=2.44(-0.39)(+0.47). The data sample corresponds to an integrated luminosity of 1.1 fb(-1) accumulated with the D0 detector at the Fermilab Tevatron Collider.
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6.
  • Abazov, V. M., et al. (författare)
  • Direct observation of the strange b baryon Xi(-)(b)
  • 2007
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 99:5, s. 052001
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the first direct observation of the strange b baryon Xi(-)(b)(Xi) over bar (+)(b)). We reconstruct the decay Xi(-)(b)--&gt;J/psi Xi(-), with J/psi--&gt;mu(+)mu(-), and Xi(-)--&gt;Lambda pi(-)--&gt;p pi(-)pi(-) in p (p) over bar collisions at root s = 1.96 TeV. Using 1.3 fb(-1) of data collected by the D0 detector, we observe 15.2 +/- 4.4(stat)(-0.4)(+1.9)(syst) Xi(-)(b) candidates at a mass of 5.774 +/- 0.011(stat) +/- 0.015(syst) GeV. The significance of the observed signal is 5.5 sigma, equivalent to a probability of 3.3 x 10(-8) of it arising from a background fluctuation. Normalizing to the decay Lambda(b)--&gt;J/psi Lambda, we measure the relative rate sigma(Xi(-)(b))xB(Xi(-)(b)--&gt;J/psi Xi)/ sigma(Lambda(b))xB(Lambda(b)--&gt;J/psi Lambda) = 0.28 +/- 0.09(stat)(-0.08)(+0.09)(syst).
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7.
  • Abazov, V. M., et al. (författare)
  • Evidence for production of single top quarks and first direct measurement of vertical bar V-tb vertical bar
  • 2007
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:18, s. 181802
  • Tidskriftsartikel (refereegranskat)abstract
    • The D0 Collaboration presents first evidence for the production of single top quarks at the Fermilab Tevatron &lt; p(p)over bar &gt; collider. Using a 0.9 fb(-1) dataset, we apply a multivariate analysis to separate signal from background and measure sigma(&lt; p(p)over bar &gt;-&gt; tb+X,tqb+X)=4.9 +/- 1.4 pb. The probability to measure a cross section at this value or higher in the absence of a signal is 0.035%, corresponding to a 3.4 standard deviation significance. We use the cross section measurement to directly determine the Cabibbo-Kobayashi-Maskawa matrix element that describes the Wtb coupling and find 0.68 &lt;= 1 at 95% C.L. within the standard model.
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8.
  • Abazov, V. M., et al. (författare)
  • Experimental discrimination between charge 2e/3 top quark and charge 4e/3 exotic quark production scenarios
  • 2007
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:4, s. 041801
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the first experimental discrimination between the 2e/3 and 4e/3 top quark electric charge scenarios, using top quark pairs (t (t) over bar) produced in p (p) over bar collisions at root s =1.96 TeV by the Fermilab Tevatron Collider. We use 370 pb(-1) of data collected by the D0 experiment and select events with at least one high transverse momentum electron or muon, high transverse energy imbalance, and four or more jets. We discriminate between b- and (b) over bar -quark jets by using the charge and momenta of tracks within the jet cones. The data are consistent with the expected electric charge, |q|=2e/3. We exclude, at the 92% C.L., that the sample is solely due to the production of exotic quark pairs Q (Q) over bar with |q|=4e/3. We place an upper limit on the fraction of Q (Q) over bar pairs rho &lt; 0.80 at the 90% C.L.
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9.
  • Abazov, V. M., et al. (författare)
  • Lifetime difference and CP-violating phase in the B-s(0) system
  • 2007
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:12, s. 121801
  • Tidskriftsartikel (refereegranskat)abstract
    • From an analysis of the decay B-s(0)-&gt; J/psi phi, we obtain the width difference between the light and heavy mass eigenstates Delta Gamma equivalent to(Gamma(L)-Gamma(H))=0.17 +/- 0.09(stat)+/- 0.02(syst) ps(-1) and the CP-violating phase phi(s)=-0.79 +/- 0.56(stat)(-0.01)(+0.14)(syst). Under the hypothesis of no CP violation (phi(s)equivalent to 0), we obtain 1/Gamma=tau/(B-s(0))=1.52 +/- 0.08(stat)(-0.03)(+0.01)(syst) ps and Delta Gamma=0.12(-0.10)(+0.08)(stat)+/- 0.02(syst) ps(-1). The data sample corresponds to an integrated luminosity of about 1.1 fb(-1) accumulated with the D0 detector at the Fermilab Tevatron collider. This is the first direct measurement of the CP-violating mixing phase in the B-s(0) system.
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10.
  • Abazov, V. M., et al. (författare)
  • Measurement of B-d mixing using opposite-side flavor tagging
  • 2006
  • Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 74:11, s. 112002
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on a measurement of the B-d(0) mixing frequency and the calibration of an opposite-side flavor tagger in the D0 experiment. Various properties associated with the b quark on the opposite side of the reconstructed B meson are combined using a likelihood-ratio method into a single variable with enhanced tagging power. Its performance is tested with data, using a large sample of reconstructed semileptonic B -&gt;mu(DX)-X-0 and B -&gt;mu(DX)-X-* decays, corresponding to an integrated luminosity of approximately 1 fb(-1). The events are divided into groups depending on the value of the combined tagging variable, and an independent analysis is performed in each group. Combining the results of these analyses, the overall effective tagging power is found to be epsilon D-2=(2.48 +/- 0.21(-0.06)(+0.08))%. The measured B-d(0) mixing frequency Delta m(d)=0.506 +/- 0.020(stat)+/- 0.016(syst) ps(-1) is in good agreement with the world average value.
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