| 1. |
- Halldin, Sven, et al.
(författare)
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NOPEX - a northern hemisphere climate processes land surface experiment
- 1998
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Ingår i: Journal of Hydrology. - 0022-1694 .- 1879-2707. ; 212-213, s. 172-187
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Tidskriftsartikel (refereegranskat)abstract
- The interface between land surfaces and the atmosphere is a key area in climate research, where lack of basic knowledge prevents us from reducing the considerable uncertainties about predicted changes. Boreal forests play an important, but not well known, role in the global hydrological and biogeochemical cycles. NOPEX (a NOrthern hemisphere climate Processes land surface EXperiment) is devoted to the study of land surface-atmosphere interaction in a northern European forest-dominated landscape. The main NOPEX region represents the southern edge of the boreal zone. It consists of a highly heterogeneous landscape, with forests, mires, agricultural land and lakes. A second study site, in northern Finland, representing the northern edge of the boreal zone, will be introduced into NOPEX in connection with its coming winter-time field activities. Field activities, dominating the initial phase of NOPEX, are conceived to strike a balance between the need to cover multi-annual observations and the resources required to carry out measurements covering all relevant spatial scales. The long-term data collection activities, the Continuous Climate Monitoring (CCM), form the backbone of the field programme. A suite of Concentrated Field Efforts (CFEs) covering periods of summer, spring and winter brings together scientists from more then 20 countries during month-long campaigns. CFEs have been carried out in May-June 1994 and April-July 1995. A third, winter-time CFE is planned for 1998-99. The System for Information in NOPEX (SINOP) is the database which forms a backbone for modelling and analysis work, dominating the second stage of NOPEX. A series of PhD courses are run in parallell to the research activities. Analysis and modelling are done in four interacting areas, including local-scale processes, meso-scale surface-atmosphere coupling and remote sensing techniques. The fourth area, regionalization methods, aims at bringing the previous three together in order to provide improved parameterization schemes for exchange of energy, momentum, water and CO2 between land and atmosphere in hydrological and meteorological models from the meso to the global scale.
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| 2. |
- Bockgård, Niclas, 1974-
(författare)
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Groundwater Recharge in Crystalline Bedrock : Processes, Estimation, and Modelling
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Kunskap om grundvattenbildningen är nödvändig för att man ska kunna förutsäga konsekvenserna av grundvattenuttag och underjordsbyggande. Grundvattenbildningen i berggrunden är dock svår att uppskatta. Syftet med avhandlingen var att öka förståelsen av grundvattenbildningen i kristallin berggrund, att undersöka hur grundvattenbildningen ska uppskattas samt att utveckla nya modeller för att beskriva grundvattenbildningen. Studien grundades på tre angreppssätt: grundvattendatering med freoner (CFC), geohydrauliska observationer och matematisk modellering.Koncentrationerna av CFC-11 och CFC-113 befanns vara låga i det undersökta berggrundvattnet, vilket i kombination med låga syrgashalter tyder på anaerob nedbrytning. Koncentrationerna av CFC-12 och tritium överensstämde ganska väl, vilket betyder att den skenbara åldern kan vara den sanna åldern. Resultaten tyder på att CFC-datering inte är pålitlig i skogsmiljöer med finkornigt jordtäcke.Vid nederbörd observerades ett snabbt gensvar i den hydrauliska potentialen i den studerade bergakviferen, trots det 10 m mäktiga moräntäcket. En avsevärd del av de observerade potentialvariationerna befanns vara belastningseffekter, som inte innebar någon magasinsförändring eller något vattenflöde. Berggrundens belastningseffektivitet uppskattades, ur potentialens svar på lufttrycksförändringar, till 0,95. Ytbelastningen beräknades från mätningar av lufttryck, vatten i jordtäcket och snö. Omkring 20 % av årstidsvariationen hos den hydrauliska potentialen uppskattades bero på enbart belastningsförändringar. En enkel begreppsmässig modell kunde användas för att simulera den observerade hydrauliska potentialen. För att beskriva enskilda grundvattenbildningstillfällen på bästa sätt var det nödvändigt att ta hänsyn till effekten av ytbelastningen.Numeriska experiment gjordes med en modell av en jord–bergprofil. När berget modellerades som ett heterogent kontinuum bildades omättade zoner i berget vid stora hydrauliska gradienter. Fenomenet uppträdde i områden där låggenomsläppliga zoner låg uppströms höggenomsläppliga zoner, och ledde till minskad hydraulisk konduktivitet i berget.
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| 3. |
- Braniste, Viorica, et al.
(författare)
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The gut microbiota influences blood-brain barrier permeability in mice
- 2014
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science. - 1946-6234 .- 1946-6242. ; 6:263, s. 263ra158-
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Tidskriftsartikel (refereegranskat)abstract
- Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota-BBB communication is initiated during gestation and propagated throughout life.
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| 4. |
- Carlson, Karin, et al.
(författare)
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Language policy for a bilingual faculty
- 2005
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Ingår i: Bi- and multilingual universities, Helsinki, Finland, Sept 1-3, 2005.
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Konferensbidrag (refereegranskat)abstract
- The Faculty of Science and Technology of Uppsala University is for all practical purposes a bilingual institution, using both Swedish and English in education and research. Extensive use of English in teaching, and also in intrauniversity communication, permits recruitment of nonSwedishspeaking students, researchers and professors, and also prepares our students forinternational careers. However, the introduction of English has been somewhat haphazard, not taking into account possible negative effects on communication in Swedish, nor on students'learning.In order to improve students' and professors' language skills, and achieve a good balance between Swedish and English, the faculty board appointed a language committee in 2003 whose task was to propose a language policy for the faculty. A first part, stating as a main goal that all communication from and within the faculty should have the highest quality possible, has been adopted by the board. A second part including language planning with respect to status, corpus, and acquisition for both Swedish and English to accomplish this goal was sent to the board of the faculty in May, 2005. Implementation of this policy will affect all faculty activities, especially education. Suggestedannual reports on language status will raise our present minimal knowledge about possible domain losses and allow for relevant countermeasures.
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| 5. |
- Cervenka, Simon, et al.
(författare)
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Support for dopaminergic hypoactivity in restless legs syndrome : a PET study on D2-receptor binding
- 2006
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Ingår i: Brain. - Karolinska Univ Hosp Solna, Dept Clin Neurosci, Psychol Sect, Karolinska Inst, SE-17176 Stockholm, Sweden. Karolinska Univ Hosp Huddinge, Div Clin Pharmacol, Dept Lab Med, Stockholm, Sweden. Karolinska Univ Hosp Huddinge, Dept Neurol, Stockholm, Sweden. GlaxoSmithKline Inc, Translat Med & Genet, Cambridge, England. Univ Manchester, Wolfson Mol Imaging Ctr, Manchester, Lancs, England. GlaxoSmithKline Inc, Neurol Discovery Med, Harlow, Essex, England. : OXFORD UNIV PRESS. - 0006-8950 .- 1460-2156. ; 129, s. 2017-2028
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Tidskriftsartikel (refereegranskat)abstract
- Clinical observations support a central role of the dopamine system in restless legs syndrome (RLS) but previous imaging studies of striatal dopamine D2-receptors have yielded inconclusive results. Extrastriatal dopaminergic function has hitherto not been investigated. Sixteen RLS patients naive to dopaminergic drugs and sixteen matched control subjects were examined with PET. [C-11]Raclopride and [C-11]FLB 457 were used to estimate D2-receptor availability in striatum and extrastriatal regions, respectively. Examinations were performed both in the morning (starting between 10:00 and 12:00 h) and evening (starting at 18:00 h). Measures were taken to monitor and control for head movement during data acquisition. In the striatum, patients had significantly higher [C-11]raclopride binding potential (BP) values than controls. In extrastriatal regions, [C-11]FLB 457 BP was higher in patients than controls, and in the regional analysis the difference was statistically significant in subregions of thalamus and the anterior cingulate cortex. The diurnal variability in BP with [C-11]FLB 457 and [C-11]raclopride was within the previously reported test-retest reproducibility for both radioligands. The study supports involvement of the dopamine system in both striatal and extrastriatal brain regions in the pathophysiology of RLS. The brain regions where differences in D2-receptor binding were shown are implicated in the regulation of affective and motivational aspects of sensory processing, suggesting a possible pathway for sensory symptoms in RLS. Increased D2-receptor availability in RLS may correspond to higher receptor densities or lower levels of endogenous dopamine. Both interpretations are consistent with the hypothesis of hypoactive dopaminergic neurotransmission in RLS, as increased receptor levels can be owing to receptor upregulation in response to low levels of endogenous dopamine. The results do not support variations in dopamine D2-receptor availability as a correlate to the diurnal rhythm of RLS symptoms.
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| 6. |
- Chen, D., et al.
(författare)
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A high-resolution, gridded dataset for monthly temperature normals (1971 – 2000) in Sweden
- 2007
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Ingår i: Geografiska Annaler. Series A, Physical Geography. - : Informa UK Limited. - 0435-3676 .- 1468-0459. ; 89:4, s. 249-261
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Tidskriftsartikel (refereegranskat)abstract
- A baseline climatology is required in evaluating climate variability and changes on regional and local scales. Gridded climate normals, i.e. averages over a 30-year period, are of special interest since they can be readily used for validation of climate models. This study is aimed at creating an updated gridded dataset for Swedish monthly temperature normals over the period 1971–2000, based on standard 2-m air temperature records at 510 stations in mainland Sweden. Spatial trends of the normal temperatures were modelled as functions of latitude, longitude and elevation by multiple linear regression. The study shows that the temperature normals are strongly correlated with latitude throughout the year and especially in cold months, while elevation was a more important factor in June and July. Longitude played a minor role and was only significant in April and May. Regression equations linking temperature to latitude, longitude and elevation were set up for each month. Monthly temperature normals were detrended by subtracting spatial trends given by the regressions. Ordinary kriging was then applied to both original data (simple method) and de-trended data (composite method) to model the spatial variability and to perform spatial gridding. The multiple regressions showed that between 82% (summer) and 96% (winter) of the variance in monthly temperature normals could be explained by latitude and elevation. Unexplained variances, i.e. the residuals, were modelled with ordinary kriging with exponential semivariograms. The composite grid estimates were calculated by adding the multiple linear trends back to the interpolated residuals at each grid point. Kriged original temperature normals provided a performance benchmark. The cross–validation shows that the interpolation errors of the normals are significantly reduced if the composite method rather than the simple one was used. A gridded monthly dataset with 30-arcsecond spacing was created using the established trends, the kriging model and a digital topographic dataset.
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| 7. |
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| 8. |
- Comley, Robert A., et al.
(författare)
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A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel-Based Morphometry
- 2012
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Ingår i: Journal of Neuroimaging. - : WILEY-BLACKWELL. - 1051-2284 .- 1552-6569. ; 22:1, s. 28-32
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls, using voxel-based morphometry (VBM). All 4 studies have provided different results. METHODS Optimized VBM was used to search for structural differences in gray matter density. Sixteen RLS patients naive to dopaminergic drugs and 16 age-and sex-matched controls received structural T1-weighted MR scans. Structural data were analyzed using FSL-VBM. RESULTS No difference in gray matter density was detected between the two groups (voxel-wise significance: no significant voxels at P = .89 (whole brain Family Wise Error (FWE) corrected); no significant voxels at P < .05 (whole brain False Discovery Rate (FDR) corrected; smallest achievable FDR threshold .99). CONCLUSION/DISCUSSION The present study did not replicate (confirm) previous findings of structural brain changes in RLS, but instead supported the findings of a recent study showing a lack of gray matter alteration in an elderly RLS population. More specifically, the results do not support neuronal loss as an underlying disease mechanism in RLS. Potential limitations in the application of VBM are also discussed.
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