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1.
  • Bevilacqua, Riccardo, 1974-, et al. (creator_code:aut_t)
  • Medley spectrometer for light ions in neutron-induced reactions at 175 MeV
  • 2011
  • record:In_t: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 646:1, s. 100-107
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • We have upgraded the Medley spectrometer to measure neutron-induced double differential cross-sections for light-ion production, with neutron energies up to 175 MeV. Measurements were performed at the quasi-monoenergetic neutron beam line at the The Svedberg Laboratory, in Uppsala (Sweden). Medley is a spectrometer system composed of eight three-element telescope detectors; Delta E-E technique is used for particle identification and total kinetic energy measurement. We have improved particle separation and installed new detectors that fully stop ions with kinetic energy up to 170 MeV. To reduce the contribution of the low energy tail in the quasi-monoenergetic neutron spectrum, we have applied time-of-flight techniques and investigated the results for measurements with 175 MeV neutrons. We have investigated the response function of the CsI(Tl) scintillators and describe a method for efficiency correction. We have studied the signal-to-background ratio of the new configuration of the spectrometer and of the collimation system. A method to obtain absolute cross-section normalization, separating the peak neutrons from the low-energy tail, is proposed. Finally we have characterized the 175 MeV quasi-monoenergetic neutron spectrum with the Medley spectrometer. This upgraded configuration has been used in 2007 and 2009 for light-ion production measurements at 175 MeV from C, Si, O, Fe, Bi and U.
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2.
  • Neuwirth, Christoph, et al. (creator_code:aut_t)
  • Implementing Motor Unit Number Index (MUNIX) in a large clinical trial : Real world experience from 27 centres
  • 2018
  • record:In_t: Clinical Neurophysiology. - : Elsevier. - 1388-2457 .- 1872-8952. ; 129:8, s. 1756-1762
  • swepub:Mat_article_t (swepub:level_refereed_t)abstract
    • OBJECTIVE: Motor Unit Number Index (MUNIX) is a quantitative neurophysiological method that reflects loss of motor neurons in Amyotrophic Lateral Sclerosis (ALS) in longitudinal studies. It has been utilized in one natural history ALS study and one drug trial (Biogen USA) after training and qualification of raters.METHODS: Prior to testing patients, evaluators had to submit test-retest data of 4 healthy volunteers. Twenty-seven centres with 36 raters measured MUNIX in 4 sets of 6 different muscles twice. Coefficient of variation of all measurements had to be <20% to pass the qualification process. MUNIX COV of the first attempt, number of repeated measurements and muscle specific COV were evaluated.RESULTS: COV varied considerably between raters. Mean COV of all raters at the first measurements was 12.9% ± 13.5 (median 8.7%). Need of repetitions ranged from 0 to 43 (mean 10.7 ± 9.1, median 8). Biceps and first dorsal interosseus muscles showed highest repetition rates. MUNIX variability correlated considerably with variability of compound muscle action potential.CONCLUSION: MUNIX revealed generally good reliability, but was rater dependent and ongoing support for raters was needed.SIGNIFICANCE: MUNIX can be implemented in large clinical trials as an outcome measure after training and a qualification process.
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