| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 3. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 4. |
- Eladawy, A., et al.
(författare)
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Characterization of the northern Red Sea's oceanic features with remote sensing data and outputs from a global circulation model
- 2017
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Ingår i: Oceanologia. - : Elsevier BV. - 0078-3234. ; 59:3, s. 213-237
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Tidskriftsartikel (refereegranskat)abstract
- Sea surface temperature (SST) and surface wind ( SW) are considered the most important components in air-sea interactions. This study examines the relationships between SST, SW and various oceanic variables in the northern Red Sea (NRS) during the period of 2000-2014. The current study is the first attempt to identify the SST fronts and their relationship with the dominant circulation patterns. SST fronts are mapped using the Cayula and Cornillon algorithms. The analysis is performed with available remote sensing and reanalyzed data together with 1/12 degrees HYbrid Coordinate Ocean Model (HYCOM) outputs. Seasonal-trend decomposition procedure based on loess (STL) is applied for trend analysis, and Principal Component Analysis (PCA) is run for the atmospheric parameters. The SST, SW speed and Chlorophyll-a (Chl-a) changes show insignificant trends during the period of 2000-2014. Meridional SST fronts are more significant during the month of January, and fronts that are perpendicular to the sea's axis occur from February to May. Distinct monthly and spatial variations are present in all the examined parameters, although these variations are less pronounced for the wind direction. The SST is mainly controlled by the air temperature and sea level pressure. Significant correlations exist between the SST and the studied parameters (alongshore wind stress rather than the cross-shore wind stress, surface circulation, MLD, and Chl-a). Surface winds generally flow southeastward parallel to the Red Sea's axis explaining that alongshore wind stress is highly correlated with the studied parameters. (C) 2017 Institute of Oceanology of the Polish Academy of Sciences. Production and hosting by Elsevier Sp. z o. o.
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| 5. |
- Hedblom, Andreas, et al.
(författare)
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Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury
- 2019
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Ingår i: Cell Death and Disease. - : Nature Publishing Group. - 2041-4889 .- 2041-4889. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Phenotypic changes of myeloid cells are critical to the regulation of premature aging, development of cancer, and responses to infection. Heme metabolism has a fundamental role in the regulation of myeloid cell function and activity. Here, we show that deletion of heme oxygenase-1 (HO-1), an enzyme that removes heme, results in an impaired DNA damage response (DDR), reduced cell proliferation, and increased cellular senescence. We detected increased levels of p16INK4a, H2AXγ, and senescence-associated-β-galactosidase (SA-β-Gal) in cells and tissues isolated from HO-1-deficient mice. Importantly, deficiency of HO-1 in residential macrophages in chimeric mice results in elevated DNA damage and senescence upon radiation-induced injury. Mechanistically, we found that mammalian target of rapamycin (mTOR)/S6 protein signaling is critical for heme and HO-1-regulated phenotype of macrophages. Collectively, our data indicate that HO-1, by detoxifying heme, blocks p16INK4a expression in macrophages, preventing DNA damage and cellular senescence.
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| 6. |
- Johannesson, Liza, 1976, et al.
(författare)
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Uterus transplantation in a non-human primate: long-term follow-up after autologous transplantation.
- 2012
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Ingår i: Human reproduction (Oxford, England). - : Oxford University Press (OUP). - 1460-2350 .- 0268-1161. ; 27:6, s. 1640-8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Uterus transplantation (UTx) may provide the first available treatment for women affected by uterine infertility. The present study aimed to further develop a surgical technique for autologous UTx in a non-human primate species and to assess long-term function. METHODS Female baboons (n= 16) underwent autologous transplantation of the uterus with the Fallopian tubes and ovaries, performed with a previously published surgical technique (n= 6, Group 1) or using a modified technique (n= 10; Group 2). The uterine arteries were dissected to the proximal end of the anterior branch (Group 1) or the entire (Group 2) internal iliac artery, and the ovarian veins were dissected to the crossing over the ureter (Group 1) or further cranially to include greater lengths and patches of the cava/renal vein (Group 2). Back-table preparation created common venous and arterial ends with arterial anastomosis either end-to-side to the left external iliac artery (Group 1) or end-to-end to the left internal iliac artery (Group 2). RESULTS Overall short-time survival of the animals was 88% (66% in Group 1 and 100% in Group 2). Of all the operated animals, 75% (66% in Group 1 and 80% in Group 2) resumed ovarian cyclicity. Regular menstruation after UTx was demonstrated only in Group 2 (60%). Menstruating animals (n= 6) were each exposed to timed mating for ≥5 menstrual cycles, but pregnancy did not occur. Adhesions and tubal blockage were seen in post-mortem analysis. CONCLUSIONS The modified UTx model of Group 2 is a safe procedure and shows resumed long-term uterine function in a majority of the animals, although pregnancy could not be demonstrated.
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| 7. |
- Racho El-Akouri, Randa, 1971, et al.
(författare)
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Uterus transplantation: An update and the Middle East perspective
- 2017
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Ingår i: Middle East Fertility Society Journal. - : Springer Science and Business Media LLC. - 1110-5690. ; 22:3, s. 163-169
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Tidskriftsartikel (refereegranskat)abstract
- Uterus transplantation (UTx) is the only available treatment for absolute uterine factor infertility (AUFI), which is caused by either absence (congenital or after hysterectomy) or presence of a non-functioning uterus. Uterus transplantation became a clinical reality after more than 10 years of structured animal-based research. Aside from gestational surrogacy, this procedure is the only alternative for women with AUFI to attain genetic motherhood. In the Middle East, North Africa and Turkey (MENAT) region, out of a population of around 470 million, more than 100,000 women of fertile age are estimated to suffer from AUFI. Introduction of UTx as an infertility treatment in this region will certainly differ in specific countries from ethical, religious and legal standpoints depending on culture and religion. The MENAT region is the cradle of three religions and the geographic area encompasses a variety of cultures and religions with different views on assisted reproduction. In light of these issues, the aim of this article is to give an overview of the research-based development of UTx and its clinical results up until today as well as to explore how UTx would fit into current infertility treatments in the MENAT region, with its existing multifaceted religious perspectives. (C) 2017 Middle East Fertility Society. Production and hosting by Elsevier B.V.
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