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Sökning: WFRF:(Hansson Anders 1978 )

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  • Gourdon, Pontus, et al. (författare)
  • Optimized in vitro and in vivo expression of proteorhodopsin : a seven-transmembrane proton pump
  • Ingår i: Protein Expression and Purification. - : Academic Press. - 1046-5928 .- 1096-0279. ; 58:1, s. 13-103
  • Tidskriftsartikel (refereegranskat)abstract
    • Proteorhodopsin is an integral membrane light-harvesting proton pump that is found in bacteria distributed throughout global surface waters. Here, we present a protocol for functional in vitro production of pR using a commercial cell-free synthesis system yielding 1.0mg purified protein per milliliter of cell lysate. We also present an optimized protocol for in vivo over-expression of pR in Escherichia coli, and a two-step purification yielding 5mg of essentially pure functional protein per liter of culture. Both approaches are straightforward, rapid, and easily scalable. Thus either may facilitate the exploitation of pR for commercial biotechnological applications. Finally, the implications of some observations of the in vitro synthesis behavior, as well as preliminary results towards a structural determination of pR are discussed.
  • Ahlqvist, E., et al. (författare)
  • Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
  • 2018
  • Ingår i: Lancet Diabetes & Endocrinology. - : Elsevier. - 2213-8587. ; 6:5, s. 361-369
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis. Methods We did data-driven cluster analysis (k-means and hierarchical clustering) in patients with newly diagnosed diabetes (n=8980) from the Swedish All New Diabetics in Scania cohort. Clusters were based on six variables (glutamate decarboxylase antibodies, age at diagnosis, BMI, HbA(1c), and homoeostatic model assessment 2 estimates of beta-cell function and insulin resistance), and were related to prospective data from patient records on development of complications and prescription of medication. Replication was done in three independent cohorts: the Scania Diabetes Registry (n=1466), All New Diabetics in Uppsala (n=844), and Diabetes Registry Vaasa (n=3485). Cox regression and logistic regression were used to compare time to medication, time to reaching the treatment goal, and risk of diabetic complications and genetic associations. Findings We identified five replicable clusters of patients with diabetes, which had significantly different patient characteristics and risk of diabetic complications. In particular, individuals in cluster 3 (most resistant to insulin) had significantly higher risk of diabetic kidney disease than individuals in clusters 4 and 5, but had been prescribed similar diabetes treatment. Cluster 2 (insulin deficient) had the highest risk of retinopathy. In support of the clustering, genetic associations in the clusters differed from those seen in traditional type 2 diabetes. Interpretation We stratified patients into five subgroups with differing disease progression and risk of diabetic complications. This new substratification might eventually help to tailor and target early treatment to patients who would benefit most, thereby representing a first step towards precision medicine in diabetes.
  • Andersson, Malin E, 1978, et al. (författare)
  • Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
  • 2007
  • Ingår i: International journal of molecular medicine. - : D.A. Spandidos. - 1107-3756 .- 1791-244X. ; 20:2, s. 233-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Kinesin is a microtubule-associated motor protein that transports Alzheimer-associated amyloid precursor protein (APP) in neurons. In animal models, impaired kinesin-mediated APP transport seems to enhance formation of the neurotoxic 42 amino acid fragment of beta-amyloid (A beta 42). In man, one study suggests that a polymorphism (rs8702, 56,836G>C) in the kinesin light chain 1 gene (KNS2) may affect the risk of Alzheimer's disease (AD). To further assess KNS2 as a susceptibility gene for AD we analyzed 802 patients with sporadic AD and 286 controls, 134 longitudinally followed patients with mild cognitive impairment (MCI) and 39 cognitively stable controls for the rs8702 polymorphism. The rs8702 polymorphism did not influence risk of AD (p=0.46). However, rs8702 interacted with APOE epsilon 4 carrier status in AD (p=0.006) and influenced cerebrospinal fluid levels of hyperphosphorylated tau in MCI patients who converted to AD during follow-up (p=0.018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis.
  • Axehill, Daniel, 1978- (författare)
  • Applications of Integer Quadratic Programming in Control and Communication
  • 2005
  • Licentiatavhandling (övrigt vetenskapligt)abstract
    • The main topic of this thesis is integer quadratic programming with applications to problems arising in the areas of automatic control and communication. One of the most widespread modern control principles is the discrete-time method Model Predictive Control (MPC). The main advantage with MPC, compared to most other control principles, is that constraints on control signals and states can easily be handled. In each time step, MPC requires the solution of a Quadratic Programming (QP) problem. To be able to use MPC for large systems, and at high sampling rates, optimization routines tailored for MPC are used. In recent years, the range of application of MPC has been extended from constrained linear systems to so-called hybrid systems. Hybrid systems are systems where continuous dynamics interact with logic. When this extension is made, binary variables are introduced in the problem. As a consequence, the QP problem has to be replaced by a far more challenging Mixed Integer Quadratic Programming (MIQP) problem. Generally, for this type of optimization problems, the computational complexity is exponential in the number of binary optimization variables. In modern communication systems, multiple users share a so-called multi-access channel, where the information sent by different users is separated by using almost orthogonal codes. Since the codes are not completely orthogonal, the decoded information at the receiver is slightly correlated between different users. Further, noise is added during the transmission. To estimate the information originally sent, a maximum likelihood problem involving binary variables is solved. The process of simultaneously estimating the information sent by multiple users is called multiuser detection. In this thesis, the problem to efficiently solve MIQP problems originating from MPC is addressed. Two different algorithms are presented. First, a polynomial complexity preprocessing algorithm for binary quadratic programming problems is presented. By using the algorithm, some, or all, binary variables can be computed efficiently already in the preprocessing phase. In simulations, the algorithm is applied to unconstrained MPC problems with a mixture of real and binary control signals. It has also been applied to the multiuser detection problem, where simulations have shown that the bit error rate can be significantly reduced by using the proposed algorithm as compared to using common suboptimal algorithms. Second, an MIQP algorithm tailored for MPC is presented. The algorithm uses a branch and bound method where the relaxed node problems are solved by a dual active set QP algorithm. In this QP algorithm, the KKT-systems are solved using Riccati recursions in order to decrease the computational complexity. Simulation results show that both the QP solver and the MIQP solver proposed have lower computational complexity than corresponding generic solvers.
  • Friedrich, Jana, et al. (författare)
  • Investigating hypoxia in aquatic environments: diverse approaches to addressing a complex phenomenon
  • 2014
  • Ingår i: Biogeosciences. - 1726-4170 .- 1726-4189. ; 11
  • Tidskriftsartikel (refereegranskat)abstract
    • In this paper we provide an overview of new knowledge on oxygen depletion (hypoxia) and related phenomena in aquatic systems resulting from the EU-FP7 project HYPOX (“In situ monitoring of oxygen depletion in hypoxic ecosystems of coastal and open seas, and landlocked water bodies”, www.hypox.net). In view of the anticipated oxygen loss in aquatic systems due to eutrophication and climate change, HYPOX was set up to improve capacities to monitor hypoxia as well as to understand its causes and consequences. Temporal dynamics and spatial patterns of hypoxia were analyzed in field studies in various aquatic environments, including the Baltic Sea, the Black Sea, Scottish and Scandinavian fjords, Ionian Sea lagoons and embayments, and Swiss lakes. Examples of episodic and rapid (hours) occurrences of hypoxia, as well as seasonal changes in bottom-water oxygenation in stratified systems, are discussed. Geologically driven hypoxia caused by gas seepage is demonstrated. Using novel technologies, temporal and spatial patterns of watercolumn oxygenation, from basin-scale seasonal patterns to meter-scale sub-micromolar oxygen distributions, were resolved. Existing multidecadal monitoring data were used to demonstrate the imprint of climate change and eutrophication on long-term oxygen distributions. Organic and inorganic proxies were used to extend investigations on past oxygen conditions to centennial and even longer timescales that cannot be resolved by monitoring. The effects of hypoxia on faunal communities and biogeochemical processes were also addressed in the project. An investigation of benthic fauna is presented as an example of hypoxia-devastated benthic communities that slowly recover upon a reduction in eutrophication in a system where naturally occurring hypoxia overlaps with anthropogenic hypoxia. Biogeochemical investigations reveal that oxygen intrusions have a strong effect on the microbially mediated redox cycling of elements. Observations and modeling studies of the sediments demonstrate the effect of seasonally changing oxygen conditions on benthic mineralization pathways and fluxes. Data quality and access are crucial in hypoxia research. Technical issues are therefore also addressed, including the availability of suitable sensor technology to resolve the gradual changes in bottom-water oxygen in marine systems that can be expected as a result of climate change. Using cabled observatories as examples, we show how the benefit of continuous oxygen monitoring can be maximized by adopting proper quality control. Finally, we discuss strategies for state-of-the-art data archiving and dissemination in compliance with global standards, and how ocean observations can contribute to global earth observation attempts.
  • Galis, Vasilis, 1978-, et al. (författare)
  • Partisan Scholarship in Technoscientific Controversies : Reflections on Research Experience
  • 2012
  • Ingår i: Science as Culture. - London : Routledge. - 0950-5431 .- 1470-1189. ; 21:3, s. 335-364
  • Tidskriftsartikel (refereegranskat)abstract
    • Several academic traditions have addressed epistemological objectivity and/or partisanship in the study of technoscientific controversies. On the one hand, positivist andrelativist scholars agree that the political commitments of the social researcher should notimpinge on scientific enquiry, while on the other hand, feminist and Marxist scholars notonly take stands in diverse technoscientific debates, but even claim their agendas to bemore credible than those of orthodox scientists. Such perspectives stress that all researchis partisan in one way or another because it involves questions of who controls,manipulates, and establishes decisions, facts, and knowledge. With this in mind, it ispossible to identify different forms of partisan research including capture byparticipants, de facto and overt partisanship, and mercenary scholarship. These differentforms of partisan scholarship are characterised by differences in the motives underlyingepistemological choices of research topic and method, personal commitments to thefields studied, use of research findings in controversies, and positioning of results inwider debates. Two examples help to illustrate partisan scholarship: first, a study of newtechnologies for managing climate change (carbon dioxide capture and storage); andsecond, the construction of the new underground metro system in Athens and itsaccommodation of accessibility standards. Both cases entail partisan positions and raisesimilar concerns about the orthodox epistemological assumptions underpinningsociotechnical systems, especially when it comes to technoscientific controversies.Supporting STS partisan scholarship, therefore, enables greater social and democraticengagement with technoscientific development.
  • Hansson, Marit, et al. (författare)
  • Interleukin-22 produced by alveolar macrophages during activation of the innate immune response
  • 2013
  • Ingår i: Inflammation Research. - 1023-3830. ; 62:6, s. 561-569
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective and design Interleukin (IL)-22 is important for mucosal host defense. Whereas previous studies focus on lymphocytes as sources of IL-22, we determined whether IL-22 is produced by inflammatory cells in the lungs other than T-lymphocytes during the activation of the innate immune response. Material, methods and treatment Inflammatory cells in the lungs of Balb/c mice were primed by endotoxin (LPS, 10 μg) or peptidoglycan (PG, 40 μg) intranasally (3 days). After CD3 + cell depletion, lung homogenates were re-stimulated 24 h with LPS (100 ng/ml), PG (10 μg/ml), IL-23 (100 ng/ml) or vehicle. Human BAL macrophages were stimulated 24 h with PG (50 μg/ml) and IL-23 (100 ng/ml) or vehicle. The release of IL-22 was measured with ELISA and intracellular IL-22 with immunostaining. For statistics, either Dunnett or Students t test method was employed (n = 3–8). Results Re-stimulation in vitro increased concentrations of mouse IL-22 protein irrespective of priming in vivo. A majority of macrophages in mouse lung and BAL samples displayed immunostaining for IL-22. In analogy, human BAL macrophages released IL-22 protein, and a third of these cells displayed immunostaining for IL-22. Conclusions Alveolar macrophages can produce and release IL-22 during the activation of the innate immune response and thereby constitute a potentially important regulator of mucosal host defence in the lungs.
  • Kindlund, Bert, 1969, et al. (författare)
  • CD4(+) regulatory T cells in gastric cancer mucosa are proliferating and express high levels of IL-10 but little TGF-β.
  • 2017
  • Ingår i: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. - 1436-3291 .- 1436-3305. ; 20:1
  • Tidskriftsartikel (refereegranskat)abstract
    • An increase of regulatory T cells, defined as CD25(high)- and/or FOXP3(+)-expressing CD4(+) T cells, within tumors has been reported in several studies. Tregs promote tumor growth by modulating the antitumor immune response, mainly through inhibition of T-cell-mediated tumor cell killing: this has been suggested to be dependent on IL-10 and/or TGF-β. In stomach cancer, the mechanisms behind the accumulation of Tregs in tumor tissue has not been fully elucidated, and neither has Treg gene expression in situ.
  • Meier, Marcus, et al. (författare)
  • Comparing reconstructed past variations and future projections of the Baltic Sea ecosystem : First results from multi-model ensemble simulations
  • 2012
  • Ingår i: Ecosupport. - : Institute of Physics Publishing (IOPP). ; 7:3, s. 034005-
  • Tidskriftsartikel (refereegranskat)abstract
    • Multi-model ensemble simulations for the marine biogeochemistry and food web of the Baltic Sea were performed for the period 1850–2098, and projected changes in the future climate were compared with the past climate environment. For the past period 1850–2006, atmospheric, hydrological and nutrient forcings were reconstructed, based on historical measurements. For the future period 1961–2098, scenario simulations were driven by regionalized global general circulation model (GCM) data and forced by various future greenhouse gas emission and air- and riverborne nutrient load scenarios (ranging from a pessimistic 'business-as-usual' to the most optimistic case). To estimate uncertainties, different models for the various parts of the Earth system were applied. Assuming the IPCC greenhouse gas emission scenarios A1B or A2, we found that water temperatures at the end of this century may be higher and salinities and oxygen concentrations may be lower than ever measured since 1850. There is also a tendency of increased eutrophication in the future, depending on the nutrient load scenario. Although cod biomass is mainly controlled by fishing mortality, climate change together with eutrophication may result in a biomass decline during the latter part of this century, even when combined with lower fishing pressure. Despite considerable shortcomings of state-of-the-art models, this study suggests that the future Baltic Sea ecosystem may unprecedentedly change compared to the past 150 yr. As stakeholders today pay only little attention to adaptation and mitigation strategies, more information is needed to raise public awareness of the possible impacts of climate change on marine ecosystems.
  • Stigson, Peter, et al. (författare)
  • Prospects for Swedish acceptance of carbon dioxide storage in the Baltic Sea : Learning from other energy projects
  • 2016
  • Ingår i: BASTOR2. - : John Wiley & Sons. ; 6:2, s. 188-196
  • Tidskriftsartikel (refereegranskat)abstract
    • As initiatives are taken in Sweden to evaluate the geological potential for carbon dioxide storage in the adjacent Baltic Sea, experiences from elsewhere may provide lessons about perceptions of and potential opposition toward carbon capture and storage (CCS). A comprehensive analysis of storage feasibility needs to include the issue of social acceptance. The knowledge of CCS is low in Sweden however and there are no Swedish CCS projects to learn from. This paper therefore draws on lessons from other large-scale energy projects that are embedded in similar Baltic Sea contexts to complement lessons on CCS acceptance provided in the literature. The aim of this study is to facilitate an understanding of acceptance of potential future CO2 storage initiatives in the Swedish Baltic Sea region and to analyze what contextual factors are likely to be determinative of the outcome of these and similar projects. The study identifies climate change as one such key contextual factor, which can often be used both to support and oppose a large-scale energy project. Furthermore, the study finds that there are perceptions of uncertainties regarding the regulatory framework that need to be ad-ressed in order to facilitate the planning of CCS projects in the region.
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