| 1. |
- Azimi, Alireza, et al.
(author)
-
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
- 2018
-
In: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 14:3
-
Journal article (peer-reviewed)abstract
- Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of therapy-resistant melanomas. Unfortunately, our data show that this combination elicits a heterogeneous response in a panel of melanoma cell lines including PDX-derived models. We sought to understand the mechanisms underlying the differential responses and suggest a patient stratification strategy. Thermal proteome profiling (TPP) identified the protein targets of XL888 in a pair of sensitive and unresponsive cell lines. Unbiased proteomics and phosphoproteomics analyses identified CDK2 as a driver of resistance to both BRAF and Hsp90 inhibitors and its expression is regulated by the transcription factor MITF upon XL888 treatment. The CDK2 inhibitor, dinaciclib, attenuated resistance to both classes of inhibitors and combinations thereof. Notably, we found that MITF expression correlates with CDK2 upregulation in patients; thus, dinaciclib would warrant consideration for treatment of patients unresponsive to BRAF-MEK and/or Hsp90 inhibitors and/or harboring MITF amplification/overexpression.
|
|
| 2. |
- Flodén, Jonas, 1974, et al.
(author)
-
Shipping in the EU emissions trading system: implications for mitigation, costs and modal split
- 2024
-
In: Climate Policy. - Stockholm : IVL Svenska Miljöinstitutet. - 1752-7457 .- 1469-3062. ; 24:7, s. 969-987
-
Journal article (peer-reviewed)abstract
- EU recently decided to include shipping, meaning all intra-European shipping and 50% of extra-European voyages, in the EU Emissions Trading System (ETS) beginning in 2024. This article provides an early assessment of the impacts of the EU ETS on the shipping sector’s potential reductions in greenhouse gas emissions for different types of ships. It further examines selected mitigation measures and the impact on modals split and costs. The study employs a mixed-methods approach combining quantitative estimates (based on data from the EU monitoring, reporting and verification system) with qualitative data and information from interviews with key actors and from previous literature. This approach aims to provide a comprehensive understanding of the impacts of the EU ETS. The inclusion of shipping in the EU ETS is expected to introduce significant incentives to reduce emissions. We estimate that switching to bio-methanol at an emissions allowance price of €90–100/tCO2 will be cost-effective for a minor share of shipping segments (representing about 0.5-5% of all ships), whereas at a price above €150/tCO2 it could be cost-effective for a considerable share (potentially 75%) of ships. In the short term, the costs incurred by the EU ETS will be passed on to transport customers as a surcharge. The increased cost may, unless properly addressed, drive carbon leakage. Meanwhile, a modal shift away from shipping may occur in the roll-on, roll-off (RoRo) and roll-on passenger (RoPax) segments due to direct competition with road and rail transport and the relative ease of shifting to other modes of transport.
|
|
| 3. |
- Fredricsson, Malin, et al.
(author)
-
Nationell luftövervakning Sakrapport med data från övervakning inom Programområde Luft t.o.m 2019
- 2021
-
Reports (other academic/artistic)abstract
- Naturvårdsverket ansvarar för den nationella luftövervakningen i bakgrundsmiljö i Sverige. I rapporten redovisas resultat från verksamheten inom Programområde Luft avseende mätningar (genomförda av IVL, SU, SLU och SMHI) till och med 2019 och regionala modellberäkningar (utförda av SMHI) till och med 2018.För flertalet av de luftföroreningskomponenter som övervakas inom den nationella miljöövervakningen har det, sedan mätningarna startade för mellan 20 och 40 år sedan, generellt sett skett en avsevärd förbättring avseende såväl halter i luft som deposition i bakgrundsmiljö. Utvecklingen har dock varierat i något olika utsträckning beroende på komponenter och lokalisering i landet. Föroreningsbelastningen är oftast lägre ju längre norrut i landet man kommer.För de flesta ämnen som det finns miljökvalitetsnormer (MKN) respektive miljömål för ligger halterna i regional bakgrund avsevärt lägre än angivna gräns- och målvärden. Halterna av ozon överskrider dock i dagsläget (2019) MKN för hälsa.
|
|
| 4. |
- Vihinen, Pia, et al.
(author)
-
Benefit of adjuvant interferon alfa-2b (IFN-α) therapy in melanoma patients with high serum MMP-8 levels.
- 2014
-
In: Cancer Immunology, Immunotherapy. - : Springer Science and Business Media LLC. - 1432-0851 .- 0340-7004.
-
Journal article (peer-reviewed)abstract
- Matrix metalloproteinases (MMPs) are important enzymes in tissue turnover and various inflammatory processes. In this study, it was evaluated whether serum MMP-8 can predict the response to adjuvant interferon alfa-2b (IFN-α) therapy in patients with operated high-risk cutaneous melanoma. Pre-treatment sera from 460 patients with stage IIB-IIIC melanoma were analyzed for MMP-8. The patients were randomized after surgery to adjuvant IFN-α for 12 or 24 months (n = 313) or observation only (n = 147). The median serum MMP-8 level was used to classify the patients into a low MMP-8 (n = 232) and a high MMP-8 (n = 228) group. In the high MMP-8 subgroup, IFN-α therapy significantly improved relapse-free survival (RFS). RFS was 36.8 months in patients with high MMP-8 levels receiving IFN-α therapy, whereas RFS for those with high MMP-8 levels with observation only was 10.6 months (P = 0.027). Median overall survival for patients with high MMP-8 and observation only was 36.7 versus 71.7 months in those receiving IFN-α (P = 0.13). In a multivariate model, IFN-α therapy was a significant predictor of favorable RFS (HR 0.74; 95 % CI 0.55-0.99; P = 0.048), after adjustment for pre-treatment MMP-8 (HR 1.17; 95 % CI 0.88-1.55; P = 0.28), gender (HR 1.16; 95 % CI 0.86-1.56; P = 0.32), age (HR 1.00; 95 % CI 1.00-1.02; P = 0.12), ulceration (HR 1.09; 95 % CI 0.81-1.46; P = 0.58), and the presence of node metastases (HR 1.36; 95 % CI 1.17-1.58; P
|
|
| 5. |
- Antinyan, Vard, 1984, et al.
(author)
-
Monitoring Evolution of Code Complexity in Agile/Lean Software Development - A Case Study at Two Companies
- 2013
-
In: 13th Symposium on Programming Languages and Software Tools, SPLST 2013 - Proceedings. - 9789633062289 ; , s. 1-15
-
Conference paper (peer-reviewed)abstract
- One of the distinguishing characteristics of Agile and Lean software development is that software products “grow” with new functionality with relatively small increments. Continuous customer demands of new features and the companies’ abilities to deliver on those demands are the two driving forces behind this kind of software evolution. Despite the numerous benefits there are a number of risks associated with this kind of growth. One of the main risks is the fact that the complexity of the software product grows slowly, but over time reaches scales which makes the product hard to maintain or evolve. The goal of this paper is to present a measurement system for monitoring the growth of complexity and drawing attention when it becomes problematic. The measurement system was developed during a case study at Ericsson and Volvo Group Truck Technology. During the case study we explored the evolution of size, complexity, revisions and number of designers of two large software products from the telecom and automotive domains. The results show that two measures needed to be monitored to keep the complexity development under control - McCabe’s complexity and number of revisions.
|
|
| 6. |
- Arehag, Marie, 1952, et al.
(author)
-
Outcomes-focused evaluation of engineering programs - Inhibitor or stimulant for improvement?
- 2013
-
In: Proceedings of the 9th International CDIO Conference, Cambridge, USA.
-
Conference paper (peer-reviewed)abstract
- In Sweden, a new model for quality evaluation of higher education is being introduced. It is internationally unique. A very strong emphasis on assessing the quality of an entire education through its outcomes, defined by samples of final degree reports, is perhaps the most original feature of the model. This is claimed to enable a direct assessment of quality rather than the indirect assessment used in conventional models. The model has, however, been intensively debated during its development and first years of use. The aims of this paper are first to evaluate in what ways and to what extent the Swedish national model for evaluation of higher education contributes to the quality improvement of the evaluated programs, and second to describe and evaluate an approach for organizing the project to prepare the evaluation documentation for a large-scale education evaluation. The paper concludes that on an overall and averaged level, the project participants estimated that the model will contribute to positive effects. Specific areas are identified including ethics and focus of final degree reports. However, there is a strong variance in the data: There is a substantial fraction of participants who have not identified any improvements or weak spots, and who do not think that the evaluation preparation will positively affect education quality development. Chalmers University of Technology chose to approach the evaluation with a centrally managed project. The setup gave possibilities for rationalization through common training, supporting materials, a common document database and for information sharing across departmental boundaries. Nevertheless, the project was very time-consuming with an average of 540 hours spent for each program/degree.
|
|
| 7. |
|
|
| 8. |
- Bertilsson, Filip, et al.
(author)
-
Centralized versus Distributed Nonlinear Model Predictive Control for Online Robot Fleet Trajectory Planning
- 2022
-
In: IEEE International Conference on Automation Science and Engineering. - 2161-8070 .- 2161-8089. ; 2022-August, s. 701-706
-
Conference paper (peer-reviewed)abstract
- In this paper, we formulate and evaluate a centralized vs. a distributed approach for online trajectory generation for a fleet of mobile robots in the presence of static and dynamic obstacles. Due to dynamic obstacles, the trajectories need to be updated online and this is formulated as a nonlinear model predictive control problem. We show that both centralized and distributed MPC solvers manage to generate smooth collision-free trajectories. The distributed approach is shown to scale to many robots very well. In contrast, the computational cost of the centralized approach increases with the number of robots. However, the trajectories generated by the distributed control approach have larger deviations than those generated by the centralized approach. The experiments suggest that the centralized method should be chosen with sufficient computation resource while the distributed approach is a viable alternative when the number of robots is considerable.
|
|
| 9. |
- Carlson, Johan, 1972, et al.
(author)
-
Robot Station Optimization for Minimizing Dress Pack Problems
- 2016
-
In: Procedia CIRP. - : Elsevier BV. - 2212-8271. ; 44, s. 389-394
-
Conference paper (peer-reviewed)abstract
- Problems with robot dress packs are one of the major reasons for online adjustments of robot motions and for down time in robot stations. A factory study showed that many robots wear out more than one dress pack per year. The life length variation was in fact shown considerable, ranging from years to only months. The dress packs consist of attached cables and hoses which typically have significant impact on allowed robot configurations and motions in the station. In this paper, we present novel simulation methods for improving robot configurations and motions during off-line programming and optimization of robot stations. The proposed method is applied to a stud welding station resulting in the elimination of several problems related to the dress packs.
|
|
| 10. |
- Cintas Sanchez, Olivia, 1982, et al.
(author)
-
The potential role of forest management in Swedish scenarios towards climate neutrality by mid century
- 2017
-
In: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 383:January, s. 73-84
-
Journal article (peer-reviewed)abstract
- Swedish climate policy targets net zero greenhouse gases (GHG) by mid-century, with road transport independent of fossil fuels by 2030, requiring far-reaching changes in the way energy is used. Forest management is expected to support carbon sequestration and provide biomass for various uses, including energy. In this paper, we combine two energy scenarios with four forest scenarios and quantify GHG balances associated with energy-use for heat, electricity, and road transport, and with forest management and production, use, and end-of-life management of various forest products, including products for export. The aggregated GHG balances are evaluated in relation to the 2-degree target and an allocated Swedish CO2 budget. The production of biofuels in the agriculture sector is considered but not analyzed in detail.The results suggest that Swedish forestry can make an important contribution by supplying forest fuels and other products while maintaining or enhancing carbon storage in vegetation, soils, and forest products. The GHG neutrality goal is not met in any of the scenarios without factoring in carbon sequestration. Measures to enhance forest productivity can increase output of forest products (including biofuels for export) and also enhance carbon sequestration. The Swedish forest sector can let Sweden reach net negative emissions, and avoid “using up” its allocated CO2 budget, thereby increasing the associated emissions space for the rest of the world.
|
|
