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Träfflista för sökning "WFRF:(Hansson Mikael 1975 ) ;pers:(Zetterberg Henrik 1973)"

Search: WFRF:(Hansson Mikael 1975 ) > Zetterberg Henrik 1973

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1.
  • Bridel, Claire, et al. (author)
  • Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology : A Systematic Review and Meta-analysis
  • 2019
  • In: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:9, s. 1035-1048
  • Research review (peer-reviewed)abstract
    • Importance  Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date.Objectives  To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions.Data Sources  PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC.Study Selection  Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex.Data Extraction and Synthesis  Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept.Main Outcome and Measure  The cNfL levels adjusted for age and sex across diagnoses.Results  Data were collected for 10 059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC. The cNfL overlapped in most clinically similar diagnoses except for FTD and iHIV, which segregated from other dementias, and PD, which segregated from atypical parkinsonian syndromes.Conclusions and Relevance  These data support the use of cNfL as a biomarker of neuroaxonal damage and indicate that age-specific and sex-specific (and in some cases disease-specific) reference values may be needed. The cNfL has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
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2.
  • Lautner, Ronald, et al. (author)
  • Apolipoprotein e genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.
  • 2014
  • In: JAMA psychiatry. - : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 71:10, s. 1183-91
  • Journal article (peer-reviewed)abstract
    • Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
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  • Result 1-2 of 2
Type of publication
journal article (1)
research review (1)
Type of content
peer-reviewed (2)
Author/Editor
Blennow, Kaj, 1958 (2)
Zetterberg, Henr... (2)Undo refine
Wallin, Anders, 1950 (2)
Landén, Mikael, 1966 (2)
Hansson, Oskar (2)
Andreasson, Ulf, 196 ... (2)
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Minthon, Lennart (1)
Kuhle, Jens (1)
Gisslén, Magnus, 196 ... (1)
Lycke, Jan, 1956 (1)
Khademi, Mohsen (1)
Olsson, Tomas (1)
Piehl, Fredrik (1)
Wikkelsö, Carsten, 1 ... (1)
Johannsson, Gudmundu ... (1)
Janelidze, Shorena (1)
Olsson, Bob, 1969 (1)
Teunissen, Charlotte ... (1)
Palmqvist, Sebastian (1)
Leinonen, Ville (1)
Axelsson, Markus, 19 ... (1)
Forsgren, Lars (1)
Svenningsson, Anders (1)
Christensen, Jeppe R ... (1)
Paterson, Ross W (1)
Schott, Jonathan M (1)
Burman, Joachim, 197 ... (1)
Ewers, Michael (1)
Gunnarsson, Martin, ... (1)
Brundin, Lou (1)
Verbeek, Marcel M (1)
Lautner, Ronald (1)
Mattsson, Niklas, 19 ... (1)
Mattsson, Niklas (1)
Skillbäck, Tobias (1)
van Swieten, John C (1)
Visser, Pieter Jelle (1)
Bjerke, Maria (1)
Hall, Sara (1)
Hampel, Harald (1)
Malaspina, Andrea (1)
Turner, Martin R (1)
Jonsson, Michael, 19 ... (1)
Wild, Edward J (1)
Rujescu, Dan (1)
Boxer, Adam (1)
Rojas, Julio C. (1)
Herukka, Sanna-Kaisa (1)
Sandberg, Linda (1)
Bridel, Claire (1)
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University
University of Gothenburg (2)
Karolinska Institutet (2)
Uppsala University (1)
Örebro University (1)
Lund University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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