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- Lutz, JM, et al.
(författare)
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Occupational risks for uveal melanoma results from a case-control study in nine European countries
- 2005
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 16:4, s. 437-447
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Tidskriftsartikel (refereegranskat)abstract
- Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.
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- Schildt, E. B., et al.
(författare)
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Occupational exposures as risk factors for oral cancer evaluated in a Swedish case-control study.
- 1999
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Ingår i: Oncology Reports. - 1021-335X. ; 6:2, s. 317-320
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Tidskriftsartikel (refereegranskat)abstract
- In a case-control study with 410 cases and 410 matched controls from the period 1980-1989 we investigated the role of occupations and occupational exposures as risk factors for squamous cell oral cancer. All subjects received a questionnaire. The response rates were 96% and 91% for cases and controls, respectively. A significantly increased risk was found for pulp industry workers, odds ratio (OR) 4.0 and wood or product workers, OR 5.5. Exposure to chemicals such as phenoxyacetic acids yielded an OR of 1.7. The positive findings in this study may be explained by exposure to chemicals, but need to be verified in further studies.
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- Schildt, E. B., et al.
(författare)
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Oral infections and dental factors in relation to oral cancer : A Swedish case-control study
- 1998
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Ingår i: European Journal of Cancer Prevention. - : Ovid Technologies (Wolters Kluwer Health). - 0959-8278. ; 7:3, s. 201-206
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the role of oral infections, dentition and dental X- rays for oral cancer in a north Swedish population. This case-control study consisted of 410 cases with oral cancer for the period 1980-89 and 410 matched controls. All subjects received a mailed questionnaire. The response rates were 96% and 91% for cases and controls, respectively. The univariate analysis showed a statistically significant increased risk for oral cancer among individuals reporting problems with recurrent clinical oral infection (odds ratio (OR) 3.8). Separate analyses were made for groups with a clearly stated HSV-1 infection (OR 1.9) and highly suspected HSV-1 infection (OR 3.3) as reported by the subjects. Odds ratios were also calculated for infections in relation to tobacco and alcohol habits. For individuals reporting recurrent infection problems an increased risk was observed in every combination category. Dental factors such as different fillings, dentures and fixed prostheses showed no increased risks. Dental X-ray did not produce an increased OR either. A multivariate analysis suggested that the most important risk factors were oral infections followed by liquor consumption and active smoking.
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