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Genome-wide associa...
Genome-wide association study identifies eight loci associated with blood pressure
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Newton-Cheh, Christopher (author)
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Johnson, Toby (author)
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Gateva, Vesela (author)
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show more...
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Tobin, Martin D. (author)
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Bochud, Murielle (author)
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Coin, Lachlan (author)
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Najjar, Samer S. (author)
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Zhao, Jing Hua (author)
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Heath, Simon C. (author)
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Eyheramendy, Susana (author)
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Papadakis, Konstantinos (author)
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Voight, Benjamin F. (author)
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Scott, Laura J. (author)
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Zhang, Feng (author)
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Farrall, Martin (author)
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Tanaka, Toshiko (author)
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Wallace, Chris (author)
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Chambers, John C. (author)
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Khaw, Kay-Tee (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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van der Harst, Pim (author)
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Polidoro, Silvia (author)
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Grobbee, Diederick E. (author)
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Onland-Moret, N. Charlotte (author)
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Bots, Michiel L. (author)
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Wain, Louise V. (author)
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Elliott, Katherine S. (author)
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Teumer, Alexander (author)
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Luan, Jian'an (author)
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Lucas, Gavin (author)
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Kuusisto, Johanna (author)
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Burton, Paul R. (author)
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Hadley, David (author)
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McArdle, Wendy L. (author)
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Brown, Morris (author)
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Dominiczak, Anna (author)
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Newhouse, Stephen J. (author)
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Samani, Nilesh J. (author)
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Webster, John (author)
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Zeggini, Eleftheria (author)
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Beckmann, Jacques S. (author)
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Bergmann, Sven (author)
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Lim, Noha (author)
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Song, Kijoung (author)
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Vollenweider, Peter (author)
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Waeber, Gerard (author)
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Waterworth, Dawn M. (author)
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Yuan, Xin (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Allione, Alessandra (author)
- Karolinska Institutet
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Di Gregorio, Alessandra (author)
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Guarrera, Simonetta (author)
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Panico, Salvatore (author)
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Ricceri, Fulvio (author)
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Romanazzi, Valeria (author)
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Sacerdote, Carlotta (author)
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Vineis, Paolo (author)
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Barroso, Ines (author)
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Sandhu, Manjinder S. (author)
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Luben, Robert N. (author)
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Crawford, Gabriel J. (author)
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Jousilahti, Pekka (author)
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Perola, Markus (author)
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Boehnke, Michael (author)
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Bonnycastle, Lori L. (author)
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Collins, Francis S. (author)
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Jackson, Anne U. (author)
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Mohlke, Karen L. (author)
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Stringham, Heather M. (author)
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Valle, Timo T. (author)
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Willer, Cristen J. (author)
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Bergman, Richard N. (author)
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Morken, Mario A. (author)
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Doering, Angela (author)
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Gieger, Christian (author)
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Illig, Thomas (author)
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Meitinger, Thomas (author)
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Org, Elin (author)
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Pfeufer, Arne (author)
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Wichmann, H. Erich (author)
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Kathiresan, Sekar (author)
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Marrugat, Jaume (author)
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O'Donnell, Christopher J. (author)
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Schwartz, Stephen M. (author)
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Siscovick, David S. (author)
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Subirana, Isaac (author)
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Freimer, Nelson B. (author)
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Hartikainen, Anna-Liisa (author)
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McCarthy, Mark I. (author)
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O'Reilly, Paul F. (author)
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Peltonen, Leena (author)
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Pouta, Anneli (author)
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de Jong, Paul E. (author)
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Snieder, Harold (author)
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van Gilst, Wiek H. (author)
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Clarke, Robert (author)
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Goel, Anuj (author)
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Hamsten, Anders (author)
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Peden, John F. (author)
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Seedorf, Udo (author)
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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Tognoni, Giovanni (author)
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Lakatta, Edward G. (author)
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Sanna, Serena (author)
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Scheet, Paul (author)
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Schlessinger, David (author)
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Scuteri, Angelo (author)
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Doerr, Marcus (author)
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Ernst, Florian (author)
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Felix, Stephan B. (author)
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Homuth, Georg (author)
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Lorbeer, Roberto (author)
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Reffelmann, Thorsten (author)
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Rettig, Rainer (author)
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Voelker, Uwe (author)
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Galan, Pilar (author)
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Gut, Ivo G. (author)
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Hercberg, Serge (author)
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Lathrop, G. Mark (author)
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Zelenika, Diana (author)
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Deloukas, Panos (author)
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Soranzo, Nicole (author)
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Williams, Frances M. (author)
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Zhai, Guangju (author)
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Salomaa, Veikko (author)
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Laakso, Markku (author)
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Elosua, Roberto (author)
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Forouhi, Nita G. (author)
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Volzke, Henry (author)
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Uiterwaal, Cuno S. (author)
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van der Schouw, Yvonne T. (author)
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Numans, Mattijs E. (author)
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Matullo, Giuseppe (author)
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Navis, Gerjan (author)
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- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Bingham, Sheila A. (author)
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Kooner, Jaspal S. (author)
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Connell, John M. (author)
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Bandinelli, Stefania (author)
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Ferrucci, Luigi (author)
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Watkins, Hugh (author)
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Spector, Tim D. (author)
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Tuomilehto, Jaakko (author)
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Altshuler, David (author)
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Strachan, David P. (author)
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Laan, Maris (author)
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Meneton, Pierre (author)
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Wareham, Nicholas J. (author)
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Uda, Manuela (author)
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Jarvelin, Marjo-Riitta (author)
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Mooser, Vincent (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Loos, Ruth J. F. (author)
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Elliott, Paul (author)
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Abecasis, Goncalo R. (author)
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Caulfield, Mark (author)
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Munroe, Patricia B. (author)
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show less...
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(creator_code:org_t)
- 2009-05-10
- 2009
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:6, s. 666-676
- Related links:
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http://dx.doi.org/10...
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https://www.pure.ed....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Newton-Cheh, Chr ...
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Johnson, Toby
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Gateva, Vesela
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Tobin, Martin D.
-
Bochud, Murielle
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Coin, Lachlan
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show more...
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Najjar, Samer S.
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Zhao, Jing Hua
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Heath, Simon C.
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Eyheramendy, Sus ...
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Papadakis, Konst ...
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Voight, Benjamin ...
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Scott, Laura J.
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Zhang, Feng
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Farrall, Martin
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Tanaka, Toshiko
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Wallace, Chris
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Chambers, John C ...
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Khaw, Kay-Tee
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Nilsson, Peter
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van der Harst, P ...
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Polidoro, Silvia
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Grobbee, Diederi ...
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Onland-Moret, N. ...
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Bots, Michiel L.
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Wain, Louise V.
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Elliott, Katheri ...
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Teumer, Alexande ...
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Luan, Jian'an
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Lucas, Gavin
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Kuusisto, Johann ...
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Burton, Paul R.
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Hadley, David
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McArdle, Wendy L ...
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Brown, Morris
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Dominiczak, Anna
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Newhouse, Stephe ...
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Samani, Nilesh J ...
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Webster, John
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Zeggini, Elefthe ...
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Beckmann, Jacque ...
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Bergmann, Sven
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Lim, Noha
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Song, Kijoung
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Vollenweider, Pe ...
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Waeber, Gerard
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Waterworth, Dawn ...
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Yuan, Xin
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Groop, Leif
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Orho-Melander, M ...
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Allione, Alessan ...
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Di Gregorio, Ale ...
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Guarrera, Simone ...
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Panico, Salvator ...
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Ricceri, Fulvio
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Romanazzi, Valer ...
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Sacerdote, Carlo ...
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Vineis, Paolo
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Barroso, Ines
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Sandhu, Manjinde ...
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Luben, Robert N.
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Crawford, Gabrie ...
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Jousilahti, Pekk ...
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Perola, Markus
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Boehnke, Michael
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Bonnycastle, Lor ...
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Collins, Francis ...
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Jackson, Anne U.
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Mohlke, Karen L.
-
Stringham, Heath ...
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Valle, Timo T.
-
Willer, Cristen ...
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Bergman, Richard ...
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Morken, Mario A.
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Doering, Angela
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Gieger, Christia ...
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Illig, Thomas
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Meitinger, Thoma ...
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Org, Elin
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Pfeufer, Arne
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Wichmann, H. Eri ...
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Kathiresan, Seka ...
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Marrugat, Jaume
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O'Donnell, Chris ...
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Schwartz, Stephe ...
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Siscovick, David ...
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Subirana, Isaac
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Freimer, Nelson ...
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Hartikainen, Ann ...
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McCarthy, Mark I ...
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O'Reilly, Paul F ...
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Peltonen, Leena
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Pouta, Anneli
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de Jong, Paul E.
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Snieder, Harold
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van Gilst, Wiek ...
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Clarke, Robert
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Goel, Anuj
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Hamsten, Anders
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Peden, John F.
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Seedorf, Udo
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Syvänen, Ann-Chr ...
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Tognoni, Giovann ...
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Lakatta, Edward ...
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Sanna, Serena
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Scheet, Paul
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Schlessinger, Da ...
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Scuteri, Angelo
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Doerr, Marcus
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Ernst, Florian
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Felix, Stephan B ...
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Homuth, Georg
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Lorbeer, Roberto
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Reffelmann, Thor ...
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Rettig, Rainer
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Voelker, Uwe
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Galan, Pilar
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Gut, Ivo G.
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Hercberg, Serge
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Lathrop, G. Mark
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Zelenika, Diana
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Deloukas, Panos
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Soranzo, Nicole
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Williams, France ...
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Zhai, Guangju
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Salomaa, Veikko
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Laakso, Markku
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Elosua, Roberto
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Forouhi, Nita G.
-
Volzke, Henry
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Uiterwaal, Cuno ...
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van der Schouw, ...
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Numans, Mattijs ...
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Matullo, Giusepp ...
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Navis, Gerjan
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Berglund, Göran
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Bingham, Sheila ...
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Kooner, Jaspal S ...
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Connell, John M.
-
Bandinelli, Stef ...
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Ferrucci, Luigi
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Watkins, Hugh
-
Spector, Tim D.
-
Tuomilehto, Jaak ...
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Altshuler, David
-
Strachan, David ...
-
Laan, Maris
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Meneton, Pierre
-
Wareham, Nichola ...
-
Uda, Manuela
-
Jarvelin, Marjo- ...
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Mooser, Vincent
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Melander, Olle
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Loos, Ruth J. F.
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Elliott, Paul
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Abecasis, Goncal ...
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Caulfield, Mark
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Munroe, Patricia ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
-
Nature Genetics
- By the university
-
Lund University
-
Karolinska Institutet
-
Uppsala University