Sökning: WFRF:(Hases Linnea)
> Berkenstam Anders >
Clinical candidate ...
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling
-
- Mesmar, Fahmi (författare)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Univ Houston, Dept Biol & Biochem, Ctr Nucl Receptors & Cell Signaling, Houston, TX USA;KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-17121 Solna, Sweden;Indiana Univ, Sch Informat Comp & Engn, Dept Intelligent Syst Engn, Bloomington, IN USA
-
- Dai, Bingbing (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
-
- Ibrahim, Ahmed (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-17121 Solna, Sweden
-
visa fler...
-
- Hases, Linnea (författare)
- Karolinska Institutet,KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-17121 Solna, Sweden;Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden
-
- Jafferali, Mohammed Hakim (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-17121 Solna, Sweden
-
- Augustine, Jithesh Jose (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
-
- DiLorenzo, Sebastian (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
-
- Kang, Ya'an (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
-
- Zhao, Yang (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Comp Sci, Houston, TX 77030 USA.
-
- Wang, Jing (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Comp Sci, Houston, TX 77030 USA.
-
- Kim, Michael (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
-
- Lin, Chin-Yo (författare)
- Univ Houston, Ctr Nucl Receptors & Cell Signaling, Dept Biol & Biochem, Houston, TX USA.
-
- Berkenstam, Anders (författare)
- Axcentua Pharmaceut AB, Stockholm, Sweden.;ABK, Stockholm, Sweden.
-
- Fleming, Jason (författare)
- Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.;H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, Tampa, FL USA.
-
- Williams, Cecilia, Professor, 1969- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, S-17121 Solna, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2019-09-30
- 2019
- Engelska.
-
Ingår i: Cancer Medicine. - : Wiley. - 2045-7634. ; 8:18, s. 7705-7719
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://onlinelibrar...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Despite advances in cancer therapeutics, pancreatic cancer remains difficult to treat and often develops resistance to chemotherapies. We have evaluated a bioavailable genistein analogue, AXP107-11 which has completed phase Ib clinical trial, as an approach to sensitize tumor cells to chemotherapy. Using organotypic cultures of 14 patient-derived xenografts (PDX) of pancreatic ductal adenocarcinoma, we found that addition of AXP107-11 indeed sensitized 57% of cases to gemcitabine treatment. Results were validated using PDX models in vivo. Further, RNA-Seq from responsive and unresponsive tumors proposed a 41-gene treatment-predictive signature. Functional and molecular assays were performed in cell lines and demonstrated that the effect was synergistic. Transcriptome analysis indicated activation of G-protein-coupled estrogen receptor (GPER1) as the main underlying mechanism of action, which was corroborated using GPER1-selective agonists and antagonists. GPER1 expression in pancreatic tumors was indicative of survival, and our study proposes that activation of GPER1 may constitute a new avenue for pancreatic cancer therapeutics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- AXP107-11
- chemoresistance
- genistein
- GPER1
- pancreatic ductal adenocarcinoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mesmar, Fahmi
-
Dai, Bingbing
-
Ibrahim, Ahmed
-
Hases, Linnea
-
Jafferali, Moham ...
-
Augustine, Jithe ...
-
visa fler...
-
DiLorenzo, Sebas ...
-
Kang, Ya'an
-
Zhao, Yang
-
Wang, Jing
-
Kim, Michael
-
Lin, Chin-Yo
-
Berkenstam, Ande ...
-
Fleming, Jason
-
Williams, Cecili ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Medicinsk biotek ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancer Medicine
- Av lärosätet
-
Kungliga Tekniska Högskolan
-
Uppsala universitet
-
Karolinska Institutet