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- Hassing, Linda, 1967, et al.
(author)
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Overweight in midlife and risk of dementia: a 40-year follow-up study
- 2009
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In: International Journal of Obesity. - : Springer. ; 33:8, s. 893-898
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Journal article (peer-reviewed)abstract
- Objective: This study examines whether overweight in midlife increases dementia risk later in life. Methods: In 1963 body mass index was assessed in 1152 participants of The Swedish Twin Registry, at the age of 45–65 years. These participants were later screened for dementia in a prospective study with up to 40 years follow-up. A total of 312 participants were diagnosed with dementia. Results: Logistic regression analyses adjusted for demographic factors, smoking and alcohol habits, indicated that men and women categorized as overweight in their midlife had an elevated risk of dementia (OR=1.59; 95% CI: 1.21–2.07, P=0.002), Alzheimer's disease (OR=1.71; 95% CI: 1.24–2.35, P=0.003), and vascular dementia (OR=1.55; 95% CI: 0.98–2.47, P=0.059). Further adjustments for diabetes and vascular diseases did not substantially affect the associations, except for vascular dementia (OR=1.36; 95% CI: 0.82–2.56, P=0.116), reflecting the significance of diabetes and vascular diseases in the etiology of vascular dementia. There was no significant interaction between overweight and APOE alt epsilon4 status, indicating that having both risk factors does not have a multiplicative effect with regard to dementia risk. Conclusions: This study gives further support to the notion that overweight in midlife increases later risk of dementia. The risk is increased for both Alzheimer's disease and vascular dementia, and follows the same pattern for men and women. Keywords: BMI, alzheimer's disease, vascular dementia, dementia, overweight, obesity
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- Lindwall, Magnus, 1975, et al.
(author)
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Psychological health in the retirement transition: Rationale and first findings in the HEalth, Ageing and Retirement Transitions in Sweden (HEARTS) study
- 2017
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In: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 8
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Journal article (peer-reviewed)abstract
- © 2017 Lindwall, Berg, Bjälkebring, Buratti, Hansson, Hassing, Henning, Kivi, König, Thorvaldsson and Johansson. From an aging research and life-course perspective, the transition to retirement marks a significant life-event and provides a unique opportunity to study psychological health and coping during a period of substantial change in everyday life. The aim of the present paper is to: (a) outline the rationale of the HEalth, Ageing and Retirement Transitions in Sweden (HEARTS) study, (b) describe the study sample, and (c) to present some initial results from the two first waves regarding the association between retirement status and psychological health. The HEARTS study is designed to annually study psychological health in the years before and following retirement, and to examine change and stability patterns related to the retirement event. Among a representative Swedish population-based sample of 14,990 individuals aged 60-66 years, 5,913 completed the baseline questionnaire in 2015. The majority of the participants (69%) completed a web-based survey, and the rest (31%) completed a paper version. The baseline HEARTS sample represents the general population well in terms of gender and age, but is more highly educated. Cross-sectional findings from the first wave showed that retired individuals demonstrated better psychological health compared to those who were still working. Longitudinal results from the first and second waves showed that individuals who retired between waves showed more positive changes in psychological health compared with those still working or previously retired.
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- Praetorius, Marcus, 1982, et al.
(author)
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Gender Differences in Cognitive Performance in Old Age: Adjusting for Longevity
- 2014
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In: GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry. - : Hogrefe Publishing Group. - 1662-9647 .- 1662-971X. ; 27:3, s. 129-134
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Journal article (peer-reviewed)abstract
- Objective: To examine gender differences in level and change of cognitive performance in the oldest old while accounting for gender differences in longevity. Method: 574 individuals, aged 80 years and older, from the OCTO Twin Study. Five cognitive domains were administered at five occasions at 2-year intervals. Results: There were no cognitive differences between men and women, with the exception that men showed a steeper rate of decline in semantic memory. This effect was driven by men who had developed dementia and declined at a faster rate than women. Conclusion: Our results support previous findings showing minor to nonexisting gender differences in cognition among nondemented individuals in very old age when taking gender differences in longevity into account.
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- Praetorius, Marcus, 1982, et al.
(author)
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Substantial effects of APOE ε4 on memory decline in very old age: Longitudinal findings from a population-based sample
- 2013
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 34:12, s. 2734-2739
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Journal article (peer-reviewed)abstract
- We examined associations between the apolipoprotein E (APOE) epsilon 4 allele and levels of performance and rates of change in cognition in late life taking incident dementia into account. The sample consisted of 482 nondemented individuals, aged 80 years and older at baseline, drawn from the OCTO twin study. A battery of 10 cognitive tests was administered at 5 occasions with measurements intervals of 2 years. We fitted hierarchical linear models with time specified as time to death and controlled for baseline age, sex, education, stroke, cardiovascular disease, hypertension, diabetes, and incident dementia. The epsilon 4 allele was significantly associated with lower levels of performance or steeper rate of decline in all 7 memory tests. Largest effect sizes were found in tests of delayed recall and recognition memory. The effects of the APOE epsilon 4 allele were, however, reduced to a nonsignificant level in all tests except 1 after accounting for incident dementia. The findings support the notion that the APOE epsilon 4 allele is associated with substantial memory decline in very old age, but as expected, the effect is largely related to incident dementia. (C) 2013 Elsevier Inc. All rights reserved.
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- Praetorius, Marcus, 1982, et al.
(author)
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THE APOE epsilon 4 GENOTYPE ACCELERATES TERMINAL DECLINE IN COGNITION IN THE OLDEST-OLD
- 2011
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In: Gerontologist. - : Oxford University Press (OUP). - 0016-9013. ; 51:Supplement 2
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Conference paper (peer-reviewed)abstract
- Several studies have been published recent years which states that differences in individual cognitive change in old age is associated with impending death. The relationship between individual cognitive change in old age and survival is however still unclear. Several issues need to be clarified. In the present study we investigated if the association between individual cognitive change and survival is mediated by differences in gene characteristics such as APOE genotype. Participants were 498 individuals aged 80+ from the longitudinal Swedish OCTOTwin study, tested at five measurement occasions. Inter-individual differences in intra-individual change were analysed using multilevel modelling (MLM) which provides both overall growth estimates for the entire sample as well as individual and within-pair variation in growth. The results showed that APOE was significantly related to differential patterns of terminal decline in all tests measuring long-term memory (semantic and episodic memory). There were non significant similar trends in almost all other tests. APOE ε4 genotype carriers had a steeper survival related decline than the other genotype carriers. The results indicate that APOE is not just the most important biological marker for developing Alzheimer’s disease. It plays, in a for dementia controlled sample, a significant role for survival related differences in cognitive change.
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