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Prognostic role of ...
Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer
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- Matikas, A. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Wang, K. (author)
- Karolinska Institutet,Karolinska Institute
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- Lagoudaki, E. (author)
- University Hospital of Heraklion
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- Acs, B. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Zerdes, I. (author)
- Karolinska Institutet,Karolinska Institute
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- Hartman, J. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Azavedo, E. (author)
- Karolinska Institute
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- Bjöhle, J. (author)
- Karolinska University Hospital
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- Carlsson, L. (author)
- Sundsvall Hospital
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- Einbeigi, Zakaria, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,South Elfsborg Hospital,Sahlgrenska University Hospital
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- Hedenfalk, I. (author)
- Lund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast and Ovarian Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Hellström, M. (author)
- Karolinska Institute
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- Lekberg, T. (author)
- Karolinska Institute,Karolinska University Hospital
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- Loman, N. (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Saracco, A. (author)
- Stockholm South General Hospital
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- von Wachenfeldt, A. (author)
- Karolinska Institute
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- Rotstein, S. (author)
- Karolinska University Hospital
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- Bergqvist, M. (author)
- Biovica
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- Bergh, J. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Hatschek, T. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Foukakis, T. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: ESMO open. - : Elsevier BV. - 2059-7029. ; 6:2
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- BACKGROUND: Emerging data support the use of thymidine kinase 1 (TK1) activity as a prognostic marker and for monitoring of response in breast cancer (BC). The long-term prognostic value of TK1 kinetics during neoadjuvant chemotherapy is unclear, which this study aimed to elucidate. METHODS: Material from patients enrolled to the single-arm prospective PROMIX trial of neoadjuvant epirubicin, docetaxel and bevacizumab for early BC was used. Ki67 in baseline biopsies was assessed both centrally and by automated digital imaging analysis. TK1 activity was measured from blood samples obtained at baseline and following two cycles of chemotherapy. The associations of TK1 and its kinetics as well as Ki67 with event-free survival and overall survival (OS) were evaluated using multivariable Cox regression models. RESULTS: Central Ki67 counting had excellent correlation with the results of digital image analysis (r= 0.814), but not with the diagnostic samples (r= 0.234), while it was independently prognostic for worse OS [adjusted hazard ratio (HRadj) = 2.72, 95% confidence interval (CI) 1.19-6.21, P= 0.02]. Greater increase in TK1 activity after two cycles of chemotherapy resulted in improved event-free survival (HRadj= 0.50, 95% CI 0.26-0.97, P= 0.04) and OS (HRadj= 0.46, 95% CI 0.95, P= 0.04). There was significant interaction between the prognostic value of TK1 kinetics and Ki67 (pinteraction 0.04). CONCLUSION: Serial measurement of serum TK1 activity during neoadjuvant chemotherapy provides long-term prognostic information in BC patients. The ease of obtaining serial samples for TK1 assessment motivates further evaluation in larger studies. Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast cancer
- longitudinal
- neoadjuvant chemotherapy
- prognosis
- thymidine kinase 1
- TK1 kinetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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ESMO open
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To the university's database
- By the author/editor
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Matikas, A.
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Wang, K.
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Lagoudaki, E.
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Acs, B.
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Zerdes, I.
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Hartman, J.
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show more...
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Azavedo, E.
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Bjöhle, J.
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Carlsson, L.
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Einbeigi, Zakari ...
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Hedenfalk, I.
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Hellström, M.
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Lekberg, T.
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Loman, N.
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Saracco, A.
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von Wachenfeldt, ...
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Rotstein, S.
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Bergqvist, M.
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Bergh, J.
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Hatschek, T.
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Foukakis, T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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ESMO open
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet