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> (2000-2004)
> Barkardottir RB >
Deletions on chromo...
Deletions on chromosome 4 in sporadic and BRCA mutated tumors and association with pathological variables
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Johannsdottir, HK (author)
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Johannesdottir, G (author)
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Agnarsson, BA (author)
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Eerola, H (author)
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Arason, A (author)
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Johannsson, OT (author)
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Heikkila, P (author)
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Egilsson, V (author)
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- Olsson, Håkan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Nevanlinna, H (author)
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Barkardottir, RB (author)
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: Anticancer research. - 1791-7530. ; 24:5A, s. 2681-2687
- Related links:
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https://lup.lub.lu.s...
Abstract
Subject headings
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- Background: Chromosomal aberrations in breast tumors from BRCA1 and BRCA2 germ-line mutation carriers are considerably more frequent than what is seen in sporadic breast tumors. According to Comparative Genomic Hybridisation analysis (CGH), deletions on chromosome 4 are one of the most frequent events in BRCA1-associated tumors, suggesting inactivation of specific tumor suppressor genes. Materials and Methods: In the present study, 16 microsatellite markers covering chromosome 4 were used to map loss of heterozygosity (LOH) in tumors from BRCA1 (n =41) as well as in tumors from BRCA2 (n = 66) mutation carriers and in tumors from unselected cases of breast cancer (n = 68). Results: The frequency of LOH in these groups ranged from 16-73% in BRCA1-associated tumors, 13-42% in BRCA2-associated tumors and 8-33% in unselected tumors. LOH was significantly more frequent in BRCA1-associated tumors as compared to BRCA2-associated tumors and unselected tumors, and particularly high (over 70%) at 4q35.2. Pathological variables that were found significantly associated (pless than or equal to0.05) with LOH at specific markers were: high percentage of cells in S-phase, negative estrogen receptor status, young age at diagnosis and large tumors. Deletion mapping indicates the existence of seven non-overlapping regions at chromosome 4, which were identified in all three groups of tumors. Three of these seven regions, 4p16.3-p16.1, 4q27-q32.1 and 4q35.1-4qter, have not been reported in breast cancer previously. Conclusion: The results manifest the frequent alterations of chromosome 4 in BRCA1-associated breast tumors and indicate the location of several genes of potential importance in breast cancer development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- BRCA2
- breast cancer
- BRCA1
- loss of heterozygosity
Publication and Content Type
- art (subject category)
- ref (subject category)
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Johannsdottir, H ...
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Johannesdottir, ...
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Agnarsson, BA
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Eerola, H
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Arason, A
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Johannsson, OT
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show more...
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Heikkila, P
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Egilsson, V
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Olsson, Håkan
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Borg, Åke
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Nevanlinna, H
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Barkardottir, RB
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Anticancer resea ...
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Lund University