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Continuous-flow LVA...
Continuous-flow LVADs in the Nordic countries : complications and mortality and its predictors
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- Braun, Oscar Ö. (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Nilsson, Johan (författare)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Artificiell intelligens och bioinformatik inom thoraxkirurgisk vetenskap,Forskargrupper vid Lunds universitet,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS),Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden
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- Gustafsson, Finn (författare)
- Rigshosp, Dept Cardiol, Copenhagen, Denmark,Copenhagen University Hospital
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- Dellgren, Goran (författare)
- Sahlgrens Univ Hosp, Dept Cardiothorac Surg, Gothenburg, Sweden,Sahlgrenska University Hospital
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- Fiane, Arnt E. (författare)
- Oslo Univ Hosp, Dept Cardiothorac Surg, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway,Oslo university hospital,University of Oslo
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- Lemstrom, Karl (författare)
- Helsinki Univ Hosp, Cardiothorac Surg Heart & Lung Ctr, Helsinki, Finland,Helsinki University Central Hospital
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- Hübbert, Laila (författare)
- Linköpings universitet,Linköping University,Karolinska Institutet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken i Norrköping
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- Hellgren, Laila (författare)
- Uppsala universitet,Thoraxkirurgi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden
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- Lund, Lars H. (författare)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden;Karolinska Univ Hosp, Heart & Vasc Theme, Dept Med, Stockholm, Sweden,Karolinska University Hospital
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(creator_code:org_t)
- 2019-03-05
- 2019
- Engelska.
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Ingår i: Scandinavian Cardiovascular Journal. - : Informa UK Limited. - 1401-7431 .- 1651-2006. ; 53:1, s. 14-20
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Abstract
Ämnesord
Stäng
- Objectives: The purpose of this study was to assess complications and mortality and its predictors, with continuous-flow left ventricular assist devices (CF-LVADs) in the Nordic Countries.Design: This was a retrospective, international, multicenter cohort study.Results: Between 1993 and 2013, 442 surgically implanted long-term mechanical assist devices were used among 8 centers in the Nordic countries. Of those, 238 were CF-LVADs (HVAD or HeartMate II) implanted in patients >18 years with complete data. Postoperative complications and survival were compared and Cox proportion hazard regression analysis was used to identify predictors of mortality. The overall Kaplan-Meier survival rate was 75% at 1 year, 69% at 2 years and 63% at 3 years. A planned strategy of destination therapy had poorer survival compared to a strategy of bridge to transplantation or decision (2-year survival of 41% vs. 76%, p < .001). The most common complications were non-driveline infections (excluding sepsis) (44%), driveline infection (27%), need for continuous renal replacement therapy (25%) and right heart failure (24%). In a multivariate model age and left ventricular diastolic dimension was left as independent risk factors for mortality with a hazard ratio of 1.35 (95% confidence interval (CI) [1.01-1.80], p = .046) per 10 years and 0.88 (95% CI [0.72-0.99], p = .044) per 5 mm, respectively.Conclusion: Outcome with CF LVAD in the Nordic countries was comparable to other cohorts. Higher age and destination therapy require particularly stringent selection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart failure
- mechanical circulatory support
- left ventricular assist device
- outcomes
- Heart failure
- left ventricular assist device
- mechanical circulatory support
- outcomes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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