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Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

Westberg, Sara (author)
Sadeghi, Arian (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi
Svensson, Emma (author)
Uppsala universitet,Klinisk immunologi
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Segall, Thomas (author)
Dimopoulou, Maria (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,University Animal Hospital
Korsgren, Olle (author)
Uppsala universitet,Klinisk immunologi
Hemminki, Akseli (author)
Loskog, Angelica S. I. (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Klinisk immunologi,,University Animal Hospital
Tötterman, Thomas H. (author)
Uppsala universitet,Klinisk immunologi
von Euler, Henrik (author)
Rönnberg, Henrik (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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 (creator_code:org_t)
 
2013
2013
English.
In: Journal of immunotherapy (1997). - 1524-9557 .- 1537-4513. ; 36:6, s. 350-358
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Malignant melanoma is a serious disease in both humans and dogs, and the high metastatic potential results in poor prognosis for many patients. Its similarities with human melanoma make spontaneous canine melanoma an excellent model for comparative studies of novel therapies and tumor biology. We report a pilot study of local adenovector CD40L (AdCD40L) immunogene treatment in 19 cases of canine melanoma (14 oral, 4 cutaneous, and 1 conjunctival). Three patients were World Health Organization stage I, 2 were stage II, 10 stage III, and 4 stage IV. One to 6 intratumoral injections of AdCD40L were given every 7 days, followed by cytoreductive surgery in 9 cases and only immunotherapy in 10 cases. Tumor tissue was infiltrated with T and B lymphocytes after treatment, suggesting immune stimulation. The best overall response included 5 complete responses, 8 partial responses, and 4 stable and 2 progressive disease statuses according to the World Health Organization response criteria. Median survival was 160 days (range, 20-1141 d), with 3 dogs still alive at submission. Our results suggest that local AdCD40L therapy is safe and could have beneficial effects in dogs, supporting further treatment development. Clinical translation to human patients is in progress.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

canine
melanoma
dogs
immunotherapy
AdCD40L
comparative oncology

Publication and Content Type

ref (subject category)
art (subject category)

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