↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Hemminki Kari) srt2:(2020);pers:(Vodickova Ludmila)"

Search: WFRF:(Hemminki Kari) > (2020) > Vodickova Ludmila

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Catalano, Calogerina, et al. (author) Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk 2020 In: Cancer Medicine. - : Wiley. - 2045-7634. ; 9:4, s. 1473-1484 Journal article (peer-reviewed)abstract Objective: The TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Czech cohort of 1424 CRC patients and 1114 healthy controls. Methods: The variants in the TLR3, CGAS, TMEM173, IKBKE, and TBK1 genes were selected using various online bioinformatic tools, such as UCSC browser, HaploReg, Regulome DB, Gtex Portal, SIFT, PolyPhen2, and miRNA prediction tools. Results: Logistic regression analysis adjusted for age and sex detected a nominal association between CRC risk and three variants, CGAS rs72960018 (OR: 1.68, 95% CI: 1.11-2.53, P-value =.01), CGAS rs9352000 (OR: 2.02, 95% CI: 1.07-3.84, P-value =.03) and TMEM173 rs13153461 (OR: 1.53, 95% CI: 1.03-2.27, P-value =.03). Their cumulative effect revealed a threefold increased CRC risk in carriers of 5-6 risk alleles compared to those with 0-2 risk alleles. Epistatic interactions between these genes and the previously genotyped IFNAR1, IFNAR2, IFNA, IFNB, IFNK, IFNW, IRF3, and IRF7 genes, were computed to test their effect on CRC risk. Overall, we obtained nine pair-wise interactions within and between the CGAS, TMEM173, IKBKE, and TBK1 genes. Two of them remained statistically significant after Bonferroni correction. Additional 52 interactions were observed when IFN variants were added to the analysis. Conclusions: Our data suggest that epistatic interactions and a high number of risk alleles may play an important role in CRC carcinogenesis, offering novel biological understanding for the CRC management.
2.	Chattopadhyay, Subhayan, et al. (author) Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance 2020 In: Leukemia. - : Springer Nature. - 0887-6924 .- 1476-5551. ; 34, s. 1187-1191 Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Vodicka, Pavel (2); Försti, Asta (2); Hemminki, Kari (2); Vodickova, Ludmi... (2)Undo refine; da Silva Filho, Migu ... (2); Merlini, Giampaolo (1); show more...; Ohlsson, Claes, 1965 (1); Naccarati, Alessio (1); Goldschmidt, Hartmut (1); Weinhold, Niels (1); Houlston, Richard (1); Hallmans, Göran, 194 ... (1); Hoffmann, Per (1); Nöthen, Markus M (1); Chattopadhyay, Subha ... (1); Jöckel, Karl-Heinz (1); Hajek, Roman (1); Pettersson-Kymmer, U ... (1); Thomsen, Hauke (1); Jiraskova, Katerina (1); Liska, Vaclav (1); Landi, Stefano (1); Catalano, Calogerina (1); Huhn, Stefanie (1); Frank, Christoph (1); Lu, Shun (1); Vymetalkova, Veronik ... (1); Levy, Miroslav (1); Vycital, Ondrej (1); Weber, Alexander N.R ... (1); Meziane, Iman (1); Schmidt, Börge (1); Milani, Paolo (1); Rowcieno, Dorota (1); Hawkins, Philip (1); Hegenbart, Ute (1); Palladini, Giovanni (1); Wechalekar, Ashutosh (1); Schönland, Stefan O (1); show less...

University: University of Gothenburg (1); Umeå University (1); Lund University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2020 (2)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view