| 1. |
- Ekström, J, et al.
(author)
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Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder
- 1984
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In: Acta Physiologica Scandinavica. - 0001-6772. ; 122:1, s. 45-48
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Journal article (peer-reviewed)abstract
- The parasympathetically denervated and distended rat urinary bladder was found to have increased fourfold in weight when examined 3 weeks postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The results suggest that the cells of the two layers increase both in size and number. Hyperplasia was, in a previous study, suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.
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| 3. |
- Borg, J., et al.
(author)
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Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
- 2016
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In: Molecular Psychiatry. - London, United Kingdom : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 51, s. 879-879
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Journal article (peer-reviewed)abstract
- The dopamine (DA) and serotonin (5-HT) neurotransmission systems are of fundamental importance for normal brain function and serve as targets for treatment of major neuropsychiatric disorders. Despite central interest for these neurotransmission systems in psychiatry research, little is known about the regulation of receptor and transporter density levels. This lack of knowledge obscures interpretation of differences in protein availability reported in psychiatric patients. In this study, we used positron emission tomography (PET) in a twin design to estimate the relative contribution of genetic and environmental factors, respectively, on dopaminergic and serotonergic markers in the living human brain. Eleven monozygotic and 10 dizygotic healthy male twin pairs were examined with PET and [(11)C]raclopride binding to the D2- and D3-dopamine receptor and [(11)C]WAY100635 binding to the serotonin 5-HT1A receptor. Heritability, shared environmental effects and individual-specific non-shared effects were estimated for regional D2/3 and 5-HT1A receptor availability in projection areas. We found a major contribution of genetic factors (0.67) on individual variability in striatal D2/3 receptor binding and a major contribution of environmental factors (pairwise shared and unique individual; 0.70-0.75) on neocortical 5-HT1A receptor binding. Our findings indicate that individual variation in neuroreceptor availability in the adult brain is the end point of a nature-nurture interplay, and call for increased efforts to identify not only the genetic but also the environmental factors that influence neurotransmission in health and disease.
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| 8. |
- Henningsson, S, et al.
(author)
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Resource dependencies in socio-technical information systems design research
- 2010
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In: Communications of the Association for Information Systems. - 1529-3181. ; 27:42
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Journal article (peer-reviewed)abstract
- An Information Systems (IS) design research project is in many aspects fundamentally different from that of traditional behaviorist research. IS design research projects with the ambition to provide socio-technical solutions to real world problems require the contribution of external stakeholders to the development, testing, and implementation of the design contribution. This article analyzes socio-technical IS design research from a resource dependency perspective. Our objective is to identify and describe critical resources that need to be secured for completion of the research. We investigate three socio-technical IS design research projects. The first project is a small-scale project on design of eLearning courses, the second is a medium-scale industry-driven project on IS integration in corporate mergers and acquisitions, and the third is a large collaborative research project with the ambition to redesign European customs using IT. The most prominent resources are human (knowledge and skills) and organizational (reputation and trust). The main strategy to deal with dependencies is incorporation of resource controllers, which create reciprocal and sequential dependencies internally. Our study shows the importance of extending the existing view of IS design research, when applied to socio-technical research, with an “initiation phase” and an “impact phase,” which are especially important in large-scale design research projects.
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