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A multi-centre coho...
A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception
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Bonduelle, M (author)
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- Wennerholm, Ulla-Britt, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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Loft, A (author)
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Tarlatzis, B C (author)
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Peters, C (author)
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Henriet, S (author)
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Mau, C (author)
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- Victorin Cederqvist, A (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi,Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
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Van Steirteghem, A (author)
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Balaska, A (author)
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Emberson, J R (author)
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Sutcliffe, A G (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Hum Reprod. ; 20:2, s. 413-9
- Related links:
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https://gup.ub.gu.se...
Abstract
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- BACKGROUND: Over a million children have been born from assisted conception worldwide. Newer techniques being introduced appear less and less 'natural', such as intracytoplasmic sperm injection (ICSI), but there is little information on these children beyond the neonatal period. METHODS: 540 ICSI conceived 5-year-old children from five European countries were comprehensively assessed, along with 538 matched naturally conceived children and 437 children conceived with standard IVF. RESULTS: Of the 540 ICSI children examined, 63 (4.2%) had experienced a major congenital malformation. Compared with naturally conceived children, the odds of a major malformation were 2.77 (95% CI 1.41-5.46) for ICSI children and 1.80 (95% CI 0.85-3.81) for IVF children; these estimates were little affected by adjustment for socio-demographic factors. The higher rate observed in the ICSI group was due partially to an excess of malformations in the (boys') urogenital system. In addition, ICSI and IVF children were more likely than naturally conceived children to have had a significant childhood illness, to have had a surgical operation, to require medical therapy and to be admitted to hospital. A detailed physical examination revealed no further substantial differences between the groups, however. CONCLUSIONS: Singleton ICSI and IVF 5-year-olds are more likely to need health care resources than naturally conceived children. Assessment of singleton ICSI and IVF children at 5 years of age was generally reassuring, however, we found that ICSI children presented with more major congenital malformations and both ICSI and IVF children were more likely to need health care resources than naturally conceived children. Ongoing monitoring of these children is therefore required.
Keyword
- Abnormalities/*epidemiology
- Child
- Preschool
- Cohort Studies
- Europe/epidemiology
- Female
- *Fertilization
- Fertilization in Vitro/*statistics & numerical data
- *Health Status
- Hospitalization/statistics & numerical data
- Humans
- Male
- Maternal Age
- Morbidity
- Paternal Age
- Physical Examination
- Sperm Injections
- Intracytoplasmic/*statistics & numerical data
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hum Reprod
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- By the author/editor
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Bonduelle, M
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Wennerholm, Ulla ...
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Loft, A
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Tarlatzis, B C
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Peters, C
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Henriet, S
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show more...
-
Mau, C
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Victorin Cederqv ...
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Van Steirteghem, ...
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Balaska, A
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Emberson, J R
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Sutcliffe, A G
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show less...
- Articles in the publication
- Hum Reprod
- By the university
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University of Gothenburg