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Sökning: WFRF:(Henriksson Karin) > Agartz I

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1.
  • Kelly, B D, et al. (författare)
  • Craniofacial dysmorphology in Swedish schizophrenia patients
  • 2005
  • Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 1600-0447 .- 0001-690X. ; 111:3, s. 202-207
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia.
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2.
  • Kelly, BD, et al. (författare)
  • Is craniofacial dysmorpholgy correlated with structural brain anomalies in schizophrenia?
  • 2005
  • Ingår i: Schizophrenia Research. - : Elsevier BV. - 0920-9964. ; 80:2-3, s. 349-355
  • Tidskriftsartikel (refereegranskat)abstract
    • This study aimed to examine the relationship between craniofacial dysmorphology and anomalies of brain morphology in schizophrenia. Assessments of craniofacial dysmorphology and magnetic resonance imaging of brain were performed independently of each other and blind to each other in 24 males with schizophrenia and 16 male controls. Ventricular cerebrospinal fluid volume was negatively correlated with total dysmorphology score in males with schizophrenia (i.e., the larger the ventricular cerebrospinal fluid volume, the lower the total dysmorphology score) but not in male controls. These findings suggest that craniofacial dysmorphology and anomalies of brain morphology may be associated with independent processes in the etiology of schizophrenia.
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  • Resultat 1-2 av 2
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Henriksson, Karin (2)
Lane, A. (2)
McNeil, Thomas (2)
Kelly, BD (1)
Kelly, B D (1)
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Kinsella, A (1)
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Karolinska Institutet (2)
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