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- Dekhtyar, Serhiy, et al.
(författare)
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A life-course study of cognitive reserve in dementia: Dementia incidence in inpatient registers and mmse test scores in a clinical study in sweden
- 2015
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5279 .- 1552-5260. ; 11:7, s. 200-201
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Tidskriftsartikel (refereegranskat)abstract
- Cognitive reserve helps mitigate the impact of pathology on the clinical expression of dementia. Education and occupational complexity are considered as contributors to reserve, although it has been argued that cognitive reserve is likely formed over the life-course. A life-course model of cognitive reserve in dementia risk has not yet been tested. We apply a life-course model and examine if school grades around age 10, formal educational attainment, and lifetime occupational complexity affect dementia incidence in inpatient registers.
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| 2. |
- Dekhtyar, Serhiy, et al.
(författare)
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A Life-Course Study of Cognitive Reserve in Dementia-From Childhood to Old Age.
- 2015
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Ingår i: The American Journal of Geriatric Psychiatry. - : Elsevier BV. - 1545-7214 .- 1064-7481. ; 23:9, s. 885-896
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Tidskriftsartikel (refereegranskat)abstract
- Objective To test a life-course model of cognitive reserve in dementia and examine if school grades around age 10 years, formal educational attainment, and lifetime occupational complexity affect the risk of dementia in old age. Methods 7,574 men and women from the Uppsala Birth Cohort Multigenerational Study were followed for 21 years. Information on school performance, formal education, and occupational attainment was collected prospectively from elementary school archives and population censuses. Dementia diagnosis was extracted from the two Swedish registers. Discrete-time Cox proportional hazard models were estimated. Results Dementia was diagnosed in 950 individuals (12.5%). Dementia risk was lower among individuals with higher childhood school grades (hazard ratio [HR]: 0.79; 95% confidence interval [CI]: 0.68 to 0.93) and was lower among individuals in data-complex occupations (HR: 0.77; 95% CI: 0.64 to 0.92). Professional/university education predicted lower risk of dementia in minimally adjusted models (HR: 0.74; 95% CI: 0.60 to 0.91), although the effect faded with adjustment for occupational complexity. Lowest risk was found in the group with both higher childhood school performance and high occupational complexity with data (HR: 0.61; 95% CI: 0.50 to 0.75). Importantly, high occupational complexity could not compensate for the effect of low childhood grades. In contrast, dementia risk was reduced in those with higher school grades, irrespective of occupational complexity. Conclusion Higher childhood school performance is protective of dementia risk, particularly when preserved through complex work environments in adulthood, although it will remain protective even in the absence of later-life educational or occupational stimulation.
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| 4. |
- Dekhtyar, Serhiy, et al.
(författare)
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Associations of head circumference at birth with earlylife school performance and later-life occupational prestige
- 2015
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Ingår i: Longitudinal and Life Course Studies. - : Bristol University Press. - 1757-9597. ; 6:1, s. 26-42
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Tidskriftsartikel (refereegranskat)abstract
- Head circumference at birth has been suggested as a marker of foetal brain development. New-borns with small head size have been shown to have lower intelligence scores in childhood. It is, however, unclear whether this relationship extends into adult life, and more importantly, whether adult status attainment and lifetime success is affected as a result. Furthermore it is unclear how social origin at birth attenuates the relationship between foetal brain development, childhood cognitive outcomes, and lifetime status attainment. Using the Uppsala Birth Cohort Multigenerational Study, a unique population-based database of 14,192 individuals followed from birth into advanced old age, we demonstrate that those born with small head circumference experience reductions in both early-life school performance and lifetime occupational prestige. These effects are not subject to modification by parental social class: small head size at birth is associated with lower grades and lower occupational prestige among individuals born into both advantaged and disadvantaged social classes. Employing causal mediation analysis, we also demonstrate that the link between head circumference at birth and adult occupational prestige is mainly the result of a direct effect, although a portion of this effect is also mediated by early-life school performance which also contributes to occupational attainment trajectories. These findings demonstrate the importance of early-life environments for cognitive development as well as lifetime status attainment.
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